Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

NCT ID: NCT05611931

Last Updated: 2025-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

276 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-18

Study Completion Date

2028-01-31

Brief Summary

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The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST v 1.1\]) after completing at least 12 weeks of platinum-based therapy. A total of 276 participants will be enrolled in the study and randomized in a 1:1 ratio to maintenance therapy with either selinexor or placebo.

Detailed Description

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Conditions

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Endometrial Cancer

Keywords

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Selinexor KPT-330 Advanced or Recurrent Endometrial Carcinoma XPORT-EC ENGOT-EN20 GOG-3083 XPORT-EC-042 p53 wild-type Tumor protein 53 wild-type

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators
Double blind placebo-controlled study

Study Groups

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Selinexor

Participants will receive a fixed dose of selinexor 60 milligrams (mg) oral tablets once weekly (QW) on Days 1, 8, 15, and 22 of each 28-day cycle.

Group Type EXPERIMENTAL

Selinexor

Intervention Type DRUG

Dose: 60 mg (3 tablets); Dosage form: film-coated, immediate-release tablet of 20 mg each; Route of administration: oral

Placebo

Participants will receive matching placebo for selinexor oral tablets QW on Days 1, 8, 15, and 22 of each 28-day cycle.

Group Type PLACEBO_COMPARATOR

Matching Placebo for selinexor

Intervention Type DRUG

Dose:60 mg (3 tablets); Dosage form: film-coated, immediate-release tablet of 20 mg each; Route of administration: oral

Interventions

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Selinexor

Dose: 60 mg (3 tablets); Dosage form: film-coated, immediate-release tablet of 20 mg each; Route of administration: oral

Intervention Type DRUG

Matching Placebo for selinexor

Dose:60 mg (3 tablets); Dosage form: film-coated, immediate-release tablet of 20 mg each; Route of administration: oral

Intervention Type DRUG

Other Intervention Names

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KPT-330

Eligibility Criteria

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Inclusion Criteria

* Adults (Aged ≥ 18 years)
* Histologically confirmed endometrial cancer (endometrioid, serous, undifferentiated, or carcinosarcoma sub-types) that is TP53 wild type by central NGSHistologically confirmed EC including endometrioid, serous, undifferentiated, and carcinosarcoma
* Must have completed at least 12 weeks of platinum-based chemotherapy (with or without immune checkpoint inhibitors), with a confirmed partial or complete response according to RECIST v1.1
* Must be able to initiate C1D1 within 3-8 weeks after last platinum dose
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Adequate bone marrow function and organ function

Exclusion Criteria

* Uterine sarcomas, clear cell or small cell carcinoma with neuroendocrine differentiation
* Palliative radiotherapy administered within 14 days of intended C1D1
* Any gastrointestinal dysfunction that could interfere with the absorption of oral study therapy
* Serious psychiatric or medical conditions that could interfere with study participation or would make study involvement unreasonably hazardous
* Previous treatment with an XPO1 inhibitor
* Stable disease or disease progression after platinum-based chemotherapy
* Pregnancy, breastfeeding, or other legal/ethical restrictions to trial participation
* Known dMMR/MSI-H EC tumors that are medically eligible to receive an immune checkpoint inhibitor
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GOG Foundation

NETWORK

Sponsor Role collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

Sponsor Role collaborator

Belgian Gynaecological Oncology Group

OTHER

Sponsor Role collaborator

North Eastern German Society of Gynaecological Oncology

OTHER

Sponsor Role collaborator

The Central and Eastern European Gynecologic Oncology Group

OTHER

Sponsor Role collaborator

Israeli Society of Gynecologic Oncology

OTHER

Sponsor Role collaborator

Australia New Zealand Gynaecological Oncology Group

OTHER

Sponsor Role collaborator

Multicenter Italian Trials in Ovarian Cancer (MITO)

UNKNOWN

Sponsor Role collaborator

Grupo Español de Investigación en Cáncer de Ovario

OTHER

Sponsor Role collaborator

Hellenic Cooperative Oncology Group (HeCOG)

UNKNOWN

Sponsor Role collaborator

Cancer Trials Ireland (CTI)

UNKNOWN

Sponsor Role collaborator

Mario Negri Gynecologic Oncology group (MaNGO)

OTHER

Sponsor Role collaborator

Karyopharm Therapeutics Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status RECRUITING

