A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

NCT ID: NCT05578976

Last Updated: 2025-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

900 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-08

Study Completion Date

2029-12-31

Brief Summary

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B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of this study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP in adult participants globally with diffuse large b-cell lymphoma (DLBCL). Change in disease activity will be assessed.

Epcoritamab is an investigational drug being developed for the treatment of DLBCL. Study doctors put the participants in groups called treatment arms. Participants will receive epcoritamab combined with R-CHOP, followed by epcoritamab or R-CHOP followed by rituximab will be explored. Approximately 900 adult participants with with newly diagnosed DLBCL will be enrolled in the study in approximately 315 sites in globally.

In the Arm 1, participants will receive subcutaneous epcoritamab combined with intravenous and oral R-CHOP followed by subcutaneous epcoritamab in 21-day cycles. In the Arm 2, participants will receive intravenous and oral R-CHOP followed by intravenous rituximab in 21-day cycles.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.

Detailed Description

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Conditions

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Diffuse Large B-Cell Lymphoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Epcoritamab and R-CHOP

Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.

Group Type EXPERIMENTAL

Epcoritamab

Intervention Type DRUG

Subcutaneous Injection (SC)

Cyclophosphamide

Intervention Type DRUG

Intravenous (IV) Injection

Rituximab

Intervention Type DRUG

IV Infusion

Vincristine

Intervention Type DRUG

IV Infusion

Doxorubicin

Intervention Type DRUG

IV Infusion

Prednisone

Intervention Type DRUG

Oral; Tablet

R-CHOP and Rituximab

Participants will receive intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by intravenous rituximab in 21-day cycles.

Group Type EXPERIMENTAL

Cyclophosphamide

Intervention Type DRUG

Intravenous (IV) Injection

Rituximab

Intervention Type DRUG

IV Infusion

Vincristine

Intervention Type DRUG

IV Infusion

Doxorubicin

Intervention Type DRUG

IV Infusion

Prednisone

Intervention Type DRUG

Oral; Tablet

Interventions

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Epcoritamab

Subcutaneous Injection (SC)

Intervention Type DRUG

Cyclophosphamide

Intravenous (IV) Injection

Intervention Type DRUG

Rituximab

IV Infusion

Intervention Type DRUG

Vincristine

IV Infusion

Intervention Type DRUG

Doxorubicin

IV Infusion

Intervention Type DRUG

Prednisone

Oral; Tablet

Intervention Type DRUG

Other Intervention Names

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ABBV-GMAB-3013

Eligibility Criteria

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Inclusion Criteria

* Planned to receive treatment with 6 cycles of standard rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) per investigator determination.
* Must have newly diagnosed, histologically confirmed CD20+ diffuse large b-cell lymphoma \[DLBCL\] (de novo or histologically transformed from a diagnosis of follicular lymphoma) at most recent representative tumor biopsy based on the pathology report, with a World Health Organization (WHO) 2016 classification and including:

* DLBCL, Not Otherwise Specified (NOS).
* High grade B-cell lymphoma with MYC and BCL-2 and/or BCL-6 rearrangement with DLBCL morphology.
* T-cell/histiocyte-rich large B-cell lymphoma.
* Epstein Barr virus-positive DLBCL, NOS.
* Follicular lymphoma Grade 3b.

Note: The local pathology report must be available at Screening to support CD20+ DLBCL histology.

Composite/intermediate histology with any of the following components is not allowed: high grade B-cell lymphoma, NOS; Hodgkin's lymphoma; primary mediastinal (thymic) large B-cell lymphoma; Burkitt; plasmablastic lymphoma or any CD20- lymphoma, such as anaplastic lymphoma kinase-positive large B-cell lymphoma, human herpesvirus type 8-positive DLBCL, or primary effusion lymphoma.

* Availability of archival or fresh or paraffin embedded tissue at Screening.
* Must have an IPI score of 2-5. The number of participants with IPI 2 will not exceed approximately 30% of the overall sample size.
* Must have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 prior to initiating R-CHOP treatment. Note that participant with an initial ECOG performance status \>= 3 may be screened if pre-phase treatment is planned. Participant may be eligible if ECOG performance status were to improve to 0-2 during pre-phase treatment.
* Has at least one target lesion defined as:

* \>= 1 measurable nodal lesion (long axis \> 1.5 cm ) or \>= 1 measurable extra-nodal lesion (long axis \> 1 cm) on computed tomography (CT) scan or magnetic resonance imaging (MRI). AND
* Positron emission tomography (PET)-positive on PET-CT scan.
* Laboratory values meeting the criteria laid out in the protocol.
* Left ventricular ejection fraction must be \>= 50% by multi-gated acquisition or transthoracic echocardiography at Screening.

