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Predictors of Acute and Persistent Postoperative Pain in Lung Cancer Surgery

NCT ID: NCT05599386

Last Updated: 2023-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-01

Study Completion Date

2024-08-06

Brief Summary

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The aim of this observational study is to investigate if preoperative quantitative sensory testing, anxiety and depression symptoms, and biological markers are associated with the risk of developing acute and chronic postoperative pain after video-assisted Thoracoscopic surgery (VATS).

Detailed Description

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This observational study examine acute and chronic postoperative pain in patients undergoing VATS. In the study preoperative biomarkers, quantitative sensory testing and questionnaires are used to create prediction models for acute and chronic postoperative pain. The study will serve as background information on the risk factors and predictive factors as well as an exploration of the impact of surgical stress from VATS on circulation microRNA and inflammatory mediators.

Conditions

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Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients Undergoing VATS

Only one group as primary endpoints are continous

Preoperative test

Intervention Type DIAGNOSTIC_TEST

Patients are subject to quantitative sensory testing, questionnaires, and biomarker analysis prior to surgery.

Interventions

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Preoperative test

Patients are subject to quantitative sensory testing, questionnaires, and biomarker analysis prior to surgery.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Adults independent of sex with an age of ≥ 18 years
* Patients scheduled for VATS as a part of either examination or radical treatment of lung cancer

Exclusion Criteria

* Patients who are unable to understand oral and written information.
* Patients with known chronic pain in the thorax which have been persisting for at least six months before the day of surgery.
* Pregnant and nursing women.
* Patients receiving a planned preoperative epidural blockade during their stay.
* Patients converted to open surgery.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aalborg University

OTHER

Sponsor Role collaborator

Jannie Bisgaard Stæhr

OTHER

Sponsor Role lead

Responsible Party

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Jannie Bisgaard Stæhr

Chief Physician

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Jannie Bisagaard, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Aalborg University Hospital

Locations

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Aalborg University Hospital

Aalborg, Region of Northern Jutland, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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AAUH-VATS-02

Identifier Type: -

Identifier Source: org_study_id