Honor Health

Phoenix, Arizona, United States

Site Status RECRUITING

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Site Status RECRUITING

UC DAVIS

Davis, California, United States

Site Status RECRUITING

City of Hope National Medical Center

Duarte, California, United States

Site Status RECRUITING

Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, United States

Site Status WITHDRAWN

City of Hope at Irvine Lennar

Irvine, California, United States

Site Status RECRUITING

Cancer and Blood Specialty Clinic

Los Alamitos, California, United States

Site Status RECRUITING

UCLA - Women's Health Clinical Research Unit

Los Angeles, California, United States

Site Status RECRUITING

Long Beach Memorial Medical Center

Los Angeles, California, United States

Site Status RECRUITING

UC Irvine

Orange, California, United States

Site Status WITHDRAWN

Stanford University

Palo Alto, California, United States

Site Status RECRUITING

California Pacific Medical Center

San Francisco, California, United States

Site Status RECRUITING

Highlands Ranch Hospital

Highlands Ranch, Colorado, United States

Site Status WITHDRAWN

University of Colorado Cancer Center

Highlands Ranch, Colorado, United States

Site Status WITHDRAWN

Broward Health Medical Center

Fort Lauderdale, Florida, United States

Site Status RECRUITING

Mount Sinai Comprehensive Cancer Center

Miami Beach, Florida, United States

Site Status RECRUITING

Advent Health

Orlando, Florida, United States

Site Status RECRUITING

Grady Hospital

Atlanta, Georgia, United States

Site Status RECRUITING

Emory University

Atlanta, Georgia, United States

Site Status RECRUITING

Georgia Cancer Center at Augusta University

Augusta, Georgia, United States

Site Status RECRUITING

Northeast Georgia Medical Center

Gainesville, Georgia, United States

Site Status RECRUITING

Illinois Cancer Specialists

Arlington Heights, Illinois, United States

Site Status RECRUITING

NorthShore University Health System

Evanston, Illinois, United States

Site Status RECRUITING

Northwest Cancer Center

Dyer, Indiana, United States

Site Status RECRUITING

Goshen Health

Goshen, Indiana, United States

Site Status RECRUITING

St Vincent Hospital

Indianapolis, Indiana, United States

Site Status RECRUITING

Memorial Hospital of South Bend

South Bend, Indiana, United States

Site Status RECRUITING

University of Iowa

Iowa City, Iowa, United States

Site Status RECRUITING

Our Lady of the Lake Hospital, Inc.