Exclusion Criteria

* History of prior systemic anti-lymphoma therapy for diagnosed diffuse large b-cell lymphoma (DLBCL) including any definitive radiotherapy with curative intent\] other than corticosteroids with or without vincristine during prephase treatment, or non-curative intent palliative radiotherapy with the stipulation that radiated lesions cannot be selected as target lesion for response assessment.
* Clinically significant cardiovascular disease as per the protocol.
Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Genmab

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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University of Arizona Cancer Center - North Campus /ID# 227463

Tucson, Arizona, United States

Site Status

Yuma Regional Medical Center /ID# 261527

Yuma, Arizona, United States

Site Status

University of Arkansas for Medical Sciences /ID# 225703

Little Rock, Arkansas, United States

Site Status

CBCC Global Research, Inc. /ID# 262037

Bakersfield, California, United States

Site Status

Alta Bates Summit Medical Center for Research /ID# 229427

Berkeley, California, United States

Site Status

Orange Coast Memorial Medical Center /ID# 229632

Fountain Valley, California, United States

Site Status

Providence - St. Jude Medical Center /ID# 262042

Fullerton, California, United States

Site Status

Saddleback Memorial Medical Center /ID# 229631

Laguna Hills, California, United States

Site Status

Long Beach Memorial Medical Ct /ID# 228996

Long Beach, California, United States

Site Status

Cancer and Blood Speciality Clinic - Los Alamitos /ID# 262032

Los Alamitos, California, United States

Site Status

University of Southern California /ID# 225443

Los Angeles, California, United States

Site Status

University of California, Los Angeles /ID# 226887

Los Angeles, California, United States

Site Status

Kaiser Permanente, Waterpark III Institute for Health Research /ID# 228618

Aurora, Colorado, United States

Site Status

Cancer Specialists of North Florida /ID# 226826

Jacksonville, Florida, United States

Site Status

Ocala Oncology Florida Cancer Affiliates - Main /ID# 262785

Ocala, Florida, United States

Site Status

Orlando Health Cancer Institute /ID# 232626

Orlando, Florida, United States

Site Status

Straub Medical Center /ID# 229464

Honolulu, Hawaii, United States

Site Status

University of Illinois at Chicago /ID# 226889

Chicago, Illinois, United States

Site Status

Southern IL Univ School of Med /ID# 228999

Springfield, Illinois, United States

Site Status

Springfield Clinic Main Campus /ID# 262584

Springfield, Illinois, United States

Site Status

Carle Cancer Institute /ID# 228338

Urbana, Illinois, United States

Site Status

Parkview Comprehensive Cancer Center /ID# 227026

Fort Wayne, Indiana, United States

Site Status

Goshen Center for Cancer Care /ID# 225534

Goshen, Indiana, United States

Site Status

University of Iowa Health Care /ID# 261945

Des Moines, Iowa, United States

Site Status

Cancer Center of Kansas /ID# 261983

Wichita, Kansas, United States

Site Status

Norton Cancer Institute - St. Matthews /ID# 225420

Louisville, Kentucky, United States

Site Status

University of Maryland, Baltimore /ID# 225421

Baltimore, Maryland, United States

Site Status

Johns Hopkins Hospital /ID# 225369

Baltimore, Maryland, United States

Site Status

American Oncology Partners of Maryland /ID# 226859

Bethesda, Maryland, United States

Site Status

UMass Memorial Medical Center /ID# 226939

Worcester, Massachusetts, United States

Site Status

University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 225462

Ann Arbor, Michigan, United States

Site Status

Trinity Health St. Joseph Mercy Ann Arbor /ID# 228206

Ypsilanti, Michigan, United States

Site Status

Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 226680

Saint Louis Park, Minnesota, United States

Site Status

University of Mississippi Medical Center /ID# 228045

Jackson, Mississippi, United States

Site Status

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 259014

Billings, Montana, United States

Site Status

NHO Revive Research Institute, LLC /ID# 261113

Lincoln, Nebraska, United States

Site Status

MDACC Cooper /ID# 260320

Camden, New Jersey, United States

Site Status

Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 226654

East Brunswick, New Jersey, United States

Site Status

Morristown Medical Center /ID# 239457

Morristown, New Jersey, United States

Site Status

University of New Mexico /ID# 227332

