Trial Outcomes & Findings for PEERS Plus mHealth Enhanced Peer Support (NCT NCT05611996)

NCT ID: NCT05611996

Last Updated: 2025-10-08

Results Overview

Proportion of the participants who complete 80% of their weekly meetings with the peer coach.

Recruitment status

COMPLETED

Study phase

Target enrollment

34 participants

Primary outcome timeframe

18 months

Results posted on

2025-10-08

Participant Flow

Participant milestones

Participant milestones
Measure	Peer Support Older adults who are experiencing depression receive peer support. Peer support consists of emotional and self care support delivered by a peer mentor. Peer mentors are the interventionists and do not receive the intervention. We did not collect any data about peer mentors in the study.
Overall Study STARTED	34
Overall Study COMPLETED	24
Overall Study NOT COMPLETED	10

Reasons for withdrawal

Reasons for withdrawal
Measure	Peer Support Older adults who are experiencing depression receive peer support. Peer support consists of emotional and self care support delivered by a peer mentor. Peer mentors are the interventionists and do not receive the intervention. We did not collect any data about peer mentors in the study.
Overall Study Ineligible	1
Overall Study Withdrawal by Subject	9

Baseline Characteristics

34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Peer Support n=34 Participants Peer mentors who have experienced depression provide social support through video chats and texts for 8 weeks. Peers plus: Peer support intervention in which peer mentors who have experiential knowledge of depression deliver social support through video chats and texts to older adults with depression.
Age, Continuous	66.62 years n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Sex: Female, Male Female	31 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Sex: Female, Male Male	3 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Ethnicity (NIH/OMB) Hispanic or Latino	1 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Ethnicity (NIH/OMB) Not Hispanic or Latino	33 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Race/Ethnicity, Customized Asian	2 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Race/Ethnicity, Customized Black	9 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Race/Ethnicity, Customized White	21 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Race/Ethnicity, Customized Multiracial	2 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Region of Enrollment United States	34 Participants n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.
Patient Health Questionnaire-9	11.32 units on a scale STANDARD_DEVIATION 5.36 • n=5 Participants • 34 participants started the intervention, 28 finished the intervention and 6 dropped during the intervention.

PRIMARY outcome

Timeframe: 18 months

Population: Peer mentors who have experienced depression provide social support through video chats and texts for 8 weeks. Peers plus: Peer support intervention in which peer mentors who have experiential knowledge of depression deliver social support through video chats and texts to older adults with depression.

Proportion of the participants who complete 80% of their weekly meetings with the peer coach.

Outcome measures

Outcome measures
Measure	Peer Support n=34 Participants Peer mentors who have experienced depression provide social support through video chats and texts for 8 weeks. Peers plus: Peer support intervention in which peer mentors who have experiential knowledge of depression deliver social support through video chats and texts to older adults with depression.
Intervention Feasibility	28 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: We assessed PHQ-9 scores as changes across three timepoints: baseline, post study and 3 month follow up. We ran a mixed-effects longitudinal model to examine how PHQ-9 scores changed over 5 months (8 week intervention and 3 month follow up).

Population: Sample sizes varied across the three timepoints due to participant attrition. Some individuals chose not to proceed with the intervention after completing the baseline assessment, while others were lost to follow-up by the post-intervention or 3-month follow-up assessments.

Depression will be assessed with the Patient Health Questionnaire (PHQ-9). The PHQ-9 score is summed from 9 items in the questionnaire, and scores range from 0 to 27. A higher score indicates a worse outcome in depression. A score of 5 indicates mild depressive symptoms, 10 - 14 indicates moderate depression, 15-19 indicates moderately severe depression, and 20-27 indicates severe depression.

Outcome measures

Outcome measures
Measure	Peer Support n=34 Participants Peer mentors who have experienced depression provide social support through video chats and texts for 8 weeks. Peers plus: Peer support intervention in which peer mentors who have experiential knowledge of depression deliver social support through video chats and texts to older adults with depression.
Patient Health Questionnaire-9 Baseline	11.32 score on a scale Standard Deviation 5.36
Patient Health Questionnaire-9 Post Study	9.71 score on a scale Standard Deviation 5.59
Patient Health Questionnaire-9 3 Month Follow Up	8.29 score on a scale Standard Deviation 4.84

Adverse Events

Peer Support

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Jin Hui Joo

Massachusetts General Hospital

Phone: 6177245317

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place