Baton Rouge, Louisiana, United States

Site Status RECRUITING

LSU Health Sciences Center New Orleans

New Orleans, Louisiana, United States

Site Status RECRUITING

Trials365, LLC

Shreveport, Louisiana, United States

Site Status RECRUITING

Tufts Medical Center

Boston, Massachusetts, United States

Site Status RECRUITING

Karmanos Cancer Institute

Detroit, Michigan, United States

Site Status RECRUITING

USON - Minnesota Oncology Hematology

Minneapolis, Minnesota, United States

Site Status RECRUITING

University of Minnesota

Minneapolis, Minnesota, United States

Site Status RECRUITING

St. Dominic's Gynecologic Oncology

Jackson, Mississippi, United States

Site Status RECRUITING

Midwest Ventures Group HCA MId America Division

Kansas City, Missouri, United States

Site Status RECRUITING

Washington University School of Medicine

St Louis, Missouri, United States

Site Status WITHDRAWN

Intermountain Health St. Vincent Regional Hospital

Billings, Montana, United States

Site Status RECRUITING

Women's Cancer Center of Nevada

Las Vegas, Nevada, United States

Site Status RECRUITING

Center Of Hope

Reno, Nevada, United States

Site Status RECRUITING

Hackensack Meridian Health Jersey Shore University Medical Center

Neptune City, New Jersey, United States

Site Status RECRUITING

Women's Cancer Care Associates, LLC

Albany, New York, United States

Site Status RECRUITING

NYU Langone Hospital-Long Island

Mineola, New York, United States

Site Status RECRUITING

Northwell Health - Zuckerberg Cancer Center

New Hyde Park, New York, United States

Site Status RECRUITING

Mount Sinai Chelsea

New York, New York, United States

Site Status WITHDRAWN

Perlmutter Cancer Center at NYU Langone Health

New York, New York, United States

Site Status RECRUITING

Mount Sinai

New York, New York, United States

Site Status WITHDRAWN

Lenox Hill Hospital

New York, New York, United States

Site Status RECRUITING

Northwell Health - Queens Cancer Center

Rego Park, New York, United States

Site Status RECRUITING

University of Rochester

Rochester, New York, United States

Site Status RECRUITING

Atrium Health Levine Cancer Institute

Charlotte, North Carolina, United States

Site Status RECRUITING

Duke Cancer Center

Durham, North Carolina, United States

Site Status RECRUITING

University of Cincinnati Medical Center

Cincinnati, Ohio, United States

Site Status RECRUITING

MetroHealth

Cleveland, Ohio, United States

Site Status RECRUITING

Zangmeister Cancer Center

Columbus, Ohio, United States

Site Status RECRUITING

ProMedica Flower Hospital

Sylvania, Ohio, United States

Site Status RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Oklahoma Cancer Specialists and Research Institute, LLC

Tulsa, Oklahoma, United States

Site Status RECRUITING

Oncology Associates of Oregon

Eugene, Oregon, United States

Site Status RECRUITING

Providence Portland Medical Center

Portland, Oregon, United States

Site Status RECRUITING

Alliance Cancer Specialists

Langhorne, Pennsylvania, United States

Site Status RECRUITING

Magee - Women's Hospital

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

Allegheny Health Network - West Penn Hospital

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

Avera

Sioux Falls, South Dakota, United States

Site Status RECRUITING

Chattanooga's Program in Women's Oncology

Chattanooga, Tennessee, United States

Site Status WITHDRAWN

The West Clinic, PLLC dba West Cancer Center

Germantown, Tennessee, United States

Site Status WITHDRAWN

University of Tennessee Medical Center

Knoxville, Tennessee, United States

Site Status RECRUITING

University of Tennessee Health Science Center

Memphis, Tennessee, United States

Site Status RECRUITING

USON - Texas Oncology, Austin Central

Austin, Texas, United States

Site Status RECRUITING

Parkland Health & Hospital System

Dallas, Texas, United States

Site Status RECRUITING

Texas Oncology - Dallas

Dallas, Texas, United States

Site Status RECRUITING

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Site Status RECRUITING

Texas Oncology - Fort Worth

Fort Worth, Texas, United States

Site Status WITHDRAWN

Houston Methodist

Houston, Texas, United States

Site Status RECRUITING

Texas Oncology - San Antonio

San Antonio, Texas, United States

Site Status RECRUITING

Texas Oncology - The Woodlands

The Woodlands, Texas, United States

Site Status RECRUITING

Texas Oncology, PC, Tyler

Tyler, Texas, United States

Site Status RECRUITING

University of Utah

Salt Lake City, Utah, United States

Site Status RECRUITING

University of Virginia

Charlottesville, Virginia, United States

Site Status RECRUITING

Swedish Cancer Institute

Seattle, Washington, United States

Site Status RECRUITING

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, United States

Site Status RECRUITING

Medical College of Wisconsin/ Freodtert Hospital

Milwaukee, Wisconsin, United States

Site Status WITHDRAWN

Border Medical Oncology & Haematology

Albury, New South Wales, Australia

Site Status RECRUITING

Macarthur Cancer Therapy Centre

Campbelltown, New South Wales, Australia

Site Status RECRUITING

Chris O'Brien Lifehouse

Camperdown, New South Wales, Australia

Site Status RECRUITING

Central Coast LHD - Gosford & Wyong Hospitals

Gosford, New South Wales, Australia

Site Status RECRUITING

Newcastle Private Hospital

New Lambton Heights, New South Wales, Australia

Site Status RECRUITING

Royal North Shore Hospital

Saint Leonards, New South Wales, Australia

Site Status RECRUITING

Westmead Hospital

Wentworthville, New South Wales, Australia

Site Status RECRUITING

ICON Cancer Centre Southport

Southport, Queensland, Australia

Site Status RECRUITING

Toowoomba Hospital

Toowoomba, Queensland, Australia

Site Status RECRUITING

Royal Hobart Hospital

Hobart, Tasmania, Australia

Site Status RECRUITING

Box Hill Hospital - Eastern Health (Oncology)

