Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage
NCT ID: NCT05658445
Last Updated: 2025-12-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
86 participants
OBSERVATIONAL
2023-01-01
2025-06-01
Brief Summary
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In recent years, the incidence of this disease has been on the rise, occurring in about 1%- 5% of pregnancy in women at childbearing age, and the success rate of second pregnancy in RSA females has been significantly reduced The etiology of RSA is extremely complex, including anatomical factors, genetic factors, endocrine factors, infectious and immune factors, and pre-thrombosis etiology.
However, the cause of the disease is unclear in half of patients and known as unexplained recurrent spontaneous abortion (URSA)
Detailed Description
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* Additionally, microRNA (miR)-410-5p has been discovered to serve as oncogenes and tumor suppressors altering cell functions in numerous ways including proliferation, apoptosis, biochemistry metabolism, and inflammatory responses in different human malignancies, such as liver cancer, pancreatic cancer, colon cancer, and non-small cell lung cancer. Recent studies showed that miR-410-5p may be involved in the non-cancerous disorder processes such as RSA . Overexpression of miR-410-5p in trophoblast cells inhibited the polarization of M2 macrophages, while knockdown of miR-410-5p was beneficial to recruitment of trophoblast cell and promoted the polarization of M2 macrophages. Furthermore, MicroRNA (miR)-410-5p was discovered to bind with 3'-UTR of ITGA6 .
* The adhesion molecule integrin alpha-6 (ITGA6, CD49f), a member of the integrin family, is overexpressed in many cancers and enhances cell movement and signal output .
* Down-regulation of ITGA6 changed the biological function of trophoblast cells, inhibited cell proliferation, invasion and migration, and induced apoptosis. ITGA6 may affect the biological functions of trophoblast cells by regulating PI3K/AKT and MAPK signaling pathways. MAPK signaling promote apoptosis through inducing releasing of cytochrome c, which in turn induces further caspase activation (caspase-9 and the effector caspases-3, -6, and -7) .
* Baculoviral IAP Repeat Containing 7(BIRC7) encodes the protein Livin which is a member of the inhibitor of apoptosis protein (IAP) family. Livin consists of a single baculoviral IAP repeat domain (BIR) and a RING domian at the C-terminus. The protein inhibits apoptosis by inhibiting proteolytic activation of capsases.
* Currently, the interaction of BIRC7 and NK cells in endometrium/decidual remains unknown. BIRC7 in decidua cell may possess the ability to prevent NK cells from killing embryonic and extraembryonic cells, decreased level of BIRC7 and increased number of NK cells in the RM group attribute to the occurrence of miscarriage
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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cases
Female with recurrent unexplained abortion
evacuation
after complete evacuation of uterus follow abortion
control
female with normal labour
evacuation
after complete evacuation of uterus follow abortion
Interventions
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evacuation
after complete evacuation of uterus follow abortion
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. Female with explained causes of miscarriage
3. Female with cancer
4. Female with chronic illness.
5. Pregnant women above 30
20 Years
30 Years
FEMALE
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Nesma Gamal
faculty of medicine Assuit university
Locations
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Medical Bochemistry Department
Asyut, Assuit, Egypt
Countries
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Other Identifiers
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As
Identifier Type: -
Identifier Source: org_study_id