Molecular Analysis and Treatment Options of Thymic Malignancies

NCT ID: NCT05667948

Last Updated: 2025-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2026-12-31

Brief Summary

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Thymic malignancies are the most common tumors of the anterior mediastinum, though surgery and radiation often effectively treat thymic carcinomas, a minority continue to progress and eventually lead to death. Therefore, there is an unmet need for more effective therapies for thymic malignancies. Considering the role of molecular alterations has yet to be defined in the treatment of thymoma and thymic malignancies, there is an urgent recognition that molecular alterations in the thymic malignancies are important to predict response and survival for novel targeted therapies.

In summary, identification of genetic alterations in thymic malignancies is increasingly essential to perform molecular diagnostics and individualized treatments. This project aims to create a registry of patients with thymic malignancies to further the characterization of molecular alterations and develop (novel) treatments based on the detection.

Detailed Description

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Conditions

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Thymic Epithelial Tumor Thymic Carcinoma Thymic Cancer

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Chemotherapy

different treatments based on the molecular analysis

Intervention Type DRUG

Other Intervention Names

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targeted therapy immunotherapy

Eligibility Criteria

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Inclusion Criteria

* Histologically proven diagnosis of thymic malignancies
* 18 years of age or older
* Ability to understand and the willingness to sign a written informed consent document
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Chest Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xiaomin Niu

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Xiaomin Niu

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Xiaomin Niu

Role: primary

021-22200000

Other Identifiers

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THORACIC002

Identifier Type: -

Identifier Source: org_study_id

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