Clinical Study of Tumor Treating Fields Combined with Gemcitabine and Albumin-bound Paclitaxel in the First-line Treatment of Locally Advanced Pancreatic Cancer

NCT ID: NCT05653453

Last Updated: 2025-03-24

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 512 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-20
• Study Completion Date: 2027-09-28

Brief Summary

The Objectives of this clinical trial is to evaluate the efficacy and safety of tumor treating fields combined with gemcitabine and albumin bound paclitaxel in the treatment of locally advanced pancreatic cancer.

Conditions

Locally Advanced Pancreatic Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Tumor treating fields combined with Gemcitabine hydrochloride and albumin binding paclitaxel

Device: Tumor treating fields Subjects will use tumor treating fields each day

Drug: Gemcitabine hydrochloride and albumin binding paclitaxel 28 days is a cycle. On the 1st, 8th and 15th days of each cycle, 125 mg/m2 albumin binding paclitaxel will be administered intravenously，1000 mg/m2 gemcitabine hydrochloride will be administered immediately after the infusion of albumin binding paclitaxel.

Group Type: EXPERIMENTAL

Tumor treating fields combined with Gemcitabine hydrochloride and albumin binding paclitaxel

Intervention Type: DEVICE

Device: Tumor treating fields Subjects will use tumor treating fields until disease progression or for a maximum of 30 months.

Drug: Gemcitabine hydrochloride and albumin binding paclitaxel Subjects will receive Gemcitabine hydrochloride and albumin binding paclitaxel until disease progression or for a maximum of 30 months.

Gemcitabine hydrochloride and albumin binding paclitaxel

Intervention Type: DRUG

Drug: Gemcitabine hydrochloride and albumin binding paclitaxel Subjects will receive Gemcitabine hydrochloride and albumin binding paclitaxel until disease progression or for a maximum of 30 months.

Gemcitabine hydrochloride and albumin binding paclitaxel

Drug: Gemcitabine hydrochloride and albumin binding paclitaxel 28 days is a cycle. On the 1st, 8th and 15th days of each cycle, 125 mg/m2 albumin binding paclitaxel will be administered intravenously，1000 mg/m2 gemcitabine hydrochloride will be administered immediately after the infusion of albumin binding paclitaxel.

Group Type: ACTIVE_COMPARATOR

Gemcitabine hydrochloride and albumin binding paclitaxel

Intervention Type: DRUG

Drug: Gemcitabine hydrochloride and albumin binding paclitaxel Subjects will receive Gemcitabine hydrochloride and albumin binding paclitaxel until disease progression or for a maximum of 30 months.

Interventions

Tumor treating fields combined with Gemcitabine hydrochloride and albumin binding paclitaxel

Device: Tumor treating fields Subjects will use tumor treating fields until disease progression or for a maximum of 30 months.

Drug: Gemcitabine hydrochloride and albumin binding paclitaxel Subjects will receive Gemcitabine hydrochloride and albumin binding paclitaxel until disease progression or for a maximum of 30 months.

Intervention Type: DEVICE

Gemcitabine hydrochloride and albumin binding paclitaxel

Drug: Gemcitabine hydrochloride and albumin binding paclitaxel Subjects will receive Gemcitabine hydrochloride and albumin binding paclitaxel until disease progression or for a maximum of 30 months.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Subjects aged between 18 and 75 (including 18 and 75) of both genders;

2. Expected survival time ≥3 months;

3. Pancreatic adenocarcinoma confirmed by histology/cytology;

4. Locally advanced lesions meeting any of the following criteria without distant metastasis: ① Pancreatic head and neck tumors: a. The tumor invaded the Superior Mesenteric Artery (SMA) more than 180°; b. The tumor invaded the celiac trunk more than 180°; c. Unresectable reconstruction of superior mesenteric vein or portal vein due to tumor invasion or embolism (tumor thrombus or thrombus); d. The tumor extensively invaded the distal jejunal drainage branch of the superior mesenteric vein. ② Pancreatic body/tail tumor: a. The tumor invaded the superior mesenteric artery or celiac trunk more than 180°; b. Celiac trunk and abdominal aorta involvement; c. The superior mesenteric vein or portal vein cannot be resected and reconstructed due to tumor invasion or embolism (tumor thrombus or thrombus).