Albuquerque, New Mexico, United States

Site Status

Presbyterian Kaseman Hospital /ID# 262084

Albuquerque, New Mexico, United States

Site Status

Presbyterian Rust Medical Center /ID# 262068

Rio Rancho, New Mexico, United States

Site Status

Roswell Park Cancer Institute /ID# 239127

Buffalo, New York, United States

Site Status

NYU Langone Hospital - Long Island /ID# 262412

Mineola, New York, United States

Site Status

New York Cancer and Blood Specialists- New Hyde Park /ID# 265392

New Hyde Park, New York, United States

Site Status

NYU Langone - Laura and Isaac Perlmutter Cancer Center /ID# 226141

New York, New York, United States

Site Status

New York Cancer and Blood Specialists- Manhattan /ID# 265391

New York, New York, United States

Site Status

Icahn School of Medicine at Mount Sinai /ID# 225370

New York, New York, United States

Site Status

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 225379

New York, New York, United States

Site Status

New York Cancer and Blood Specialists /ID# 261114

Port Jefferson Station, New York, United States

Site Status

New York Cancer and Blood Specialists- Eastchester, Bronx /ID# 265396

The Bronx, New York, United States

Site Status

Novant Health Presbyterian Medical Center /ID# 227753

Charlotte, North Carolina, United States

Site Status

East Carolina University - Brody School of Medicine /ID# 225992

Greenville, North Carolina, United States

Site Status

Novant Health Forsyth Medical Center /ID# 228339

Winston-Salem, North Carolina, United States

Site Status

University of Cincinnati /ID# 225374

Cincinnati, Ohio, United States

Site Status

OhioHealth Arthur G.H. Bing, MD Cancer Center /ID# 260790

Columbus, Ohio, United States

Site Status

University of Oklahoma, Stephenson Cancer Center /ID# 225556

Oklahoma City, Oklahoma, United States

Site Status

Kaiser Permanente - Northwest /ID# 225488

Portland, Oregon, United States

Site Status

Houston Methodist Hospital /ID# 258957

Houston, Texas, United States

Site Status

Millennium Research & Clinical Development /ID# 228284

Kingwood, Texas, United States

Site Status

Joe Arrington Cancer Research /ID# 227217

Lubbock, Texas, United States

Site Status

Baylor Scott & White Medical Center- Temple /ID# 225935

Temple, Texas, United States

Site Status

Intermountain Medical Center /ID# 231184

Murray, Utah, United States

Site Status

University of Virginia Cancer Center - West Complex /ID# 225433

Charlottesville, Virginia, United States

Site Status

Virginia Commonwealth University Medical Center Main Hospital /ID# 225796

Richmond, Virginia, United States

Site Status

Vista Oncology - East Olympia /ID# 229375

Olympia, Washington, United States

Site Status

MultiCare Institute for Research & Innovation /ID# 225432

Tacoma, Washington, United States

Site Status

MultiCare Regional Cancer Center - Tacoma /ID# 265285

Tacoma, Washington, United States

Site Status

Liverpool Hospital /ID# 230072

Liverpool, New South Wales, Australia

Site Status

Royal Adelaide Hospital /ID# 225683

Adelaide, South Australia, Australia

Site Status

Monash Health - Monash Medical Centre /ID# 225680

Clayton, Victoria, Australia

Site Status

Austin Health /ID# 225716

Heidelberg, Victoria, Australia

Site Status

The Alfred Hospital /ID# 225999

Melbourne, Victoria, Australia

Site Status

Hollywood Private Hospital /ID# 251837

Nedlands, Western Australia, Australia

Site Status

Perth Blood Institute Ltd /ID# 225679

Nedlands, Western Australia, Australia

Site Status

Royal Perth Hospital /ID# 226583

Perth, Western Australia, Australia

Site Status

Universitaetsklinikum St. Poelten /ID# 234016

Sankt Pölten, Lower Austria, Austria

Site Status

Medizinische Universitaet Wien /ID# 252095

Vienna, Vienna, Austria

Site Status

Klinik Ottakring /ID# 243941

Vienna, Vienna, Austria

Site Status

Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 228360

Salzburg, , Austria

Site Status

Duplicate_ZAS Middelheim /ID# 225741

Antwerp, Antwerpen, Belgium

Site Status

ZAS Cadix /ID# 264327

Antwerp, Antwerpen, Belgium

Site Status

Cliniques Universitaires UCL Saint-Luc /ID# 225737

Woluwe-Saint-Lambert, Brussels Capital, Belgium

Site Status

Hospital La Louviere Site Jolimont - Helora /ID# 225738

La Louvière, Hainaut, Belgium

Site Status

CHU de Liège /ID# 225952

Liège, Liege, Belgium

Site Status

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 225742

Yvoir, Namur, Belgium

Site Status

UZ Gent /ID# 250031

