Education on BDNF on Pain Levels

NCT ID: NCT05623579

Last Updated: 2023-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-01

Study Completion Date

2025-05-28

Brief Summary

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The promotion of neuroplasticity in conjunction with strategies for restructuring maladaptive cognitions that largely cause the activation of neural networks that contribute to the perpetuation of pain is therefore a fundamental neurophysiological principle for establishing a neurophysiological basis for pain.

perpetuation of pain, is therefore a fundamental neurophysiological principle for establishing physiotherapy therapeutic to establish therapeutic strategies from physiotherapy that contribute to improve the quality of life of patients with chronic pain. patients with chronic pain.

Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and or maintenance of hyperexcitability of central neurons in pain, we consider that the levels of this neurotrophic factor, such as BDNF, may have an important role in the perpetuation of pain.

that the levels of this neurotrophic factor may be modified by the application of a therapeutic education protocol, favoring therapeutic education protocol, favoring a reduction in pain intensity.

Detailed Description

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Conditions

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Chronic Pain Musculoskeletal Pain

Keywords

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BDNF Pain Neuroscience Education Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Intervention

Pain Education plus Exercise

Group Type EXPERIMENTAL

Pain Neuroscience Education

Intervention Type BEHAVIORAL

8 Sessions of different pain education interventions

Exercise

Intervention Type BEHAVIORAL

12 Sessions of Aerobic Exercise

Control

Exercise

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type BEHAVIORAL

12 Sessions of Aerobic Exercise

Interventions

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Pain Neuroscience Education

8 Sessions of different pain education interventions

Intervention Type BEHAVIORAL

Exercise

12 Sessions of Aerobic Exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* males and females aged 18 to 65 years with musculoskeletal pain for a minimum of 3 months
* patients recruited by information pamphlets from the university clinic of the Rey Juan Carlos University, and CSEU La Salle
* not having received physiotherapy treatment for this same process in the last 3 months.
* ability to perform all the clinical tests and to understand the study process, as well as to obtain informed consent.

Exclusion Criteria

\- Systemic, neurological, oncological or inflammatory diseases; psychiatric pathologies, pregnancy, type II diabetes.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universidad Rey Juan Carlos

OTHER

Sponsor Role collaborator

Universidad Autonoma de Madrid

OTHER

Sponsor Role lead

Responsible Party

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Raúl Ferrer-Peña

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Clínica URJC

Alcorcón, Madrid, Spain

Site Status NOT_YET_RECRUITING

IRF La Salle

Madrid, , Spain

Site Status RECRUITING

Countries

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Spain

Facility Contacts

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Josue Fernández-Carnero

Role: primary

Luis Matesanz

Role: primary

References

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Mills SEE, Nicolson KP, Smith BH. Chronic pain: a review of its epidemiology and associated factors in population-based studies. Br J Anaesth. 2019 Aug;123(2):e273-e283. doi: 10.1016/j.bja.2019.03.023. Epub 2019 May 10.

Reference Type BACKGROUND
PMID: 31079836 (View on PubMed)

Andias R, Neto M, Silva AG. The effects of pain neuroscience education and exercise on pain, muscle endurance, catastrophizing and anxiety in adolescents with chronic idiopathic neck pain: a school-based pilot, randomized and controlled study. Physiother Theory Pract. 2018 Sep;34(9):682-691. doi: 10.1080/09593985.2018.1423590. Epub 2018 Jan 10.

Reference Type RESULT
PMID: 29319386 (View on PubMed)

Other Identifiers

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2022A36005

Identifier Type: -

Identifier Source: org_study_id