miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction

NCT ID: NCT05632055

Last Updated: 2022-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2000-08-26

Study Completion Date

2023-08-31

Brief Summary

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The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.

Participants will be retrieved blood sample during first trimester and undergone 100 gm OGTT (oral glucose challenge test) during 24-28 weeks of gestation.

Detailed Description

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Pregnant women who attended antenatal care at Maharaj Nakorn Chiang Mai hospital during first trimester were recruited.

Participants received routine standard prenatal care except,

1. additional blood test during 11-13 week 6 days (Blood was collected for further analysis)
2. performed 75gm OGTT during 24-28 week

Baseline data and pregnancy outcome were reviewed.

Conditions

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Gestational Diabetes

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Pregnancy with GDM

Pregnant women who positive test for 100gm OGTT (abnormal 2 or more blood glucose level according NDDG (National Diabetes Data Group) criteria)

blood draw

Intervention Type OTHER

Blood test for miRNA and FGF21. However, the laboratory result is not reported and not involved in management

Pregnancy without GDM

Pregnant women who negative test for 100gm OGTT

blood draw

Intervention Type OTHER

Blood test for miRNA and FGF21. However, the laboratory result is not reported and not involved in management

Interventions

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blood draw

Blood test for miRNA and FGF21. However, the laboratory result is not reported and not involved in management

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* singleton pregnant women who attend at our clinic in first trimester

Exclusion Criteria

* known underlying disease such as chronic hypertension, pregestational diabetes, SLE
* normal structural fetal anatomical screening
* incomplete obstetric data
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Chiang Mai University

OTHER

Sponsor Role lead

Responsible Party

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Kuntharee Traisrisilp

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Maharaj Nakorn ChiangMai Hospital

Chiang Mai, , Thailand

Site Status

Countries

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Thailand

Other Identifiers

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OBG-2563-07494

Identifier Type: -

Identifier Source: org_study_id

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