A Multiple Dose Trial of Emraclidine in Elderly Participants and in Participants With Dementia Due to Alzheimer's Disease

NCT ID: NCT05644977

Last Updated: 2025-05-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-02
• Study Completion Date: 2025-04-14

Brief Summary

The primary purpose of the study is to evaluate the safety and tolerability of emraclidine administered orally to healthy elderly participants in Part A (multiple ascending doses) and participants with dementia due to Alzheimer's disease (AD) in Part B.

Conditions

Healthy Participants; Alzheimer's Disease Dementia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Part A: Cohort 1: Emraclidine Dose 1

Participants will receive emraclidine dose 1 or emraclidine-matching placebo tablets, orally, once daily (QD) up to Day 14.

Group Type: EXPERIMENTAL

Emraclidine

Intervention Type: DRUG

Oral tablets

Placebo

Intervention Type: DRUG

Oral tablets

Part A: Cohort 2: Emraclidine Dose 2

Participants will receive emraclidine dose 2 or emraclidine-matching placebo tablets, orally, QD up to Day 14.

Group Type: EXPERIMENTAL

Emraclidine

Intervention Type: DRUG

Oral tablets

Placebo

Intervention Type: DRUG

Oral tablets

Part A: Cohort 3: Emraclidine Dose 3

Participants will receive emraclidine dose 3 or emraclidine-matching placebo tablets, orally, QD up to Day 14.

Group Type: EXPERIMENTAL

Emraclidine

Intervention Type: DRUG

Oral tablets

Placebo

Intervention Type: DRUG

Oral tablets

Part A: Cohort 4: Emraclidine Dose 4

Participants will receive emraclidine dose 4 or emraclidine-matching placebo tablets, orally, QD up to Day 14.

Group Type: EXPERIMENTAL

Emraclidine

Intervention Type: DRUG

Oral tablets

Placebo

Intervention Type: DRUG

Oral tablets

Part A: Cohort 5: Emraclidine Dose 5

Participants will receive emraclidine dose 5 or emraclidine-matching placebo tablets, orally, QD up to Day 14.

Group Type: EXPERIMENTAL

Emraclidine

Intervention Type: DRUG

Oral tablets

Placebo

Intervention Type: DRUG

Oral tablets

Part B: Cohort 6: Emraclidine Dose 6

Participants with dementia due to AD will receive emraclidine dose 6 or emraclidine-matching placebo tablets, orally, QD up to Day 28.

Group Type: EXPERIMENTAL

Emraclidine

Intervention Type: DRUG

Oral tablets

Placebo

Intervention Type: DRUG

Oral tablets

Interventions

Emraclidine

Oral tablets

Intervention Type: DRUG

Placebo

Oral tablets

Intervention Type: DRUG

Other Intervention Names

CVL-231; PF-06852231

Eligibility Criteria

Inclusion Criteria

Cohorts 1 to 5 (Part A)

1. Male participants and female participants of nonchildbearing potential, ages 65 to 85 years, inclusive.

2. Healthy as determined by medical evaluation, including medical and psychiatric history, physical and neurological examinations, ECG, vital sign measurements, and laboratory test results, as evaluated by the investigator.

3. Body mass index of 17.5 to 32.0 kilograms per square meter (kg/m^2), inclusive, and total body weight >45 kg (100 pounds [lb]) at Screening.

4. Female participants will be of nonchildbearing potential, defined as follows:

• Achieved postmenopausal status, defined as follows: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause, and confirmed with a serum follicle-stimulating hormone level >40 international units per milliliter (IU/mL).

5. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in the full protocol.

Cohort 6 (Part B)

1. Male participants and female participants of nonchildbearing potential, ages 55 to 90 years, inclusive.

2. Have a clinical diagnosis of possible or probable Alzheimer's disease dementia according to the 2011 National Institute on Aging - Alzheimer's Association (NIA-AA) clinical criteria at the Screening Visit; diagnosis must be stable for at least 6 months prior to signing the ICF.