Ghent, Oost-Vlaanderen, Belgium

Site Status

Vitaz /Id# 226153

Sint-Niklaas, Oost-Vlaanderen, Belgium

Site Status

Universitair Ziekenhuis Leuven /ID# 225951

Leuven, Vlaams-Brabant, Belgium

Site Status

AZ-Delta /ID# 225736

Roeselare, West-Vlaanderen, Belgium

Site Status

Institut Jules Bordet /ID# 225954

Anderlecht, , Belgium

Site Status

AZ Sint-Jan Brugge /ID# 225735

Bruges, , Belgium

Site Status

Hospital de Clinicas da Universidade Federal do Parana /ID# 226027

Curitiba, Paraná, Brazil

Site Status

Hospital Erasto Gaertner /ID# 262593

Curitiba, Puerto Rico, Brazil

Site Status

Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 226065

Jaú, São Paulo, Brazil

Site Status

Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 226809

São Paulo, São Paulo, Brazil

Site Status

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein /ID# 252832

São Paulo, São Paulo, Brazil

Site Status

Instituto Nacional de Cancer (INCA) /ID# 226026

Rio de Janeiro, , Brazil

Site Status

Real e Benemérita Associação Portuguesa de Beneficência /ID# 226023

São Paulo, , Brazil

Site Status

Hospital Alemao Oswaldo Cruz /ID# 252833

São Paulo, , Brazil

Site Status

Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 262394

São Paulo, , Brazil

Site Status

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 226048

São Paulo, , Brazil

Site Status

UMHAT Sveti Georgi /ID# 245780

Plovdiv, , Bulgaria

Site Status

Acibadem City Clinic Tokuda University Hospital EAD /ID# 244616

Sofia, , Bulgaria

Site Status

UMHAT Sveti Ivan Rilski /ID# 244615

Sofia, , Bulgaria

Site Status

SHAT Hematologic Diseases /ID# 250102

Sofia, , Bulgaria

Site Status

Arthur J.E. Child Comprehensive Cancer Centre Pharmacy /ID# 226077

Calgary, Alberta, Canada

Site Status

BC Cancer - Vancouver /ID# 230573

Vancouver, British Columbia, Canada

Site Status

William Osler Health System /ID# 250973

Brampton, Ontario, Canada

Site Status

Juravinski Cancer Centre /ID# 226084

Hamilton, Ontario, Canada

Site Status

Saskatoon Cancer Centre /ID# 226082

Saskatoon, Saskatchewan, Canada

Site Status

The Fifth Medical Center of PLA General Hospital /ID# 230941

Beijing, Beijing Municipality, China

Site Status

Beijing Cancer Hospital /ID# 229819

Beijing, Beijing Municipality, China

Site Status

Peking University Third Hospital /ID# 230975

Beijing, Beijing Municipality, China

Site Status

Fujian Provincial Cancer Hospital /ID# 238430

Fuzhou, Fujian, China

Site Status

The First Affiliated Hospital of Xiamen University /ID# 238426

Xiamen, Fujian, China

Site Status

Sun Yat-Sen University Cancer Center /ID# 238371

Guangzhou, Guangdong, China

Site Status

Guangdong Provincial People's Hospital /ID# 230945

Guangzhou, Guangdong, China

Site Status

Nanfang Hospital of Southern Medical University /ID# 238436

Guangzhou, Guangdong, China

Site Status

Fourth Hospital of Hebei Medical University /ID# 238656

Shijiazhuang, Hebei, China

Site Status

Harbin Medical University Cancer Hospital /Id# 241755

Harbin, Heilongjiang, China

Site Status

Henan Cancer Hospital /ID# 230398

Zhengzhou, Henan, China

Site Status

Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234152

Wuhan, Hubei, China

Site Status

Hubei Cancer Hospital /ID# 232256

Wuhan, Hubei, China

Site Status

The First Affiliated Hospital of Soochow University /ID# 232569

Suzhou, Jiangsu, China

Site Status

The Affiliated Hospital of Xuzhou Medical College /ID# 233174

Xuzhou, Jiangsu, China

Site Status

The First Affiliated Hospital of Nanchang University /ID# 230399

Nanchang, Jiangxi, China

Site Status

Jiangxi Provincial Cancer Hospital /ID# 233379

Nanchang, Jiangxi, China

Site Status

The First Hospital of Jilin University /ID# 239618

Changchun, Jilin, China

Site Status

The First Hospital of China Medical University /ID# 233201

Shenyang, Liaoning, China

Site Status

Shandong Cancer Hospital /ID# 233200

Jinan, Shandong, China

Site Status

Fudan University Cancer Hospital /ID# 251516

Shanghai, Shanghai Municipality, China

Site Status

Shanxi Provincial Cancer Hospital /ID# 250745

Taiyuan, Shanxi, China

Site Status

Tianjin Cancer Hospital /ID# 230974

Tianjin, Tianjin Municipality, China

Site Status

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 259904

Tianjin, Tianjin Municipality, China

Site Status

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230387

Hangzhou, Zhejiang, China

Site Status

The second affiliated hospital of Zhejiang University school of medicine /ID# 231249

