Trial Outcomes & Findings for HIV-Related Stigma Intervention for Malaysian Clinicians (NCT NCT05597787)
NCT ID: NCT05597787
Last Updated: 2024-12-11
Results Overview
Measured with Acceptability of Intervention Measure. Theoretical or possible range of scores is 1-5, and actual range was 3.50-5. Higher scores indicate greater acceptability.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
78 participants
Primary outcome timeframe
Month 9 Assessment
Results posted on
2024-12-11
Participant Flow
Advertisements were posted to Malaysian medical groups (i.e., Family Medicine Association, Malaysian Medicine Association, Malaysian Primary Care Network, Doctors Only Bulletin Board System) between May and July 2022.
n=411 individuals accessed the registration link. Of these, n=257 were excluded because they declined to participate in the study, were withdrawn because they provided incomplete registration data or their identity could not be verified, or were waitlisted. Of the remaining individuals, n=26 were allocated to an intervention condition. Individuals who did not receive an intervention withdrew, became non-responsive to communication from the project coordinator, or were waitlisted.
Participant milestones
| Measure |
HIV Connect
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
Overall Study
STARTED
|
26
|
26
|
26
|
|
Overall Study
COMPLETED
|
26
|
26
|
25
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
1
|
Reasons for withdrawal
| Measure |
HIV Connect
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
Overall Study
Withdrawal by Subject
|
0
|
0
|
1
|
Baseline Characteristics
HIV-Related Stigma Intervention for Malaysian Clinicians
Baseline characteristics by cohort
| Measure |
HIV Connect
n=26 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=26 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=26 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
Total
n=78 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Continuous
|
37.42 years
STANDARD_DEVIATION 6.37 • n=5 Participants
|
36.50 years
STANDARD_DEVIATION 4.05 • n=7 Participants
|
38.23 years
STANDARD_DEVIATION 7.28 • n=5 Participants
|
37.38 years
STANDARD_DEVIATION 6.02 • n=4 Participants
|
|
Sex: Female, Male
Female
|
13 Participants
n=5 Participants
|
9 Participants
n=7 Participants
|
10 Participants
n=5 Participants
|
32 Participants
n=4 Participants
|
|
Sex: Female, Male
Male
|
13 Participants
n=5 Participants
|
17 Participants
n=7 Participants
|
16 Participants
n=5 Participants
|
46 Participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Malay
|
4 Participants
n=5 Participants
|
14 Participants
n=7 Participants
|
10 Participants
n=5 Participants
|
28 Participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Chinese
|
16 Participants
n=5 Participants
|
6 Participants
n=7 Participants
|
13 Participants
n=5 Participants
|
35 Participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Indian
|
5 Participants
n=5 Participants
|
6 Participants
n=7 Participants
|
13 Participants
n=5 Participants
|
24 Participants
n=4 Participants
|
|
Race/Ethnicity, Customized
Other
|
1 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
1 Participants
n=4 Participants
|
|
Region of Enrollment
Malaysia
|
26 participants
n=5 Participants
|
26 participants
n=7 Participants
|
26 participants
n=5 Participants
|
78 participants
n=4 Participants
|
PRIMARY outcome
Timeframe: Month 9 AssessmentPopulation: Two participants in the Project ECHO for HIV Prevention Condition did not complete the month 9 survey
Measured with Acceptability of Intervention Measure. Theoretical or possible range of scores is 1-5, and actual range was 3.50-5. Higher scores indicate greater acceptability.
Outcome measures
| Measure |
HIV Connect
n=26 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=24 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=26 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
Acceptability of Intervention
|
4.22 score on a scale
Standard Deviation 0.44
|
4.72 score on a scale
Standard Deviation 0.39
|
4.45 score on a scale
Standard Deviation 0.48
|
PRIMARY outcome
Timeframe: Month 9 AssessmentPopulation: Two participants in the Project ECHO for HIV Prevention Condition did not complete the final survey.
Measured with Feasibility of Intervention Measure. Theoretical or possible range of scores is 1-5, and actual range was 3.25-5. Higher scores indicate greater feasibility.
Outcome measures
| Measure |
HIV Connect
n=26 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=24 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=26 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
Feasibility of Intervention
|
4.22 score on a scale
Standard Deviation 0.44
|
4.62 score on a scale
Standard Deviation 0.45
|
4.32 score on a scale
Standard Deviation 0.60
|
PRIMARY outcome
Timeframe: Month 9 AssessmentPopulation: Two participants in the Project ECHO for HIV Prevention condition did not complete the final survey.