Box Hill, Victoria, Australia

Site Status RECRUITING

Monash Health

Clayton, Victoria, Australia

Site Status RECRUITING

Frankston Hospital

Frankston, Victoria, Australia

Site Status RECRUITING

Cabrini Health

Malvern, Victoria, Australia

Site Status RECRUITING

Peter MacCallum Cancer Centre/RWH/RMH

Melbourne, Victoria, Australia

Site Status WITHDRAWN

The Royal Adelaide Hospital

Southport, , Australia

Site Status RECRUITING

Cliniques Universitaires St. Luc

Brussels, , Belgium

Site Status RECRUITING

AZ Sint Lucas

Ghent, , Belgium

Site Status RECRUITING

UZ Leuven

Leuven, , Belgium

Site Status RECRUITING

CHU Ambroise Pare

Mons, , Belgium

Site Status RECRUITING

CHU UCL Namur, Site Sainte-Elisabeth

Namur, , Belgium

Site Status RECRUITING

Tom Baker Cancer Centre

Calgary, Alberta, Canada

Site Status RECRUITING

Cross Cancer Institute

Edmonton, Alberta, Canada

Site Status NOT_YET_RECRUITING

Nova Scotia Health / QEII Health Sciences Centre / Atlantic Clinical Cancer Research Unit

Halifax, Nova Scotia, Canada

Site Status RECRUITING

Princess Margaret

Toronto, Ontario, Canada

Site Status RECRUITING

Sunnybrook Research Institute

Toronto, Ontario, Canada

Site Status RECRUITING

Centre Hospitalier de l'Université de Montréal

Montreal, Quebec, Canada

Site Status RECRUITING

McGill University Health Centre (MUHC)

Montreal, Quebec, Canada

Site Status RECRUITING

Hospital Maisonneuve-Rosemont

Montreal, Quebec, Canada

Site Status RECRUITING

University Hospital Brno

Brno, , Czechia

Site Status RECRUITING

University Hospital Ostrava

Ostrava, , Czechia

Site Status RECRUITING

UH Královské Vinohrady

Prague, , Czechia

Site Status RECRUITING

General University Hospital in Prague

Prague, , Czechia

Site Status RECRUITING

Hospital Na Bulovce

Prague, , Czechia

Site Status RECRUITING

High Technology Hospital Medcenter

Batumi, , Georgia

Site Status RECRUITING

Todua Clinic

Tbilisi, , Georgia

Site Status RECRUITING

LTD New Hospitals

Tbilisi, , Georgia

Site Status RECRUITING

Tbilisi Cancer Center

Tbilisi, , Georgia

Site Status RECRUITING

JSC - K.Eristavi National Center of Experimental and Clinical Surgery

Tbilisi, , Georgia

Site Status RECRUITING

Caucasus Medical Centre

Tbilisi, , Georgia

Site Status RECRUITING

LTD Innova Medical Center

Tbilisi, , Georgia

Site Status RECRUITING

Multiprofile Clinic "Consilium Medulla"

Tbilisi, , Georgia

Site Status RECRUITING

Charite Berlin Universitatsmedizin

Berlin, , Germany

Site Status RECRUITING

Universitätsklinikum Hamburg Eppendorf

Hamburg, , Germany

Site Status RECRUITING

University Hospital Dresden

Kiel, , Germany

Site Status RECRUITING

Universitatsklinikum Schleswig-Holstein

Kiel, , Germany

Site Status RECRUITING

Helios Klinikum Krefeld

Krefeld, , Germany

Site Status RECRUITING

Universitätsklinik Leipzig

Leipzig, , Germany

Site Status RECRUITING

Universitätsfrauenklinik Mainz

Mainz, , Germany

Site Status NOT_YET_RECRUITING

Universitätsmedizin Mannheim

Mannheim, , Germany

Site Status RECRUITING

Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe GroBhadern

Munich, , Germany

Site Status RECRUITING

Klinikum Südstadt Rostock

Rostock, , Germany

Site Status RECRUITING

Universitätsfrauenklinik Ulm

Ulm, , Germany

Site Status RECRUITING

IASO Hospital

Marousi, Athens, Greece

Site Status RECRUITING

Alexandra Hospital

Athens, , Greece

Site Status RECRUITING

Hygeia Hospital

Athens, , Greece

Site Status RECRUITING

Euromedica General Clinic

Thessaloniki, , Greece

Site Status RECRUITING

Unit of Gynecol.Oncol., Dept.Obstet.Gynecol., Clinical Center, University of Debrecen