Hangzhou, Zhejiang, China

Site Status

Zhejiang Cancer hospital /ID# 231388

Hangzhou, Zhejiang, China

Site Status

Clinical Hospital Dubrava /ID# 251809

Zagreb, City of Zagreb, Croatia

Site Status

Klinicka bolnica Merkur /ID# 252481

Zagreb, City of Zagreb, Croatia

Site Status

Klinicki bolnicki centar Zagreb /ID# 250709

Zagreb, City of Zagreb, Croatia

Site Status

Klinicki bolnicki centar Rijeka /ID# 251811

Rijeka, Primorje-Gorski Kotar County, Croatia

Site Status

Klinicki Bolnicki Centar (KBC) Split /ID# 250729

Split, Split-Dalmatia County, Croatia

Site Status

Opca bolnica Dr. Josip Bencevic /ID# 251812

Slavonski Brod, , Croatia

Site Status

Fakultní Nemocnice Brno - Jihlavská /ID# 225953

Brno, Brno-mesto, Czechia

Site Status

Fakultní nemocnice Hradec Králové - Sokolská /ID# 225955

Hradec Králové, Hradec Kralove, Czechia

Site Status

Fakultni Nemocnice Ostrava /ID# 225957

Ostrava, Ostrava-mesto, Czechia

Site Status

Fakultni nemocnice Kralovske Vinohrady /ID# 225956

Prague, , Czechia

Site Status

Vseobecna fakultni nemocnice v Praze /ID# 225396

Prague, , Czechia

Site Status

Duplicate_Fakultni Nemocnice v Motole /ID# 225958

Prague, , Czechia

Site Status

Rigshospitalet /ID# 226576

Copenhagen Ø, Capital Region, Denmark

Site Status

Aarhus Universitetshospital - Skejby /ID# 226594

Aarhus, Central Jutland, Denmark

Site Status

Roskilde Sygehus /ID# 226597

Roskilde, Region Sjælland, Denmark

Site Status

Odense University Hospital /ID# 226593

Odense, Region Syddanmark, Denmark

Site Status

Sygehus Lillebalt, Vejle /ID# 226592

Vejle, Region Syddanmark, Denmark

Site Status

CHU de Nice - Hôpital Archet 1 /ID# 226127

Nice, Alpes-Maritimes, France

Site Status

CHU Clermont-Ferrand /ID# 229283

Clermont, Auvergne-Rhône-Alpes, France

Site Status

Institut Paoli-Calmettes /ID# 226557

Marseille, Bouches-du-Rhone, France

Site Status

CHU de Rennes - PONTCHAILLOU /ID# 228207

Rennes, Brittany Region, France

Site Status

CHU Dijon /ID# 238345

Dijon, Cote-d Or, France

Site Status

CHU Limoges - Dupuytren 1 /ID# 234235

Limoges, Franche-Comte, France

Site Status

CHU Montpellier - Hopital Saint Eloi /ID# 228191

Montpellier, Herault, France

Site Status

CHU Grenoble - Hopital Michallon /ID# 226128

La Tronche, Isere, France

Site Status

CHRU Nancy - Hopitaux de Brabois /ID# 226102

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

Site Status

CHRU Lille - Hopital Claude Huriez /ID# 226101

Lille, Nord, France

Site Status

Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 226560

Créteil, Paris, France

Site Status

CHU de Nantes, Hotel Dieu -HME /ID# 226125

Nantes, Pays de la Loire Region, France

Site Status

Centre Hospitalier de la Cote Basque /ID# 249143

Bayonne, Pyrenees-Atlantiques, France

Site Status

HCL - Hopital Lyon Sud /ID# 227086

Pierre-Bénite, Rhone, France

Site Status

Centre Henri Becquerel /ID# 226103

Rouen, Seine-Maritime, France

Site Status

CHU Amiens-Picardie Site Sud /ID# 238347

Amiens, Somme, France

Site Status

CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 243899

La Roche-sur-Yon, Vendee, France

Site Status

CHU Poitiers - La miletrie /ID# 226578

Poitiers, Vienne, France

Site Status

Chu Angers /Id# 245931

Angers, , France

