Virtual Reality Applied to the Evaluation and Rehabilitation of Locomotion - Study of Tolerance in the Lower Limb Amputee

NCT ID: NCT05635799

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-06

Study Completion Date

2025-11-26

Brief Summary

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The adaptability of the locomotor activity allows to face all the modifications of the immediate environment met in the daily activities. These situations become complex to apprehend for a person with a locomotor disability such as patients fitted with a lower limb amputation device. Thus, these adaptation capacities are essential to take into account in the rehabilitation process to maximize autonomy and reduce the risk of falls. For this purpose, the Quantitative Gait Analysis (QGA) allows to measure the impact of these constraining situations on the organization of gait patterns. However, this evaluation could be considerably optimized in current practice with the contribution of Virtual Reality (VR), by its immersive power which brings it closer to real life conditions (walking in a straight line, going up/down steps, taking into account visual and sound constraints, etc.). Eventually, this immersive approach by various VR environments could allow to improve the rehabilitation protocols in a personalized and secure way.

In this context, this project proposes to measure the tolerance of volunteers in a specific virtual environment and to quantify the modifications induced by this immersive environment, during a simple locomotor act (walking on flat ground) and complex (walking on a slope) in healthy volunteers, in order to evaluate the impact of VR on locomotion in a healthy population, and then in a second time in lower limb amputee patients

This monocentric study will take place on the Technological Investigation Platform of the Dijon Bourgogne University Hospital.

25 healthy volunteers and 25 lower limb amputees (transtibial or transfemoral) will be included in this study.

The participants will make 3 visits:

* Visit 1 (inclusion visit and analysis of walking on flat ground)
* visit 2 (analysis of walking on slopes): between 15 days and 1 month after visit 1
* visit 3 (group interview with a sociologist): only for patients within 45 days after visit 2

Detailed Description

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Conditions

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Unilateral Amputation of the Lower Limb

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Subjects with lower limb amputations

Group Type EXPERIMENTAL

Analysis of walking on flat ground

Intervention Type OTHER

Analysis of walking on flat ground under different environmental conditions (visit 1)

Hospital Anxiety Disorder Questionnaire

Intervention Type OTHER

performed during the inclusion visit

Analysis of walking on slopes

Intervention Type OTHER

All assessments will be identical to the flat walking analysis: flat walking will be replaced by slope walking for all environmental conditions

Group interview with a sociologist

Intervention Type OTHER

Virtual reality feedback, accompanied by a confrontation of the patients' subjective experiences (group of 5 to 10 people)

Healthy volunteers

Group Type ACTIVE_COMPARATOR

Analysis of walking on flat ground

Intervention Type OTHER

Analysis of walking on flat ground under different environmental conditions (visit 1)

Hospital Anxiety Disorder Questionnaire

Intervention Type OTHER

performed during the inclusion visit

Analysis of walking on slopes

Intervention Type OTHER

All assessments will be identical to the flat walking analysis: flat walking will be replaced by slope walking for all environmental conditions

Interventions

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Analysis of walking on flat ground

Analysis of walking on flat ground under different environmental conditions (visit 1)

Intervention Type OTHER

Hospital Anxiety Disorder Questionnaire

performed during the inclusion visit

Intervention Type OTHER

Analysis of walking on slopes

All assessments will be identical to the flat walking analysis: flat walking will be replaced by slope walking for all environmental conditions

Intervention Type OTHER

Group interview with a sociologist

Virtual reality feedback, accompanied by a confrontation of the patients' subjective experiences (group of 5 to 10 people)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Healthy volunteers:

* Person who has given oral consent
* Male or female over the age of majority, \< 80 years
* Person able to understand simple commands, conditioning instructions

Amputee patients:

* Person who has given oral consent
* Male or female over the age of majority, \< 80 years
* Patients with unilateral transfemoral or transtibial amputation of the lower limb of any origin (traumatic, vascular, congenital or neoplastic) with a definitive device.
* Patients with stable locomotion with aids, without technical aids
* Person able to understand simple orders, conditioning instructions

Exclusion Criteria

Healthy Volunteers:

* Person who is not affiliated or not a beneficiary of a social security system
* Person subject to a legal protection measure (curatorship, guardianship)
* Person subject to a legal protection measure
* Pregnant, parturient or breastfeeding woman
* Major incapable or unable to express his consent
* Minor
* Person with locomotor disorders (orthopedic, neurological, vascular, cardiac...) and/or balance disorders that may significantly alter walking
* Person with a contraindication to wearing a virtual reality helmet (uncontrolled epilepsy, wound of an area that the helmet would cover, severe ophthalmological disorders etc.)

Amputee patients:

* Person who is not affiliated or not a beneficiary of a social security plan
* Person under legal protection (guardianship, trusteeship)
* Person subject to a legal protection measure
* Pregnant, parturient or breastfeeding woman
* Major incapable or unable to express his consent
* Minor
* Person with locomotor disorders (orthopedic, neurological, vascular, cardiac...) other than amputation that may significantly alter walking
* Persons with contraindications to wearing a virtual reality helmet (uncontrolled epilepsy, wounds in an area that the helmet would cover, severe ophthalmological disorders, etc.)
* Patients unable to participate in a group interview (qualitative study only)
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chu Dijon Bourgogne

Dijon, , France

Site Status

Countries

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France

Other Identifiers

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CASILLAS CRBFC-E 2019

Identifier Type: -

Identifier Source: org_study_id