Antenatal Corticosteroid Therapy: Which Impact on Birth Parameters?
NCT ID: NCT05640596
Last Updated: 2022-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
363 participants
OBSERVATIONAL
2014-01-01
2022-11-25
Brief Summary
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Nevertheless, few studies have been conducted to investigate the impact of this antenatal corticosteroid therapy on full-term newborns (\> 36 weeks' gestation).
The aim of this study is to compare the birth parameters of full-term newborns exposed or not to antenatal corticosteroid therapy.
Detailed Description
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One hundred and twenty-one of them were exposed during pregnancy to antenatal corticosteroids therapy and constitute the exposed arm, whereas 242 were not and constitute the non-exposed arm.
Data were collected retrospectively regarding history of pregnancy, birth parameters and neonatal adaptation.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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exposed group (121 patients)
Extrated from the population of full-term newborns (\> 36 weeks of amenorrhea + 6 days) between 2014 and 2020 at the Regional Maternity Hospital of Nancy who received at least one course of betamethasone before 34 weeks of amenorrhea for a threat of preterm delivery.
Exposure to an antenatal corticosteroid therapy was defined as the administration of at least one course of betamethasone (i.e. two doses of 12 mg, 24 hours apart). in intramuscular, before 34 weeks of amenorrhea, for a threat of premature delivery.
Betamethasone
nonexposed group (242 patients)
came from the population of full-term newborns (\> 36 weeks of amenorrhea + 6 days) between 2014 and 2020 at the Regional Maternity Hospital of Nancy who who had not been exposed to antenatal steroid therapy. Two controls were selected for a case, appaired on the month and year of birth and on the sex of the case patient.
No interventions assigned to this group
Interventions
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Betamethasone
Eligibility Criteria
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Inclusion Criteria
* only full-term newborns
Exclusion Criteria
12 Months
ALL
No
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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RENARD Emeline
Doctor
References
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Best C, Hascoet JM, Jeanbert E, Morel O, Baumann C, Renard E. Impact of corticosteroid exposure on preterm labor in neonates eventually born at term. J Perinatol. 2024 Feb;44(2):195-202. doi: 10.1038/s41372-023-01831-0. Epub 2023 Dec 1.
Other Identifiers
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2021PI166
Identifier Type: -
Identifier Source: org_study_id