Debrecen, , Hungary

Site Status RECRUITING

Petz Aladár University Teaching Hospital

Győr, , Hungary

Site Status RECRUITING

St. Vincent's University Hospital

Dublin, Elm Park, Ireland

Site Status NOT_YET_RECRUITING

Cork University Hospital

Cork, , Ireland

Site Status RECRUITING

St. James Hospital

Dublin, , Ireland

Site Status RECRUITING

Galway University

Galway, , Ireland

Site Status RECRUITING

University Hospital Waterford

Waterford, , Ireland

Site Status RECRUITING

Hillel-Yaffe Medical Center

Hadera, , Israel

Site Status RECRUITING

Wolfson Medical Center

Holon, , Israel

Site Status RECRUITING

Hadassah Medical Center

Jerusalem, , Israel

Site Status RECRUITING

Sheba Medical Center

Ramat Gan, , Israel

Site Status RECRUITING

IRCCS Azienda Ospedaliero Universitaria di Bologna

Bologna, , Italy

Site Status RECRUITING

ASST Spedali Civili Di Brescia

Brescia, , Italy

Site Status RECRUITING

IRCCS Istituto Romagnolo Per Lo Studio Del Tumori "Dino Amadori" - IRST S.R.L.

Meldola, , Italy

Site Status RECRUITING

San Raffaele Hospital

Milan, , Italy

Site Status RECRUITING

Istituto Nazionale dei Tumori IRCCS - MILANO S. C. Ginecologia Oncologica

Milan, , Italy

Site Status RECRUITING

Instituto Europeo di Oncologia

Milan, , Italy

Site Status RECRUITING

Humanitas San Pio X Hospital

Milan, , Italy

Site Status RECRUITING

Ospedale San Gerardo - Asst Monza

Monza, , Italy

Site Status RECRUITING

"Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" - NAPOLI Struttura Complessa Oncologia Medica Uro-Ginecologica"

Napoli, , Italy

Site Status RECRUITING

Istituto Oncologico Veneto

Padua, , Italy

Site Status RECRUITING

Universita di Pisa

Pisa, , Italy

Site Status RECRUITING

Nuovo Ospedale di Prato

Prato, , Italy

Site Status RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli - ROMA

Roma, , Italy

Site Status RECRUITING

Ospedale Ostetrico Ginecologico Sant'Anna

Torino, , Italy

Site Status RECRUITING

AO Ordine Mauriziano

Torino, , Italy

Site Status RECRUITING

St. Elisabeth Cancer Institute

Bratislava, , Slovakia

Site Status RECRUITING

UH Bratislava

Bratislava, , Slovakia

Site Status RECRUITING

National Cancer Institute

Bratislava, , Slovakia

Site Status RECRUITING

UH Trenčín

Trenčín, , Slovakia

Site Status RECRUITING

Soon Chun Hyang University Hospital Cheonan

Cheonan, Chungcheongnam-do, South Korea

Site Status RECRUITING

Severance Hospital (Yonsei University Health System)

Seoul, Seongbuk, South Korea

Site Status RECRUITING

Samsung Changwon Hospital

Changwon, , South Korea

Site Status RECRUITING

National Cancer Center (NCC)

