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Features of Regional Perfusion of Lung Consolidation

NCT ID: NCT05647967

Last Updated: 2022-12-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2024-01-31

Brief Summary

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The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.

Detailed Description

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Lung consolidation is one of the most causes of hypoxia in intensive care unit(ICU) settings. A quantitative measurement of consolidation would be extremely benefit for the clinical management in hypoxemia, both as an index of severity and to predict outcomes.In order to quantify the lung consolidation and its effect on clinical outcomes, a simple and quantitative scoring system of the size and perfusion of lung consolidation was proposed by lung ultrasound. Subjects with respiratory failure and lung consolidation proved by chest imaging underwent lung ultrasound examination. The size of consolidation and the richness of blood flow was computed upon lung ultrasound. The sensitivity, specificity and accuracy of the scoring system were calculated and compared to evaluate the diagnostic efficacy.

Conditions

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Lung Injury, Acute Ultrasound Therapy; Complications

Keywords

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lung consolidation, respiratory failure, perfusion

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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the consolidation perfusion/the consolidation size

Patients with respiratory failure and lung consolidation proved by chest imaging underwent lung ultrasound to evaluate the regional perfusion and the size of consolidation.

Ultrasound

Intervention Type DIAGNOSTIC_TEST

Each patient underwent ultrasound after admission of ICU.

Interventions

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Ultrasound

Each patient underwent ultrasound after admission of ICU.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Admission to ICU( 18yr\<age\<90yr);
2. Patients presented with acute respiratory failure;
3. Pulmonary consolidation by chest imaging (lung ultrasound, X ray or CT scan).

Exclusion Criteria

1. Hemodynamic instability (i.e., severe hypotension with systolic arterial pressure\<60mmHg despite fluid expansion and vasoactive support; systolic arterial pressure\>180mmHg; uncontrolled cardiac arrhythmias);
2. Severe thoracic trauma;
3. Coronavirus disease 2019;
4. Pulmonary artery hypertension and pregnancy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Huaiwu He, MD

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College Hospital

Locations

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Peking union medical college hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Na Wang, MD

Role: CONTACT

Phone: 17810258960

Email: [email protected]

Huaiwu He, MD

Role: CONTACT

Phone: 010-69152300

Email: [email protected]

Facility Contacts

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Na Wang, MD

Role: primary

References

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Wang N, Chi Y, Wang Q, Long Y, Liu D, Zhao Z, He H. Relationship between lung consolidation size measured by ultrasound and outcome in ICU patients with respiratory failure. BMC Pulm Med. 2025 Feb 26;25(1):91. doi: 10.1186/s12890-025-03564-6.

Reference Type DERIVED
PMID: 40011857 (View on PubMed)

Other Identifiers

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I-22PJ140

Identifier Type: -

Identifier Source: org_study_id