Site Status

CHU de CAEN - Hopital de la Cote de Nacre /ID# 226582

Caen, , France

Site Status

Hôpital Saint-Louis /ID# 226126

Paris, , France

Site Status

Institut Curie - site CLCC René Huguenin /ID# 253519

Saint-Cloud, , France

Site Status

Hopital Pitie Salpetriere /ID# 238343

Paris, Île-de-France Region, France

Site Status

General Hospital of Athens Laiko /ID# 225399

Athens, Attica, Greece

Site Status

Alexandra General Hospital /ID# 225402

Athens, Attica, Greece

Site Status

University General Hospital Attikon /ID# 225401

Athens, Attica, Greece

Site Status

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 225416

Athens, , Greece

Site Status

University General Hospital of Ioannina /ID# 225400

Ioannina, , Greece

Site Status

General University Hospital of Thessaloniki AXEPA /ID# 225398

Thessaloniki, , Greece

Site Status

Theageneio Anticancer Hospital /ID# 225516

Thessaloniki, , Greece

Site Status

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 257189

Győr, Győr-Moson-Sopron, Hungary

Site Status

Debreceni Egyetem-Klinikai Kozpont /ID# 226821

Debrecen, Hajdú-Bihar, Hungary

Site Status

Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 245938

Kaposvár, Somogy County, Hungary

Site Status

Tolna Varmegyei Balassa Janos Korhaz /ID# 250063

Szekszárd, Tolna County, Hungary

Site Status

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 226846

Szombathely, Vas County, Hungary

Site Status

Semmelweis Egyetem /ID# 227239

Budapest, , Hungary

Site Status

Orszagos Onkologiai Intezet /ID# 227294

Budapest, , Hungary

Site Status

Szegedi Tudományegyetem /ID# 226838

Szeged, , Hungary

Site Status

Meir Medical Center /ID# 225612

Kfar Saba, Central District, Israel

Site Status

Assuta Tel Aviv Medical Center /ID# 226066

Tel Aviv, Central District, Israel

Site Status

Rambam Health Care Campus /ID# 225981

Haifa, H_efa, Israel

Site Status

Shaare Zedek Medical Center /ID# 259796

Jerusalem, Jerusalem, Israel

Site Status

Hadassah /ID# 225614

Jerusalem, Jerusalem, Israel

Site Status

The Chaim Sheba Medical Center /ID# 225600

Ramat Gan, Tel Aviv, Israel

Site Status

Tel Aviv Sourasky Medical Center /ID# 225891

Tel Aviv, Tel Aviv, Israel

Site Status

Rabin Medical Center /ID# 225862

Petah Tikva, , Israel

Site Status

IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 225551

Bologna, Emilia-Romagna, Italy

Site Status

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 225554

San Giovanni Rotondo, Foggia, Italy

Site Status

IRCCS Ospedale San Raffaele /ID# 225555

Milan, Milano, Italy

Site Status

Istituto Europeo Di Oncologia /ID# 225545

Milan, Milano, Italy

Site Status

Azienda Ospedaliera Universitaria Federico II /ID# 225543

Naples, Napoli, Italy

Site Status

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 225775

Turin, Piedmont, Italy

Site Status

Duplicate_Centro di Riferimento Oncologico /ID# 225553

Aviano, Pordenone, Italy

Site Status

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 252192

Meldola, Reggio Emilia, Italy

Site Status

Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 225751

Candiolo, Torino, Italy

Site Status

Azienda Ospedaliero - Universitaria SS. Antonio e Biagio e Cesare Arrigo - Aless /ID# 225542