Goyang-si, , South Korea

Site Status RECRUITING

CHA University/Bundang CHA General Hospital

Seongnam-si, , South Korea

Site Status NOT_YET_RECRUITING

Seoul National University Hospital

Seoul, , South Korea

Site Status RECRUITING

Gangnam Severance Hospital

Seoul, , South Korea

Site Status RECRUITING

Seoul St. Mary's Hospital

Seoul, , South Korea

Site Status NOT_YET_RECRUITING

Seoul National University Bundang Hospital

Seoul, , South Korea

Site Status RECRUITING

Korea University Anam Hospital

Seoul, , South Korea

Site Status RECRUITING

Samsung Medical Center

Seoul, , South Korea

Site Status RECRUITING

Asan Medical Center

Seoul, , South Korea

Site Status RECRUITING

Hospital Universitario Donostia

Donostia / San Sebastian, Gipuzkoa, Spain

Site Status RECRUITING

Hospital Clínico Universitario Lozano Blesa

Zaragoza, Zaragoza, Spain

Site Status RECRUITING

ICO Badalona

Badalona, , Spain

Site Status RECRUITING

Hospital Universitari Vall d' Hebrón

Barcelona, , Spain

Site Status RECRUITING

Hospital Clinic de Barcelona

Barcelona, , Spain

Site Status RECRUITING

Institut Catala d'Oncologia Hospitalet

Barcelona, , Spain

Site Status RECRUITING

Hospital Universitario Reina Sofía

Córdoba, , Spain

Site Status RECRUITING

Institut Catala d'Oncologia de Girona

Girona, , Spain

Site Status RECRUITING

Hospital Universitario Virgen de las Nieves

Granada, , Spain

Site Status RECRUITING

MD Anderson Cancer Center Madrid

Madrid, , Spain

Site Status RECRUITING

Hospital Universitario Ramón y Cajal

Madrid, , Spain

Site Status RECRUITING

Hospital Universitario Clinico San Carlos

Madrid, , Spain

Site Status RECRUITING

H 12 de Octubre

Madrid, , Spain

Site Status RECRUITING

Hospital Universitario La Paz

Madrid, , Spain

Site Status RECRUITING

Hospital Universitatrio Virgen de la Victoria

Málaga, , Spain

Site Status RECRUITING

Virgen de la Arrixaca University Clinical Hospital

Murcia, , Spain

Site Status RECRUITING

Hospital Universitario Virgen del Rocío

Seville, , Spain

Site Status RECRUITING

Instituto Valenciano de Oncología

Valencia, , Spain

Site Status RECRUITING

Hospital Clínico Universitario de Valencia

Valencia, , Spain

Site Status RECRUITING

Hospital LaFe Uacenlia

Valencia, , Spain

Site Status RECRUITING

Hospital Miguel Servet

Zaragoza, , Spain

Site Status RECRUITING

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

Site Status RECRUITING

TaiChung Veterans General Hospital

Taichung, , Taiwan

Site Status RECRUITING

Chi Mei Medical Center

Tainan, , Taiwan

Site Status RECRUITING

Mackay Memorial Hospital

Taipei, , Taiwan

Site Status RECRUITING

Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status RECRUITING

Taipei Medical University- Shuang Ho Hospital, Ministry of Health and Welfare

Taipei, , Taiwan

Site Status RECRUITING

Chang Gung Memorial Hospital

Taoyuan, , Taiwan

Site Status RECRUITING

Ankara Baskent Hospital

Çankaya, Ankara, Turkey (Türkiye)

Site Status RECRUITING

Ankara University

Yenimahalle, Ankara, Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Istanbul University Capa Hospital

Fatih, Istanbul, Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Çukurova University

Adana, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Adana Baskent Hospital

Adana, , Turkey (Türkiye)

Site Status RECRUITING

Hacettepe University Oncology Hospital

Ankara, , Turkey (Türkiye)

Site Status RECRUITING

Memorial Ankara Hospital

Ankara, , Turkey (Türkiye)

Site Status RECRUITING

Cerrahpasa University

Istanbul, , Turkey (Türkiye)

Site Status NOT_YET_RECRUITING

Acibadem Atakent Hospital

Istanbul, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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United States Australia Belgium Canada Czechia Georgia Germany Greece Hungary Ireland Israel Italy Slovakia South Korea Spain Taiwan Turkey (Türkiye)

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Karyopharm Medical Information

