A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer

NCT ID: NCT05634499

Last Updated: 2026-01-13

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-06-27
• Study Completion Date: 2026-06-30

Brief Summary

This Phase II, global, single-arm study is designed to evaluate the efficacy, safety, and pharmacokinetics of giredestrant monotherapy in participants with Grade 1 endometrioid endometrial cancer.

Conditions

Endometrial Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Giredestrant

Group Type: EXPERIMENTAL

Giredestrant

Intervention Type: DRUG

Participants will receive giredestrant 30 milligrams (mg) taken orally (PO) once a day (QD) on Days 1 to 28 of each 28-day cycle for 6 cycles. After completion of 6 cycles, the participant and investigator can choose to continue study treatment for an additional 18 cycles or discontinue study treatment and receive investigator-determined care.

Interventions

Giredestrant

Participants will receive giredestrant 30 milligrams (mg) taken orally (PO) once a day (QD) on Days 1 to 28 of each 28-day cycle for 6 cycles. After completion of 6 cycles, the participant and investigator can choose to continue study treatment for an additional 18 cycles or discontinue study treatment and receive investigator-determined care.

Intervention Type: DRUG

Other Intervention Names

RO7197597; GDC-9545; RG6171

Eligibility Criteria

Inclusion Criteria

• Confirmed Grade 1 endometrial cancer (EC) of endometrioid histology for which participants are willing to receive 6-cycles of study therapy. An endometrial biopsy (EMB) or dilation and curettage (D&C) fresh collected within the screening period or archival sample collected within 3 months prior to screening must be provided to a central laboratory for histologic confirmation to determine eligibility.
• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
• Magnetic resonance imaging (MRI)-confirmation of non-deeply invasive tumor (<50% myometrial invasion)
• MRI or computed tomography (CT)-confirmation of no extrauterine disease
• Willing to undergo a minimum of 6 continuous cycles of therapy before decision on surgery
• No prior treatment for endometrial cancer
• Able and willing to take oral medications
• Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures
• Adequate hematologic and end-organ function, as defined in the protocol
• Negative HIV test at screening, with the following exception: Patients with a positive HIV test at screening are eligible provided they are stable on anti-retroviral therapy, have a CD4 count ≥200/μL, and have an undetectable viral load.
• For female participants of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception, and agree to refrain from donating eggs, during the treatment period and for 30 days after the final dose of giredestrant, as defined in the protocol

Exclusion Criteria

• Pregnancy or breastfeeding, or intention of becoming pregnant during the study or within 30 days after the final dose of giredestrant or within the time period specified per local prescribing guidelines after the final dose of the investigator's choice of endocrine therapy
• Participants with non-endometrioid histologies, such as serous, clear cell, and mixed
• Treatment with investigational therapy within 28 days prior to initiation of study enrollment
• Treatment for cancer including but not limited to, chemotherapy, immunotherapy, cyclin-dependent kinase (CDK)4/6 inhibitors, endocrine therapy, biologic therapy, or herbal therapy within 28 days prior to the initiation of study enrollment
• Any gastrointestinal condition causing malabsorption or obstruction (e.g., celiac sprue, gastric bypass surgery, strictures, adhesions, history of small bowel resection, blind loop syndrome)
• Known hypersensitivity to giredestrant or its excipients
• Known intercurrent illness or psychiatric illness/social situations that will limit compliance with study requirements
• Evidence or high suspicion of metastatic/extrauterine disease at enrollment
• Unwilling or unable to comply with study-related procedures, including all endometrial sampling/biopsies
• Planned surgery, either for the treatment of cancer or any other surgery, during the study treatment period and up to 10 days after the completion of study treatment
• Serious infections requiring IV antibiotics within 7 days prior to initiation of study treatment or any active infection that, in the opinion of the investigator, could impact participant safety
• Participants who have clinically significant liver disease consistent with Child-Pugh Class B or C, including active hepatitis (e.g., hepatitis B virus [HBV] or hepatitis C virus [HCV]), current alcohol abuse, cirrhosis, or positive test for viral hepatitis, as defined in the protocol
• Treatment with strong CYP3A4 inhibitors or inducers within 14 days or 5 drug elimination half-lives (whichever is longer) prior to initiation of study treatment
• Any serious medical condition or abnormality in clinical laboratory tests that precludes the participant's safe participation in and completion of the study
• History of other malignancy within 5 years prior to screening, except for those with an expected negligible risk for metastases or death (e.g., 5-year overall survival 90%) after curative treatment
• Active tuberculosis
• Severe infection per investigator judgment at the time of enrollment, including but not limited to, use of systemic antibiotics, hospitalization for complications of infection, bacteremia, or severe pneumonia, or any active infection that, in the opinion of the investigator, could impact participant safety
• Significant cardiovascular disease, such as cardiac disease New York Heart Association Class II or greater, myocardial infarction, or cerebrovascular accident within 3 months prior to enrollment, unstable arrhythmias, or unstable angina
• Active cardiac disease or history of cardiac dysfunction, as defined in the protocol
• Major surgical procedure other than for diagnosis within 28 days prior to enrollment or anticipation of need for a major surgical procedure during the study
• Prior allogeneic bone marrow transplantation or solid organ transplant
• Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or renders the participant at high risk for treatment complications illnesses or conditions that interfere with the participant's capacity to understand, follow, and/or comply with study procedures

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Hoffmann-La Roche

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Mount Sinai Medical Center

Miami Beach, Florida, United States

Minnesota Oncology Minneapolis

Minneapolis, Minnesota, United States

Englewood Health/Hematology Oncology Practice of Englewood (HOPE)

Englewood, New Jersey, United States

Western Pennsylvania Hospital

Pittsburgh, Pennsylvania, United States

Texas Oncology, P.A. - Fort Worth

Fort Worth, Texas, United States

Virginia Oncology Associates

Norfolk, Virginia, United States

Jewish General Hospital

Montreal, Quebec, Canada

McGill University Health Centre - Glen Site

Montreal, Quebec, Canada

Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS

Meldola, Emilia-Romagna, Italy

Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice

Gliwice, , Poland

Swietokrzyskie Centrum Onkologii

Kielce, , Poland

Countries

United States; Canada; Italy; Poland

Other Identifiers

2022-002443-21

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

2023-504091-23-00

Identifier Type: OTHER

Identifier Source: secondary_id

CO44195

Identifier Type: -

Identifier Source: org_study_id