Alessandria, , Italy

Site Status

I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 225548

Bari, , Italy

Site Status

Duplicate_ASST Spedali civili di Brescia /ID# 225549

Brescia, , Italy

Site Status

Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 225773

Novara, , Italy

Site Status

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 225541

Palermo, , Italy

Site Status

Azienda Ospedaliero Universitaria Pisana /ID# 225575

Pisa, , Italy

Site Status

Ospedale Santa Maria Delle Croci /ID# 225571

Ravenna, , Italy

Site Status

NHO Nagoya Medical Center /ID# 230677

Nagoya, Aichi-ken, Japan

Site Status

Aichi Cancer Center Hospital /ID# 226090

Nagoya, Aichi-ken, Japan

Site Status

National Cancer Center Hospital East /ID# 250151

Kashiwa-shi, Chiba, Japan

Site Status

Matsuyama Red Cross Hospital /ID# 251068

Matsuyama, Ehime, Japan

Site Status

National Hospital Organization Kyushu Cancer Center /ID# 251622

Fukuoka, Fukuoka, Japan

Site Status

Kyushu University Hospital /ID# 226091

Fukuoka, Fukuoka, Japan

Site Status

Fukushima Medical University Hospital /ID# 250869

Fukushima, Fukushima, Japan

Site Status

Duplicate_Hokkaido University Hospital /ID# 250149

Sapporo, Hokkaido, Japan

Site Status

Kobe City Medical Center General Hospital /ID# 250597

Kobe, Hyōgo, Japan

Site Status

University of Tsukuba Hospital /ID# 251282

Tsukuba, Ibaraki, Japan

Site Status

Kanazawa University Hospital /ID# 251770

Kanazawa, Ishikawa-ken, Japan

Site Status

Kagoshima University Hospital /ID# 250163

Kagoshima, Kagoshima-ken, Japan

Site Status

Tokai University Hospital /ID# 251281

Isehara, Kanagawa, Japan

Site Status

Tohoku University Hospital /ID# 250150

Sendai, Miyagi, Japan

Site Status

Okayama University Hospital /ID# 250161

Okayama, Okayama-ken, Japan

Site Status

Kindai University Hospital /ID# 250160

Osakasayama-shi, Osaka, Japan

Site Status

Osaka University Hospital /ID# 251283

Suita-shi, Osaka, Japan

Site Status

National Cancer Center Hospital /ID# 226089

Chuo-ku, Tokyo, Japan

Site Status

The Cancer Institute Hospital Of JFCR /ID# 230269

Koto-ku, Tokyo, Japan

Site Status

Yamagata University Hospital /ID# 230003

Yamagata, Yamagata, Japan

Site Status

Flevo Ziekenhuis /ID# 229606

Almere Stad, Flevoland, Netherlands

Site Status

Gelre Ziekenhuizen /ID# 229762

Apeldoorn, Gelderland, Netherlands

Site Status

Canisius-Wilhelmina Ziekenhuis /ID# 231291

Nijmegen, Gelderland, Netherlands

Site Status

Maastricht Universitair Medisch Centrum /ID# 225607

Maastricht, Limburg, Netherlands

Site Status

Amphia Ziekenhuis /ID# 229550

Breda, North Brabant, Netherlands

Site Status

Catharina Ziekenhuis /ID# 230465

Eindhoven, North Brabant, Netherlands

Site Status

Maxima Medisch Centrum /ID# 225603

Eindhoven, North Brabant, Netherlands

Site Status

Elisabeth Tweesteden Ziekenhuis /ID# 229773

Tilburg, North Brabant, Netherlands

Site Status

Noordwest Ziekenhuisgroep /ID# 230613

Alkmaar, North Holland, Netherlands

Site Status

Vrije Universiteit Medisch Centrum /ID# 225608

Amsterdam, North Holland, Netherlands

Site Status

Olvg /Id# 229761

Amsterdam, North Holland, Netherlands

Site Status

Spaarne Gasthuis, Haarlem Zuid /ID# 229621

Haarlem, North Holland, Netherlands

Site Status

Tergooi /ID# 229772

Hilversum, North Holland, Netherlands

Site Status

Dijklander Ziekenhuis /ID# 229900

Hoorn, North Holland, Netherlands

Site Status

Zaans Medisch Centrum /ID# 230614

Zaandam, North Holland, Netherlands

Site Status

Medisch Spectrum Twente /ID# 225610

Enschede, Overijssel, Netherlands

Site Status

Medisch Centrum Leeuwarden /ID# 225605

Leeuwarden, Provincie Friesland, Netherlands

Site Status

Albert Schweitzer Ziekenhuis /ID# 229560

Dordrecht, South Holland, Netherlands

Site Status

Leids Universitair Medisch Centrum /ID# 225606

Leiden, South Holland, Netherlands

Site Status

Meander Medisch Centrum /ID# 229608

Amersfoort, Utrecht, Netherlands

Site Status

St. Antonius Ziekenhuis /ID# 229901

Nieuwegein, Utrecht, Netherlands

Site Status

Jeroen Bosch Ziekenhuis /ID# 229765

's-Hertogenbosch, , Netherlands

Site Status

Deventer Ziekenhuis /ID# 229937

Deventer, , Netherlands

Site Status

Universitair Medisch Centrum Groningen /ID# 225602

Groningen, , Netherlands

Site Status

Haaglanden Medisch Centrum /ID# 229686

