Social Information Processing in Children: an ocUlo-pupillometric Tool for Standard Evaluation

NCT ID: NCT05596331

Last Updated: 2023-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

460 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-03

Study Completion Date

2026-09-30

Brief Summary

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The goal of this observational study is to identify behavioral and physiological markers of social alterations in Autism Spectrum Disorders compared to Typically Developping peers. This single-centre study plan to use eye tracking to evaluate social disorders in Autism Spectrum Disorders (ASD). The investigators will estimate oculometric and pupillometric indices as potential ASD biomarkers. The study will last 4 years and will be organized in two phases.

Detailed Description

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In a first phase (expected to last 12-16 months), after an experimental validation in typical adults, relevant oculometric and pupillometric indices will be identified in a typical population of children and in a clinically diagnosed population of ASD children.

In a second phase of the protocol (expected to last 32-36 months), biomarkers identified in the first phase will be tested on a larger population including other neurodevelopmental disorders.

Conditions

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Autism Spectrum Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Group of adult subjects without ASD (Autism Spectrum Disorders)

Age between 18 and 50 years

Group Type OTHER

eye-tracker

Intervention Type OTHER

Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity

Group of children without ASD

Age between 2 and 12 years

Group Type OTHER

eye-tracker

Intervention Type OTHER

Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity

Group of children with ASD

Age between 2 and 12 years Conformity with the diagnostic criteria of ASD according to DSM-V, ICD-10 or ICD-11

Group Type OTHER

eye-tracker

Intervention Type OTHER

Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity

Group of children without NDD (NeuroDevelopmental Disorders)

Age between 0 and 12 years

Group Type OTHER

eye-tracker

Intervention Type OTHER

Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity

Group of children with NDD, or whose diagnosis is in progress

Conformity to the diagnostic criteria of NDD

Group Type OTHER

eye-tracker

Intervention Type OTHER

Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity

Interventions

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eye-tracker

Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Phase 1

All groups have these 2 criteria in common:

Free, informed and signed consent of both parents Enrolment in the social security system

The other criteria per group are as follows:

Group of adult subjects without ASD : Age between 18 and 50 years Group of children without ASD

* Age between 2 and 12 years
* Group of children with ASD Age between 2 and 12 years Conformity with the diagnostic criteria of ASD according to DSM-V, ICD-10 or ICD-11

Phase 2

* Group of children without TND : Age between 0 and 12 years
* Group of children with TND, or whose diagnosis is in progress (via PCO referral) :

Age between 0 and 12 years Conformity to the diagnostic criteria of TND

Exclusion Criteria

Phase 1:


And they have these criteria per group:

* Group of adult subjects without ASD: Subject under guardianship or trusteeship Diagnosis of ASD Group of children without ASD : Diagnosis of ASD
* Group of children with ASD ICD-10 diagnosis of PDD (Rett syndrome and Hayler syndrome) Phase 2
* Group of children without ASD : Diagnosis of ASD (confirmed or ongoing)
Minimum Eligible Age

1 Day

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

UNKNOWN

Sponsor Role collaborator

Laboratory of Fundamental and Applied Computer Science of Tours, EA6300

UNKNOWN

Sponsor Role collaborator

National Research Agency, France

OTHER

Sponsor Role collaborator

Ministry of Health, France

OTHER_GOV

Sponsor Role collaborator

University Hospital, Tours

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nadia Aguillon-Hernandez, MCU

Role: PRINCIPAL_INVESTIGATOR

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Locations

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Service de Pédopsychiatrie-CHU-TOURS

Tours, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Nadia Aguillon-Hernandez, MCU

Role: CONTACT

Phone: 0247478840

Email: [email protected]

Yosra DRIDI

Role: CONTACT

Phone: +33247479792

Email: [email protected]

Facility Contacts

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Nadia AGUILLON-HERNANDEZ, PhD

Role: primary

Other Identifiers

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2022-A00870-43

Identifier Type: REGISTRY

Identifier Source: secondary_id

DR220031/SIRCUS

Identifier Type: -

Identifier Source: org_study_id