Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion
NCT ID: NCT05661227
Last Updated: 2022-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
120 participants
INTERVENTIONAL
2023-01-01
2024-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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C group
Before induction of anesthesia, general anesthesia was performed after ultrasound-guided femoral nerve block
0.9% Sodium chloride
Whether apply DEX or not
DEX group
Before induction of anesthesia, general anesthesia was performed after ultrasound-guided femoral nerve block. Dexmedetomidine 0.8μg/kg was pumped intravenously for 10min 15min before induction of anesthesia, and then continued to be infused at 0.5μg/ (kg·h) until 30min before the end of surgery
Dexmedetomidine
Whether apply DEX or not
ERIPC group
Before induction of anesthesia, ultrasound-guided femoral nerve block was performed, and then general anesthesia was performed. After induction of anesthesia, orthopedic tourniquet was tied and inflated to 200 mmHg(1 mmHg=0.133 kPa) for 5 min and deflated for 5 min, and three cycles were repeated
Tourniquet(Early)
Timing of tourniquet application
LRIPC group
An orthopedic pressure tourniquet was placed on the lower extremity 24 h before surgery and inflated to 200 mmHg for 5 min and deflated for 5 min. Three cycles were repeated
Tourniquet(Late)
Timing of tourniquet application
Interventions
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Dexmedetomidine
Whether apply DEX or not
0.9% Sodium chloride
Whether apply DEX or not
Tourniquet(Early)
Timing of tourniquet application
Tourniquet(Late)
Timing of tourniquet application
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Voluntarily sign the informed consent
* ASA Grade I to III
* BMI 18-28 kg/m2
Exclusion Criteria
* Severe liver disease and kidney disease
* Temporary and permanent pacemaker implantation
* Patients with serious central nervous system diseases or serious mental disorders
* Recent history of sedation, antidepressant or opioid use
* Body mass index \>35kg/m2
* Participants in other clinical trials within 1 month prior to study enrollment.
60 Years
80 Years
ALL
No
Sponsors
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Hebei Medical University Third Hospital
OTHER
Responsible Party
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Principal Investigators
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PengChen Wang
Role: STUDY_CHAIR
Hebei Medical University Third Hospital
Locations
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The Third Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The Third Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Countries
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Central Contacts
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Facility Contacts
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Xin Liu
Role: primary
Other Identifiers
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Liuxin2022
Identifier Type: -
Identifier Source: org_study_id