Trial Outcomes & Findings for Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents (NCT NCT05597865)

NCT ID: NCT05597865

Last Updated: 2025-12-02

Results Overview

Percentage of participants completing the study at 6 months

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 95 participants
• Primary outcome timeframe: Baseline and 6 months
• Results posted on: 2025-12-02

Participant Flow

Participant milestones

Measure	Alcohol and Drug Use Risk Reduction Arm Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Overall Study STARTED	46	49
Overall Study COMPLETED	44	46
Overall Study NOT COMPLETED	2	3

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents

Baseline characteristics by cohort

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.	Total n=95 Participants Total of all reporting groups
Age, Continuous	21.8 years STANDARD_DEVIATION 2.21 • n=121 Participants	22.0 years STANDARD_DEVIATION 1.90 • n=122 Participants	21.9 years STANDARD_DEVIATION 2.0 • n=243 Participants
Sex: Female, Male Female	32 Participants n=121 Participants	31 Participants n=122 Participants	63 Participants n=243 Participants
Sex: Female, Male Male	14 Participants n=121 Participants	18 Participants n=122 Participants	32 Participants n=243 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=121 Participants	0 Participants n=122 Participants	0 Participants n=243 Participants
Race (NIH/OMB) Asian	0 Participants n=121 Participants	0 Participants n=122 Participants	0 Participants n=243 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=121 Participants	0 Participants n=122 Participants	0 Participants n=243 Participants
Race (NIH/OMB) Black or African American	46 Participants n=121 Participants	49 Participants n=122 Participants	95 Participants n=243 Participants
Race (NIH/OMB) White	0 Participants n=121 Participants	0 Participants n=122 Participants	0 Participants n=243 Participants
Race (NIH/OMB) More than one race	0 Participants n=121 Participants	0 Participants n=122 Participants	0 Participants n=243 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=121 Participants	0 Participants n=122 Participants	0 Participants n=243 Participants

PRIMARY outcome

Timeframe: Baseline and 6 months

Percentage of participants completing the study at 6 months

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants Completing the Study at 6 Months	44 Participants	46 Participants

PRIMARY outcome

Timeframe: Baseline

Number of participants enrolling in the study at baseline

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Number of Participants Enrolling in the Study at Baseline	44 Participants	46 Participants

SECONDARY outcome

Timeframe: baseline

Percentage of participants that self-reported use of any drug in last 3 months at the baseline assessment . Any of the drugs in the list of substances specified in the NIDA-Modified ASSIST questionnaire.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants That Self-reported Use of Any Drug in the Last 3 Months at the Baseline Assessment	25 Participants	31 Participants

SECONDARY outcome

Timeframe: 6 month follow-up

Percentage of participants that self-reported use of any drug in last 3 months at the 6-month assessment. Any of the drugs in the list of substances specified in the NIDA-Modified ASSIST questionnaire.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants That Self-reported Use of Any Drug in Last 3 Months at the 6-month Assessment	21 Participants	24 Participants

SECONDARY outcome

Timeframe: Baseline

Population: Score from Optimism scale

Optimism scale measures hope that something good is going to happen in the future. Total score ranges from 9 to 45. Items were rated on a 5-item scale with higher scores are indicative of higher levels of optimism.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Optimism Scale Total Score at Baseline	38.5 score Standard Deviation 5.7	38.8 score Standard Deviation 5.4

SECONDARY outcome

Timeframe: 6 months

Optimism scale measures hope that something good is going to happen in the future. Total score ranges from 9 to 45. Items were rated on a 5-item scale with higher scores are indicative of higher levels of optimism.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Optimism Scale Total Score at 6 Months	39.5 score Standard Deviation 4.4	39.3 score Standard Deviation 4.8

SECONDARY outcome

Timeframe: Baseline

Beck Hopelessness Scale total score at baseline is a 20-item scale that assesses negative expectations about the future. The total score ranges from 0-20. Higher scores indicate greater levels of hopelessness (more negative expectations about the future, less motivation, more pessimism.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Beck Hopelessness Scale Total Score at Baseline	4.6 score Standard Deviation 2.2	5.2 score Standard Deviation 3.0

SECONDARY outcome

Timeframe: 6 months

Beck Hopelessness Scale total score at baseline is a 20-item scale that assesses negative expectations about the future. The total score ranges from 0-20. Higher scores indicate greater levels of hopelessness (more negative expectations about the future, less motivation, more pessimism.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Beck Hopelessness Scale Total Score at 6 Months	5.2 score Standard Deviation 3.0	4.4 score Standard Deviation 2.4

