Body Weight Adjusted Clopidogrel Treatment in Patients With CORonary Artery Disease

NCT ID: NCT05657041

Last Updated: 2023-06-02

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2/PHASE3
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-04-26
• Study Completion Date: 2024-11-01

Brief Summary

Extreme body weights (BW) or body mass index (BMI) affect the pharmacokinetics of antithrombotic drugs and consequently may affect cardiovascular risk during treatment. The goal of this clinical trial is to establish if clopidogrel treatment can be optimized in patients with a low or high BW compared to patients with a normal BW by adjusting the dosage of clopidogrel and evaluating platelet reactivity.

Participants are stratified into three groups based on their BW (Low BW: BW <60kg; normal BW: 60-100kg; High BW: >100 kg)

Clopidogrel dosage will then be adjusted to the BW, as follows:

• Low BW: >10 days clopidogrel 50mg 1dd1, followed by >10 days clopidogrel 25mg 1dd1.
• Normal BW: Clopidogrel 75mg 1dd1.
• High BW: >10 days clopidogrel 150mg 1dd1 followed by >10 days prasugrel 10mg 1dd1.

The primary endpoint of the study is P2Y12 Reaction Units (PRU) and platelet inhibition measured using the VerifyNow measured before starting new treatment regimen (at the end of 10 days of treatment).

Detailed Description

Patients with a high BMI/BW have a higher cardiovascular risk and patients with a low BMI/BW seem to have a higher bleeding risk. A high BMI/BW affects the efficacy of clopidogrel. It is not yet known if this clopidogrel efficacy is altered in patients with a low BMI/BW and whether BW-adjusted treatment can optimise this efficacy. We hypothesize that a personalised treatment will eventually lead to a more optimal effect of clopidogrel, optimizing the balance between bleeding and thrombotic risk. This could benefit therapy compliance.

Primary Objective:

To determine if clopidogrel treatment can be optimized in patients with a low or high BW compared to patients with a normal BW by adjusting the dosage of clopidogrel and evaluating platelet reactivity measured using the VerifyNow.

Secondary Objective(s):

To determine if the CYP2C19 genotype has additional effect on the platelet reactivity in the different treatment groups.

This is a non-randomized single centre, prospective, experimental study in patients with CCS treated with clopidogrel 75mg (and aspirin). This study is designed to be pragmatic and is intended to be hypothesis generating. Patients have to be treated with clopidogrel for at least one month without the occurrence of a major bleeding event, an ischemic event (stroke, myocardial infarction, or coronary revascularization) and have to be free of angina complaints.

Participants are stratified into three groups based on their BW (Low BW: BW <60kg; normal BW: 60-100kg; High BW: >100 kg)

Clopidogrel dosage will then be adjusted to the BW, as follows:

• Low BW: >10 days clopidogrel 50mg 1dd1, followed by >10 days clopidogrel 25mg 1dd1.
• Normal BW: Clopidogrel 75mg 1dd1.
• High BW: >10 days clopidogrel 150mg 1dd1 followed by >10 days prasugrel 10mg 1dd1.

Conditions

Coronary Artery Disease; Platelet Reactivity

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Group 1: body weight <60kg

Treatment with clopidogrel 50mg once daily for a minimum of 10 days (max. 14 days), followed by a minimum of 10 days treatment with clopidogrel 25mg once daily (max 14 days).

Group Type: EXPERIMENTAL

Clopidogrel

Intervention Type: DRUG

Body weight adjusted clopidogrel dosing

Group 2: body weight 60-100kg

Treatment with clopidogrel 75mg once daily

Group Type: NO_INTERVENTION

No interventions assigned to this group

Group 3: body weight >100kg

Treatment with clopidogrel 150mg once daily for a minimum of 10 days (max. 14 days), followed by a minimum of 10 days treatment with prasugrel 10mg once daily (max 14 days).

Group Type: EXPERIMENTAL

Clopidogrel

Intervention Type: DRUG

Body weight adjusted clopidogrel dosing

Interventions

Clopidogrel

Body weight adjusted clopidogrel dosing

Intervention Type: DRUG

Other Intervention Names

Prasugrel; Body weight adjusted

Eligibility Criteria

Inclusion Criteria

• Patients, male or female, ≥18 years of age
• Patients treated for CCS with clopidogrel 75mg QD (aspirin 100mg QD).
• Patients must be treated with clopidogrel 75mg for at least one month
• Patients must give consent by means of a signed informed consent

Exclusion Criteria

• Contra-indication for aspirin
• Contra-indication for clopidogrel or prasugrel
• Occurrence of an ischemic event after PCI or ACS (stroke, myocardial infarction, or coronary revascularization)
• Presence of unstable angina complaints.
• Presence of two CYP2C19 Loss-of-function (LOF) alleles (*2 or *3)
• Scheduled for cardiac valve surgery
• Indication for chronic oral anticoagulants
• Expected life span of less than one year
• Pregnancy
• Suboptimal stent placement as determined by the cardiologist.
• Patients at increased risk of bleeding with two of the following characteristics: liver cirrhosis with portal hypertension, enhanced bleeding tendency, active malignancy in the past 12 months, thrombocytopenia, major surgery in the past month, spontaneous intracerebral haemorrhage, traumatic intracerebral haemorrhage in the past 12 months, major bleeding requiring hospitalisation or blood transfusion in the past month, ischaemic CVA in the past 5 months.
• Known with established stent thrombosis

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

St. Antonius hospital Onderzoeksfonds

UNKNOWN

Sponsor Role: collaborator

Ace pharmaceuticals

UNKNOWN

Sponsor Role: collaborator

Allgen pharmaceuticals

UNKNOWN

Sponsor Role: collaborator

St. Antonius Hospital

OTHER

Sponsor Role: lead

Responsible Party

Jurriën M. ten Berg, MD, PhD

Prof. dr.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

StAntoniusH

Nieuwegein, Utrecht, Netherlands

Site Status: NOT_YET_RECRUITING

St. Antonius Hospital

Nieuwegein, , Netherlands

Site Status: RECRUITING

Countries

Netherlands

Facility Contacts

Wout van den Broek, MD

Role: primary

w.van.den.broek2@antoniusziekenhuis.nl

088 320 13 37

Jurrien ten berg

Role: primary

j.ten.berg@antoniusziekenhuis.nl

088 320 09 00

Other Identifiers

NL81095.100.22

Identifier Type: -

Identifier Source: org_study_id