Measured with Feelings Thermometers. Positive/Negative affect is measured on 0-100 point scale, with higher scores indicating more prejudice.
Outcome measures
| Measure |
HIV Connect
n=26 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=24 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=26 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
Stigma Reduction: Prejudice
|
29.13 score on a scale
Standard Deviation 18.84
|
23.28 score on a scale
Standard Deviation 20.50
|
32.07 score on a scale
Standard Deviation 15.36
|
PRIMARY outcome
Timeframe: Month 9 AssessmentPopulation: Two participants in the Project ECHO for HIV Prevention condition did not complete the final survey.
Measured with subscale of Multidimensional HIV-Related Stigma Scale. Theoretical or possible range of scores is 1-5, and actual range was 1-3.44. Higher scores indicate greater stereotypes.
Outcome measures
| Measure |
HIV Connect
n=26 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=24 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=26 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
Stigma Reduction: Stereotypes
|
2.55 score on a scale
Standard Deviation 0.50
|
2.01 score on a scale
Standard Deviation 0.59
|
2.32 score on a scale
Standard Deviation 0.69
|
PRIMARY outcome
Timeframe: Month 9 AssessmentPopulation: Two participants in the Project ECHO for HIV Prevention condition did not complete the final survey.
Measured with subscale of Multidimensional HIV-Related Stigma Scale. Theoretical or possible range of scores is 1-5, and actual range was 1-5. Higher scores indicate greater discrimination.
Outcome measures
| Measure |
HIV Connect
n=26 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=24 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=26 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
Stigma Reduction: Discrimination
|
4.44 score on a scale
Standard Deviation 0.50
|
4.67 score on a scale
Standard Deviation 0.85
|
4.64 score on a scale
Standard Deviation 0.42
|
SECONDARY outcome
Timeframe: Cumulative over 9 month interventionPopulation: Submission of procedures data was inconsistent, with many participants missing submissions in each condition.
Measured with weekly diary of HIV tests performed. Number of HIV tests will be summed over duration of intervention.
Outcome measures
| Measure |
HIV Connect
n=19 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=15 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=18 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
HIV Prevention Procedures: HIV Testing
|
21.54 number of HIV tests
Standard Deviation 45.14
|
2.65 number of HIV tests
Standard Deviation 6.17
|
10.46 number of HIV tests
Standard Deviation 46.24
|
SECONDARY outcome
Timeframe: Cumulative over 9 month interventionPopulation: Submission of procedures data was inconsistent, with many participants missing submissions in each condition.
Measured with weekly diary of PrEP prescriptions. Number of PrEP prescriptions will be summed over duration of intervention.
Outcome measures
| Measure |
HIV Connect
n=19 Participants
Participants randomized to this condition will complete HIV Connect, which is an online course developed by the Malaysian Society of HIV Medicine designed to educate primary care physicians in Malaysia about HIV. It consists of a series of modules featuring HIV infectious disease experts who instruct on topics including epidemiology and natural history of HIV, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), sexual history taking and STI testing, and others.
HIV Connect: online education and clinical skills
|
Project ECHO for HIV Prevention
n=15 Participants
Participants randomized to this condition will receive Project ECHO for HIV Prevention, without added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention: education and clinical skills
|
Project ECHO for HIV Prevention + Stigma Reduction
n=18 Participants
Participants randomized to this condition will receive the Project ECHO for HIV Prevention intervention with added evidence-based stigma reduction tools. Participants will meet with the Project ECHO Hub specialists and their learning community on a bi-weekly basis for 60 minutes over the course of 9 months. Each session will feature a didactic training incorporating standardized procedures for HIV testing, prevention, and/or linkage to care, and patient-case presentation and discussion.
Project ECHO for HIV Prevention and Stigma Reduction: education, clinical skills and contact
|
|---|---|---|---|
|
HIV Prevention Procedures: PrEP Prescriptions
|
2.04 number of PrEP prescriptions
Standard Deviation 8.80
|
0.07 number of PrEP prescriptions
Standard Deviation 0.27
|
0.11 number of PrEP prescriptions
Standard Deviation 0.43
|
Adverse Events
HIV Connect
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Project ECHO for HIV Prevention
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Project ECHO for HIV Prevention + Stigma Reduction
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place