SECONDARY outcome

Timeframe: baseline

Center for Epidemiological Studies Depression Scale (CES-D). Total score range from 0-60. Higher scores indicate greater severity of depressive symptoms.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Depressive Symptoms Total Score at Baseline	38.1 score Standard Deviation 10.8	37.6 score Standard Deviation 9.5

SECONDARY outcome

Timeframe: 6 months

Center for Epidemiological Studies Depression Scale (CES-D). Total score range from 0-60. Higher scores indicate greater severity of depressive symptoms.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Depressive Symptom Total Score at 6 Months	37.6 score Standard Deviation 9.2	37.1 score Standard Deviation 9.1

SECONDARY outcome

Timeframe: baseline

Percentage of participants that self-reported use of any drug in last 12 months at the baseline assessment. Any of the drugs in the list of substances specified in the NIDA-Modified ASSIST questionnaire.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants That Self-reported Use of Any Drug in Last 12 Months at the Baseline Assessment	34 Participants	39 Participants

SECONDARY outcome

Timeframe: 6 month follow-up

Percentage of participants that self-reported use of any drug in last 12 months at the 6-month assessment. Any of the drugs in the list of substances specified in the NIDA-Modified ASSIST questionnaire.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants That Self-reported Use of Any Drug in Last 12 Months at 6 Month Assessment	32 Participants	28 Participants

SECONDARY outcome

Timeframe: baseline

Percentage of participants that self-reported use of alcohol in the last 12 months at the baseline assessment.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants That Self-reported Use of Alcohol in Last 12 Months at Baseline	31 Participants	35 Participants

SECONDARY outcome

Timeframe: 6-month follow-up

Percentage of participants that self-reported use of alcohol in the last 12 months at the 6-month assessment.

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants That Self-reported Use of Alcohol in Last 12 Months at the 6-month Assessment	29 Participants	26 Participants

SECONDARY outcome

Timeframe: baseline

Percentage of participants with a positive urine test for any drug at the baseline assessment

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants With a Positive Urine Test for Any Drug at Baseline	15 Participants	24 Participants

SECONDARY outcome

Timeframe: 6 month follow-up

Percentage of participants with a positive urine test for any drug at the 6-month assessment

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants With a Positive Urine Test for Any Drug at the 6-month Assessment	11 Participants	15 Participants

SECONDARY outcome

Timeframe: baseline

Percentage of participants with a positive urine test for alcohol at the baseline assessment

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=46 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=49 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants With a Positive Urine Test for Alcohol at the Baseline Assessment	8 Participants	20 Participants

SECONDARY outcome

Timeframe: 6 months

Percentage of participants with a positive urine test for alcohol at the 6-month assessment

Outcome measures

Measure	Alcohol and Drug Use Risk Reduction Arm n=44 Participants Participants in the ADURR condition participated in four Alcohol and drug use risk reduction (ADURR) sessions focused on identifying and making decisions that align with values, managing individual risk-taking behaviors and peer pressure, strengthening interpersonal relationships, and goal setting.	Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm n=46 Participants In addition to the adapted ADU training module that the ADURR-only group will receive, AYLHIV in the intervention arm will receive four (4) Financial Literacy Training (FLT) sessions and a Youth Development Savings account (YDA) for long-term savings. For the proposed study, the EE intervention will be in the form of a YDA, where savings are housed at a local bank and deposits made by the adolescent are matched by the intervention to encourage savings. Each AYLHIV in the EE intervention will receive a YDA held in their own name in a bank registered by the Central Bank (Bank of Uganda). We will form partnerships with national banks operating in the study area. The account will then be matched with money from the program. The maximum adolescent's contribution to be matched by the program will be an equivalent of US $20 per month per adolescent or US $120 for the 6-month intervention period.
Percentage of Participants With a Positive Urine Test for Alcohol at the 6-month Assessment	8 Participants	12 Participants

Adverse Events

Alcohol and Drug Use Risk Reduction Arm

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Alcohol and Drug Use Risk Reduction + Economic Empowerment (ADURR+EE) Arm

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Rachel Brathwaite

Washington University in St. Louis

Phone: 3147282869

Email: rachel.brathwaite@yahoo.com

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place