Role: CONTACT

Phone: (888) 209-9326

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Anna Wilbanks

Role: primary

Mei Yu

Role: primary

Mary Blaine

Role: primary

Rebecca Brooks

Role: primary

Hesham Mahmoud

Role: primary

Hesham Mahmoud

Role: primary

Arati Chand

Role: primary

Rachel Gray

Role: primary

Laura Macias

Role: primary

Bela Shah

Role: primary

Julia Rivera Penafiel

Role: primary

Toni Rodriquez

Role: primary

Krystal Olivera

Role: primary

Robert Holloway

Role: primary

Ashley Trumbull

Role: primary

Nina Kimball

Role: primary

Donna Wheatley

Role: primary

Trena Davis

Role: primary

Laura Lozano

Role: primary

Maria Velez

Role: primary

Kirsten Becker

Role: primary

Pamela Stone

Role: primary

Cynthia Cruz Rivera

Role: primary

Amie Lake

Role: primary

David Bender

Role: primary

Tammy Hines

Role: primary

Cambri Moeller

Role: primary

Carrie Kay

Role: primary

Jill Marshall

Role: primary

Allison Wolgast

Role: primary

Lauren Bollinger

Role: primary

Britt Erickson

Role: primary

Khadijra Lockwood

Role: primary

Megan Werner

Role: primary

Megan Peterson

Role: primary

Jacky Amador

Role: primary

Shannon Pierpoint

Role: primary

Danielle Kwiatkowski

Role: primary

Nicolina Suriano

Role: primary

Karen Estok

Role: primary

Joan Tymon-Rosario

Role: primary

Keith Kallas

Role: primary

Joan Tymon-Rosario

Role: primary

Joan Tymon-Rosario

Role: primary

Jamie Littletom

Role: primary

Tesa Adams

Role: primary

Jennifer Mewshaw

Role: primary

Cara King

Role: primary

Kimberly Resnick

Role: primary

Nancy Zangmeister

Role: primary

Kendra Mann

Role: primary

Christine Pappaterra

Role: primary

Michael Gold

Role: primary

Tawna Kiely

Role: primary

Nora Auston

Role: primary

Veronica Puac

Role: primary

Kelsey Mitch

Role: primary

Siobhan Guyach

Role: primary

Teri Kayl

Role: primary

Krissy Bolig

Role: primary

Suzhen Gong

Role: primary

Helen Eshed

Role: primary

Annette Paulsen

Role: primary

Dominique Marquez

Role: primary

Annette Paulsen

Role: primary

Jaya Kamath

Role: primary

Ben Singh

Role: primary

Taryn Davis

Role: primary

Angela Jennings

Role: primary

Theresa Werner

Role: primary

Rachel Lacy

Role: primary

Fernanda Musa

Role: primary

Claire Kostechka

Role: primary

Jacqui McBurnie

Role: primary

Felicia Roncolato

Role: primary

Jacquie Harvey

Role: primary

Richard Clayton

Role: primary

Julie Charlton

Role: primary

Sally McCowatt

Role: primary

Meenal Rai

Role: primary

Monica Reay

Role: primary

Elizabeth Ratcliffe

Role: primary

Holly Price

Role: primary

Karen Lim

Role: primary

Karen Gillett

Role: primary

Judi Clarke

Role: primary

Koby Scarff

Role: primary

Anne Milton

Role: primary

Florence Fontaine

Role: primary

Sarah Van Damme

Role: primary

Lauren van den Eynde

Role: primary

Marianne Blockmans

Role: primary

Benedicte Hyernaux

Role: primary

Prafull Ghatage

Role: primary

Jennifer Rauw

Role: primary

Alison Avery

Role: primary

Lila Shapiro

Role: primary

Nithla Mohanathas

Role: primary

Bonny Choy

Role: primary

Nathalie Nguyen-Phuong-Nam

Role: primary

Suzanne Fortin

Role: primary

Katerina Polanska

Role: primary

Aneta Nenickova

Role: primary

Katerina Havlikova

Role: primary

Anna Svatonova

Role: primary

Hana Urbankova

Role: primary

Mamuka Sikharulidze

Role: primary

Tamar Melkadze

Role: primary

Davit Giorgadze

Role: primary

Nino Kapanadze

Role: primary

Nata Murusidze

Role: primary

Aleksandre Iovashivili

Role: primary

Nino Khunashvili

Role: primary

Megi Kamadadze

Role: primary

Isil Yalcinkaya

Role: primary

Esther Freese

Role: primary

Olga Schubert

Role: primary

Tobias Schmidt

Role: primary

Andrea Weggen

Role: primary

Christine Gimpel

Role: primary

Martina Seehase

Role: primary

Daniela Hoeyer

Role: primary

Bettina Gansneder

Role: primary

Beatrice Engel

Role: primary

Heike Karl

Role: primary

Aggeliki Konte

Role: primary

Panagiota Zaharaki

Role: primary

Sofia Brebou

Role: primary

Anatsasia Kitka

Role: primary

Krisztina Szabolcsy

Role: primary

Marta Haszonitsne Janoki

Role: primary

Fausta Barizaite

Role: primary

Edel Hassett