5. At least one measurable lesion according to revised RECIST version 1.1;

6. ECOG score 0-1;

7. Be able to receive gemcitabine for injection and paclitaxel for injection (albumin-bound) combined therapy according to medical advice;

8. Able to operate tumor treating fields independently or with the help of nursing staff;

9. AE should be restored to normal or CTCAE1 grade after previous treatment;

10. The serum pregnancy test results of female subjects of reproductive age were negative. Female subjects of reproductive age agree to use effective contraception (e.g. hormonal or barrier methods or abstinence) during the study period and for 6 months after the last dose of chemotherapy drugs;

11. Male subjects agree to use effective birth control (such as barrier method or abstinence) and not to donate sperm during the study and within 3 months after the last chemotherapy drug administration;

12. Voluntarily sign the informed consent.

Exclusion Criteria

1. The subjects has previously received first-line treatment for pancreatic adenocarcinoma;

2. Subjects with contraindications to treatment with gemcitabine for injection and/or paclitaxel for injection (albumin-bound) or known severe allergies to gemcitabine for injection and/or paclitaxel for injection (albumin-bound);

3. Patients had cancer requiring other antitumor therapy within 2 years before enrollment, excluding treated stage I prostate cancer, cervical cancer in situ, breast cancer in situ, and non-melanoma skin cancer;

4. Abnormal bone marrow, heart, liver and kidney function: a. Neutrophil count < 1.5 × 10^9/L, platelet count < 100 × 10^9/L, hemoglobin < 90g/L; The use of blood transfusion, platelet transfusion and erythropoietin was prohibited within 14 days before C1D1, and the use of Leukocytotropic drug such as G-CSF, fegrasstim, pefegrasstim, etc., was prohibited within 7 days before C1D1.b. Total bilirubin > 1.5× Upper Limit of Normal (ULN); Subjects with a total bilirubin > 2×ULN that is elevated due to pancreatic cancer compression of the bile duct but has been fitted with a bile duct stent for drainage can be enrolled. AST and/or ALT> 2.5×ULN; the use of drugs that improve liver function, such as reducing transaminase was prohibited within 7 days before C1D1. c. Serum creatinine > 1.5×ULN; d. A history of severe cardiovascular disease, including but not limited to second or third degree heart block; Severe ischemic heart disease; New York Heart Association (NYHA) class II or higher congestive heart failure (mild physical activity limitation; Comfortable at rest, but normal activities can cause fatigue, palpitations, or difficulty breathing);

5. Subjects who were required to receive systemic corticosteroids (doses equivalent to > 10 mg prednisone/day) or other immunosuppressive agents within 14 days before enrollment or during the study period. Subjects were eligible for enrollment if: a. The use of topical or inhaled glucocorticoids is permitted; b. Allow short-term (≤7 days) use of glucocorticoids for the prevention or treatment of non-autoimmune allergic diseases;

6. Those who had severe infection before the first dose were judged ineligible for the study by the investigator;

7. History of human immunodeficiency virus (HIV) infection (known HIV1/2 antibody positive);

8. The presence of active hepatitis B, active hepatitis C, or other active infections that may affect the patient's treatment as determined by the investigator;

9. Subjects with a clear history of neurological or psychiatric disorders, such as epilepsy, dementia, or substance abuse (including alcohol) within the last year, and possibly affecting compliance;

10. Infected, ulcerated or unhealed wounds exist on the skin where the tumor treating fields is applied;

11. Having an implantable electronic medical device, such as a pacemaker;

12. Metal medical instruments are implanted in the chest and abdomen such as bone nails;

13. Known allergies to medical adhesives or hydrogels;

14. Pregnant or breastfeeding;

15. Subjects participated in clinical trials of other drugs within 3 months before enrollment, or participated in clinical trials of other devices within 1 month before enrollment;

16. Subjects with poor compliance or other factors as judged by the investigator.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jiangsu Healthy Life Innovation Medical Technology Co., Ltd

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, China

Site Status: RECRUITING

Cancer Hospital of Shandong First Medical University

Jinan, Shandong, China

Site Status: RECRUITING

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Fudan University Affiliated Huashan Hospital

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Huashan Hospital Affiliated to Fudan University

Shanghai, Shanghai Municipality, China

Site Status: NOT_YET_RECRUITING

Countries

China

Central Contacts

Fu

Role: CONTACT

Surgeonfu@163.com

021-52889999

Facility Contacts

Fu

Role: primary

Surgeonfu@163.com

021-52889999

Other Identifiers

P100-LAPC1

Identifier Type: -

Identifier Source: org_study_id