3. Have a Mini-Mental State Examination (MMSE) score of 8 through 26, inclusive, at the Screening Visit.

4. Have prior neuroimaging evidence (Computed Tomography [CT] or Magnetic resonance imaging [MRI] completed within the 3 years prior to signing the ICF) collected during or subsequent to the onset of dementia symptoms to rule out other central nervous system disorders that could account for the dementia syndrome.

5. Currently receiving oral symptomatic treatment for dementia (i.e., cholinesterase inhibitor and/or memantine), must have been on a stable regimen for at least 6 weeks prior to signing ICF and be willing to maintain a stable dose for the duration of the trial.

6. Body mass index of 17.5 to 40.0 kg/m2, inclusive, and total body weight >45 kg (100 lb) at Screening.

Exclusion Criteria

All Cohorts

1. "Yes" responses for any of the following items on the C-SSRS (within the past 6 months):

• Suicidal Ideation Item 4 (Active Suicidal Ideation with Some Intent to Act, without Specific Plan)
• Suicidal Ideation Item 5 (Active Suicidal Ideation with Specific Plan and Intent) "Yes" responses for any of the following items on the C-SSRS (within past 2 years):
• Any of the Suicidal Behavior items (Actual Attempt, Interrupted Attempt, Aborted Attempt, Preparatory Acts or Behavior). Serious risk of suicide in the opinion of the investigator is also exclusionary.

2. Diagnosis of moderate to severe substance or alcohol-use disorder (excluding nicotine or caffeine) as per Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria within 12 months prior to signing the ICF.

3. Positive drug screen or a positive test for alcohol at Screening or Baseline Visits.

4. Any of the following clinical laboratory test results at the Screening Visit (as assessed by the central laboratory) and at Check-in (Day -1; as assessed by the local laboratory), and confirmed by a single repeat measurement, if deemed necessary:

• aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≥2.0 × upper limit normal (ULN)
• Total bilirubin >1.5 × ULN. If Gilbert's syndrome is suspected, total bilirubin >1.5 × ULN is acceptable if the conjugated or direct bilirubin fraction is <20% of total bilirubin.

Cohorts 1 to 5 (Part A)

1. Current or past history of significant pulmonary, gastrointestinal, renal, hepatic, metabolic, genitourinary, endocrine (including diabetes mellitus), malignancy (except for basal cell carcinoma of the skin and cervical carcinoma in situ, at the discretion of the investigator), hematological, immunological, neurological, or psychiatric disease that, in the opinion of the investigator or medical monitor, could compromise either participant safety or the results of the trial.

2. Current or past history of significant cardiovascular disease.

3. Estimated glomerular filtration rate <60 milliliters per minute (mL/min)/1.73 m^2, as calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI 2021) equation at the Screening Visit or Check-in (Day -1).

Cohort 6 (Part B)

1. Has either of the following:

• History of major depressive episode with psychotic features during the 12 months prior to signing the ICF
• History of a diagnosis of bipolar disorder, schizophrenia, or schizoaffective disorder

2. Has evidence of a clinically relevant neurological disorder other than possible or probable Alzheimer's disease such as, but not limited to, the following:

• History of ischemic stroke within 12 months prior to signing the ICF or any evidence of hemorrhagic stroke
• History of cerebral amyloid angiopathy, epilepsy, or central nervous system neoplasm

3. Estimated glomerular filtration rate <60 mL/min/1.73 m2, as calculated using the CKD-EPI 2021 equation the Screening Visit.

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

AbbVie

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

Cypress, California

Cypress, California, United States

San Diego, California

San Diego, California, United States

Hialeah, Florida

Hialeah, Florida, United States

Decatur, Georgia

Decatur, Georgia, United States

Honolulu, Hawaii

Honolulu, Hawaii, United States

Overland Park, Kansas

Overland Park, Kansas, United States

Farmington Hills, Michigan

Farmington Hills, Michigan, United States

Marlton, New Jersey

Marlton, New Jersey, United States

Princeton, New Jersey

Princeton, New Jersey, United States

Staten Island, New York

Staten Island, New York, United States

North Canton, Ohio

North Canton, Ohio, United States

Countries

United States

Other Identifiers

CVL-231-1006

Identifier Type: -

Identifier Source: org_study_id