Comparison of Pericapsular Nerve Group Block and Quadratus Lumborum Block

NCT ID: NCT05654519

Last Updated: 2024-12-20

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-01-01
• Study Completion Date: 2023-04-21

Brief Summary

Adequate pain management following total hip arthroplasty (THA) is a key component for patient satisfaction and early ambulation. However, due to the complexity of the innervation of the hip joint, the most appropriate anaesthetic and analgesic technique for THA remains unclear. A femoral nerve block is commonly performed and well established but is associated with motor weakness. Recently, the pericapsular nerve group (PENG) block has been introduced as an effective choice which targets the articular branches of the hip. The quadratus lumborum block (QLB) is a relatively new regional block that has been reported to provide effective analgesia for THA.

The main objective of this study is to compare the effectiveness of the ultrasound-guided PENG block technique compared to QLB block in terms of efficacy of pain control and the safety profile after total hip arthroplasty under spinal anesthesia.

Detailed Description

The patients will be randomly classified into two equal groups (40 patients each). Group allocation will be done by computer generated random numbers and closed opaque sealed envelopes. The study will be designed to be double blind as all patients and outcomes assessor will be blinded to group assignment.

Patients will be randomized to one of three equal groups:

Group I (n= 40 patients): Patients in this group will receive an ipsilateral single shot of QLB (30 ml of plain bupivacaine 0.25%) after surgery using ultrasonographic guidance.

Group II(n= 40 patients): patients in this group will receive an ipsilateral single-shot of PENG block (25 ml of plain bupivacaine 0.25%) and LFCN block (5 ml of plain bupivacaine 0.25%) after surgery using ultrasonographic guidance.

Conditions

Total Hip Surgery; Pericapsular Nerve; Quadratus Lumborum

Keywords

Total Hip Surgery; PENG block; QLB

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Group QL Block

A convex transducer will be placed in the transverse plane on the flank cranial to the iliac crest to visualise the transverse process of the 4th lumbar vertebra, erector spina, quadratus lumborum and psoas muscles as a 'Shamrock sign'. The needle will inserted in to the fascial plane between the quadratus lumborum and psoas muscles and 30 ml bupivacaine 0.25% will be administered.

Group Type: ACTIVE_COMPARATOR

PENG/LFCN and QL Blocks

Intervention Type: DRUG

Bupivacaine 0.25% injection

Group PENG+LFCN Block

A linear probe will be placed on the anterior inferior iliac crest in the transverse plane while the patient is in the supine position. After rotating 45 degrees, the pubic ramus, femoral artery and psoas muscle will be visualized. Puncture will be performed in a lateromedial direction until the needle tip reached the plane between the iliopsoas tendon and the iliopubic eminence After a negative aspiration test, 25 ml bupivacaine 0.25% will be injected.

Then, the lateral femoral cutaneous nerve (LFCN) block was performed using linear US probe (10-18 MHz).The LFCN will be localized, infero-medially to the antero-superior iliac spine, laterally to the sartorius muscle and 5 ml of bupivacaine 0.25% will be carefully injected.

Group Type: ACTIVE_COMPARATOR

PENG/LFCN and QL Blocks

Intervention Type: DRUG

Bupivacaine 0.25% injection

Interventions

PENG/LFCN and QL Blocks

Bupivacaine 0.25% injection

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

Physical status according to American Society of Anesthesiologists (ASA ) I-III

Exclusion Criteria

• Younger than 40 years old and older than 85
• Patients undergoing general anesthesia
• Allergy or intolerance to one of the study medications
• Infection of the skin at the site of the needle puncture,
• Patients who do not accept the procedure
• History of bleeding diathesis
• ASA IV,
• Chronic gabapentin/pregabalin,opioid use
• Hepatic or renal insufficiency
• Previous operation on the same hip
• BMI >40

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Konya Necmettin Erbakan Üniversitesi

OTHER

Sponsor Role: lead

Responsible Party

Alper Kilicaslan

Clinical Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Alper KILICASLAN

Konya, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

References

Hussain N, Brull R, Speer J, Hu LQ, Sawyer T, McCartney CJL, Abdallah FW. Analgesic benefits of the quadratus lumborum block in total hip arthroplasty: a systematic review and meta-analysis. Anaesthesia. 2022 Oct;77(10):1152-1162. doi: 10.1111/anae.15823. Epub 2022 Aug 10.

Reference Type: BACKGROUND

PMID: 35947882 (View on PubMed)

Giron-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847.

Reference Type: BACKGROUND

PMID: 30063657 (View on PubMed)

Other Identifiers

2021-541

Identifier Type: -

Identifier Source: org_study_id