Role: primary

Emily Foley

Role: primary

Cassandra Phan

Role: primary

Elaine Shanahan

Role: primary

Kasanesh Redai

Role: primary

Gali Borntnik

Role: primary

Rivka Ashlem

Role: primary

Revital Levit

Role: primary

Cinzia Pizzirani

Role: primary

Eliana Bignotti

Role: primary

Eleonora Paoletti

Role: primary

Giorgia Lupi

Role: primary

Dominique Ronzulli

Role: primary

Abbondanza Montinaro

Role: primary

Serena Giolitto

Role: primary

Riccardo Artuso

Role: primary

Margherita Tambaro

Role: primary

Giulia Doria

Role: primary

Stefania Cosio

Role: primary

Francesca Del Monte

Role: primary

Chiara Altavilla

Role: primary

Stefano Fucina

Role: primary

Noemi Alu

Role: primary

Vera Novotna

Role: primary

Mikulas Redecha

Role: primary

Daniela Světlovská

Role: primary

Luboslava Hiresova

Role: primary

Seob Jeon

Role: primary

Sang-Wun Kim

Role: primary

Min Kyu Kim

Role: primary

Myong Cheoi Lim

Role: primary

Min Chul Choi

Role: primary

Hyun Hoon Chung

Role: primary

Jae-hoon Kim

Role: primary

Keun Ho Lee

Role: primary

KiDong Kim

Role: primary

Jae-Yun Song

Role: primary

Yoo-Young Lee

Role: primary

Daeyeon Kim

Role: primary

Maria Hidalgo

Role: primary

Isabel Huercanos

Role: primary

Judith Rodriguez

Role: primary

Ana Matres

Role: primary

Laura Berengue

Role: primary

Daniel Plana

Role: primary

Maria Jose Marin

Role: primary

Nuria Martin

Role: primary

Elisabet Maza Serrano

Role: primary

Belén Bautista

Role: primary

Maria Canton

Role: primary

Helena Olivera Frade

Role: primary

Rosa Rodriquez

Role: primary

Yolanda Álvarez

Role: primary

Juan Carlos Ruiz

Role: primary

Paula Ruiz

Role: primary

Laura Bernal

Role: primary

Belen Vazquez

Role: primary

Inma Blasco

Role: primary

Marian Lavin

Role: primary

Concepcion Velazquez

Role: primary

Hao Lin

Role: primary

Chien-Hsing Lu

Role: primary

Wei-Yu Chen

Role: primary

Jen-Ruei Chen

Role: primary

Wen-Hsun Chang

Role: primary

Hung-Cheng Lai

Role: primary

Ting-Chang Chang

Role: primary

Nejat Ozgul

Role: primary

Yuksel Urun

Role: primary

Pinar Saip

Role: primary

Ganim Khatib

Role: primary

Fatih Kose

Role: primary

Zafer Arik

Role: primary

Umut Demirci

Role: primary

Oguzhan Kuru

Role: primary

M. Faruk Kose

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Secord AA, Powell MA, McAlpine J. Molecular Characterization and Clinical Implications of Endometrial Cancer. Obstet Gynecol. 2025 Nov 1;146(5):660-671. doi: 10.1097/AOG.0000000000006080. Epub 2025 Sep 18.

Reference Type DERIVED
PMID: 40966692 (View on PubMed)

Makker V, Perez-Fidalgo JA, Valabrega G, Hamilton E, Van Gorp T, Sehouli J, Reginacova K, Richardson DL, Perri T, Oza AM, Miller DS, Alia EMG, De Giorgi U, Henry S, Spitz DL, Wimberger P, Bednarikova M, Chon HS, Martinez-Garcia J, Pisano C, Berek JS, Romero I, Scambia G, Farinas-Madrid L, Buscema J, Schochter F, Li K, Kalyanapu P, Walker CJ, Vergote I. Long-term follow-up of efficacy and safety of selinexor maintenance treatment in patients with TP53wt advanced or recurrent endometrial cancer: A subgroup analysis of the ENGOT-EN5/GOG-3055/SIENDO study. Gynecol Oncol. 2024 Jun;185:202-211. doi: 10.1016/j.ygyno.2024.05.016. Epub 2024 Jun 3.

Reference Type DERIVED
PMID: 38834399 (View on PubMed)

Vergote I, Perez Fidalgo A, Valabrega G, Monk BJ, Herzog T, Cibula D, Colombo N, Pothuri B, Sehouli J, Korach J, Barlin J, Papadimitriou CA, van Gorp T, Richardson D, McCarthy M, Antill Y, Mirza MR, Li K, Kalyanapu P, Slomovitz B, Coleman RL. ENGOT-EN20/GOG-3083/XPORT-EC-042 - A phase III, randomized, placebo-controlled, double-blind, multicenter trial of selinexor in maintenance therapy after systemic therapy for patients with p53 wild-type, advanced, or recurrent endometrial carcinoma: rationale, methods, and trial design. Int J Gynecol Cancer. 2024 Aug 5;34(8):1283-1289. doi: 10.1136/ijgc-2024-005412.

Reference Type DERIVED
PMID: 38627035 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

GOG-3083

Identifier Type: OTHER

Identifier Source: secondary_id

ENGOT-EN20

Identifier Type: OTHER

Identifier Source: secondary_id

XPORT-EC-042

Identifier Type: -

Identifier Source: org_study_id