Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood Biomarkers

NCT ID: NCT05603819

Last Updated: 2024-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

418 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-29

Study Completion Date

2024-09-30

Brief Summary

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Differentiation between major depressive disorder (MDD) and bipolar disorder (BD) as soon as possible in the patient journey represents a major clinical issue. When the patient is in a depressive phase, the symptoms are similar between the two pathologies and the current clinical scales fail in distinguishing them. Physicians often report this difficulty and as a consequence, the mean time from onset to bipolar disorder diagnosis is currently 7.5 years. These diagnostic delays and misdiagnosis lead to damaging consequences for patients and their loved ones: worsening of symptoms, comorbidities, suicide risk and inadequate care resulting in severe impairment in social and occupational functioning. Faced with these high expectations for accurate diagnostic methods for an earlier management of psychiatric patients, the combination of relevant clinical features and biomarkers could stand for a solution, leading to a personalised approach in patients with mood disorders.

In a first clinical discovery study, a panel of RNA biomarkers in the blood of patients with a major depressive episode (MDE) has been identified, allowing to differentiate bipolar disorder from MDD (unipolar depression). These biomarkers are based on RNA modifications, namely RNA editing, that could be identified using molecular biology, NGS and artificial intelligence. This panel constitutes EDIT-B test, which is based on Alcediag's proprietary and patented biomarkers and algorithms.

The present study aims to validate the biomarker signatures proposed by Alcediag by measuring the association between the modifications of the RNA editing and major depressive disorder/ bipolar disorder diagnosis, in patients with a MDE in real-life setting pilot centres.

Detailed Description

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Conditions

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Bipolar Disorder Major Depressive Disorder

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Bipolar disorder

Patients with depression suffering from bipolar disorder.

EDIT-B

Intervention Type DEVICE

To perform EDIT-B test, questionnaires and 2x0.5 mL whole blood are collected from each patient.

Major depressive disorder

Patients with depression suffering from major depressive disorder.

EDIT-B

Intervention Type DEVICE

To perform EDIT-B test, questionnaires and 2x0.5 mL whole blood are collected from each patient.

Interventions

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EDIT-B

To perform EDIT-B test, questionnaires and 2x0.5 mL whole blood are collected from each patient.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Signed informed consent.
2. Male or female ≥ 18 and ≤ 80 years of age at inclusion.
3. MADRS ≥ 20
4. In- and out-patients can be recruited.
5. Diagnosed with MDE with the MINI for DSM-5
6. Currently treated for the MDE
7. Diagnosed with MDD or BD with the MINI for DSM-5.
8. For patients with BD: at least one manic or hypomanic episode
9. For patients with MDD: at least one MDE

Exclusion Criteria

1. MDD patients with first degree family history of bipolar disorder
2. YMRS \> 12
3. Pregnant women
4. Unipolar or bipolar depression secondary to major central nervous system affections, including infections in the brain, tumours of the brain, stroke, Alzheimer's disease, Parkinson's disease, Multiple sclerosis, other major brain affections
5. Schizo-affective patients

Abbrevations:

BD Bipolar Disorder DSM-5 Diagnostic and Statistical Manual of Mental disorders 5 MADRS Montgomery-Asberg Depression Rating Scale MDD Major Depressive Disorder MDE Major Depressive Episode MINI Mini-International Neuropsychiatric Interview YMRS Young Mania Rating Scale
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Clinic of Barcelona

OTHER

Sponsor Role collaborator

Fundacion Clinic per a la Recerca Biomédica

OTHER

Sponsor Role collaborator

Region Capital Denmark

OTHER

Sponsor Role collaborator

GHU Paris Psychiatry & Neurosciences

OTHER

Sponsor Role collaborator

Parc Sanitari Sant Joan de Déu

OTHER

Sponsor Role collaborator

Fundació Sant Joan de Déu

OTHER

Sponsor Role collaborator

Synlab Italie

UNKNOWN

Sponsor Role collaborator

Alcediag

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eduard Vieta

Role: PRINCIPAL_INVESTIGATOR

Hospital Clinic of Barcelona

Locations

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The Capital Region of Denmark

Copenhagen, , Denmark

Site Status

GHU Paris Psychiatrie & Neurosciences

Paris, , France

Site Status

Parc Sanitari Sant Joan de Déu

Sant Boi de Llobregat, Barcelona, Spain

Site Status

Hospital Clínic de Barcelona

Barcelona, , Spain

Site Status

Countries

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Denmark France Spain

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Other Identifiers

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EDIT-B

Identifier Type: -

Identifier Source: org_study_id