Quinolone Resistance Profiles and Mechanisms of Staphylococcus Aureus and Escherichia Coli From Humans, Chicken and Catfish Farms in Indonesia
NCT ID: NCT05652556
Last Updated: 2022-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
480 participants
OBSERVATIONAL
2022-12-09
2023-03-31
Brief Summary
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The main questions it aims to answer are:
* Obtain the quinolone resistance profiles and mechanisms of S. aureus and E. coli in human health, animal health and aquaculture health sector in Blitar, Indonesia.
* Obtain the association of AMR and AMU data within and between the human health, animal health and aquaculture health sector in Blitar, for quinolones.
Detailed Description
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The quinolones are broad-spectrum antibiotics that are probably one of the most widely used drugs for the treatment of several community and hospital-acquired infections in the human health sector. It is also used in aquaculture and agricultural fields, for instance in chicken farms. The use of quinolones and other "Watch antibiotics" in many countries monitored by the World Health Organization since 2016 varies a lot and ranges from less than 20% to more than 50%.
It is well documented that several pathogenic bacteria have developed resistance as a consequence of exposure to the antimicrobials. Resistant bacteria can spread to humans directly from the food chain, and indirectly from the environmental pollution of farm effluents. This study will reveal quinolone resistance profiles and mechanisms in S. aureus and E. coli in the human, animal and aquaculture sector in Blitar, Indonesia.
Population The research populations are residents (farmers and non-farmers) in Kabupaten Blitar.
Sample
Layer farm:
Samples will be taken in layer farms in the Blitar region. The type of sample will be bootswab samples as published before; 25 E. coli isolates/farm will be collected. A total of 30 farms will be included.
Aquaculture sample:
Aquaculture samples will be taken from catfish ponds in several regions in Kabupaten Blitar. One sample of water or mud of one pond will be taken (the pond closest to the entrance). From this sample, 5 E. coli will be isolated.
Human sample:
Human samples will be taken from people on layer and aquaculture farms (farmers, farmworkers and family members of farmers), and non-farmer residents of several regions in Kabupaten Blitar. Nasal (S. aureus) and rectal (E. coli) samples will be taken after informed consent. AMU data will be collected via questionnaires.
Conditions
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Keywords
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Study Design
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ECOLOGIC_OR_COMMUNITY
CROSS_SECTIONAL
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Dr. Soetomo General Hospital
OTHER_GOV
Balai Besar Laboratorium Kesehatan (BBLK) Surabaya
UNKNOWN
National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
OTHER
Directorate of Veterinary Public Health, Ministry of Agriculture, Indonesia
UNKNOWN
Directorate of Animal Health, Ministry of Agriculture, Indonesia
UNKNOWN
Ministry of Marine and Fisheries, Indonesia
UNKNOWN
Utrecht University
OTHER
Radboud University Medical Center
OTHER
National Institute for Public Health and the Environment (RIVM)
OTHER_GOV
Erasmus Medical Center
OTHER
Responsible Party
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Juliëtte Severin
Associate professor, Medical coordinator Unit infection prevention
Principal Investigators
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Juliëtte A. Severin, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Erasmus Medical Center
Central Contacts
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Other Identifiers
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QUINDO
Identifier Type: -
Identifier Source: org_study_id