The Hague, , Netherlands

Site Status

Diakonessenhuis /ID# 251793

Utrecht, , Netherlands

Site Status

North Shore Hospital /ID# 250992

Takapuna, Auckland, New Zealand

Site Status

Christchurch Hospital /ID# 250993

Christchurch, Canterbury, New Zealand

Site Status

ARS-MEDICAL Sp. z o.o. /ID# 225848

Piła, Greater Poland Voivodeship, Poland

Site Status

Centrum Medyczne Pratia Poznan /ID# 227236

Skórzewo, Greater Poland Voivodeship, Poland

Site Status

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka /ID# 228723

Słupsk, Pomeranian Voivodeship, Poland

Site Status

Szpital Kliniczny MSWiA z Warminsko-Mazurskim Centrum Onkologii /ID# 225985

Olsztyn, Warmian-Masurian Voivodeship, Poland

Site Status

Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 225986

Kielce, Świętokrzyskie Voivodeship, Poland

Site Status

2CA-Braga, Hospital de Braga /ID# 249112

Braga, , Portugal

Site Status

IPO Lisboa FG, EPE /ID# 249109

Lisbon, , Portugal

Site Status

Unidade Local de Saude de Santa Maria, EPE /ID# 249111

Lisbon, , Portugal

Site Status

IPO Porto FG, EPE /ID# 249110

Porto, , Portugal

Site Status

Hematology and Oncology Institute /ID# 230054

Manatí, , Puerto Rico

Site Status

Pan American Center for Oncology Trials, LLC /ID# 230052

Rio Piedras, , Puerto Rico

Site Status

Narodny onkologicky ustav /ID# 238847

Bratislava, Bratislava Region, Slovakia

Site Status

Univerzitna nemocnica Martin /ID# 240828

Martin, Žilina Region, Slovakia

Site Status

Wits Clinical Research /ID# 227799

Johannesburg, Gauteng, South Africa

Site Status

Wits Clinical Research /ID# 227803

Johannesburg, Gauteng, South Africa

Site Status

Alberts Cellular Therapy /ID# 227798

Pretoria, Gauteng, South Africa

Site Status

University of Cape Town /ID# 227802

Cape Town, Western Cape, South Africa

Site Status

Haemalife Inc. /ID# 243391

Kuils River, Western Cape, South Africa

Site Status

Inje University - Busan Paik Hospital /ID# 232262

Busan, Busan Gwang Yeogsi, South Korea

Site Status

Seoul National University Bundang Hospital /ID# 225763

Seongnam-si, Gyeonggido, South Korea

Site Status

Keimyung University Dongsan Hospital /ID# 232264

Daegu, Gyeongsangbuk-do, South Korea

Site Status

Dong-A University Medical Center /ID# 228451

Pusan, Gyeongsangnam-do, South Korea

Site Status

Jeonbuk National University Hospital /ID# 232263

Jeonju, Jeonrabugdo, South Korea

Site Status

Seoul National University Hospital /ID# 225760

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Asan Medical Center /ID# 225758

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Samsung Medical Center /ID# 225759

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 225761

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Ulsan University Hospital /ID# 226971

Ulsan, Ulsan Gwang Yeogsi, South Korea

Site Status

Instituto Catalan de Oncologia (ICO) Badalona /ID# 228063

Badalona, Barcelona, Spain

Site Status

Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 227393

L'Hospitalet de Llobregat, Barcelona, Spain

Site Status

Hospital Universitario Reina Sofia /ID# 225806

Córdoba, Cordoba, Spain

Site Status

Hospital Clinico Universitario Virgen de la Arrixaca /ID# 255381

El Palmar, Murcia, Spain

Site Status

Clinica Universidad de Navarra - Pamplona /ID# 225809

Pamplona, Navarre, Spain

Site Status

Hospital Parc de Salut del Mar /ID# 225810

Barcelona, , Spain

Site Status

Hospital Universitario Vall d'Hebron /ID# 225811

Barcelona, , Spain

Site Status

Hospital Clinic de Barcelona /ID# 226651

Barcelona, , Spain

Site Status

Hospital Santa Creu i Sant Pau /ID# 225813

Barcelona, , Spain

Site Status

CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 228228

Madrid, , Spain

Site Status

Hospital Universitario Infanta Leonor /ID# 225816

Madrid, , Spain

Site Status

MD Anderson Madrid /ID# 225817

Madrid, , Spain

Site Status

Hospital Universitario Ramon y Cajal /ID# 241750

Madrid, , Spain

Site Status

Hospital Universitario Fundacion Jimenez Diaz /ID# 225804

Madrid, , Spain

Site Status

Hospital Universitario 12 de Octubre /ID# 225815

Madrid, , Spain

Site Status

Hospital Clinico Universitario de Valencia /ID# 225818

Valencia, , Spain

Site Status

Skane University Hospital Lund /ID# 227285

Lund, Skåne County, Sweden

Site Status

Karolinska University Hospital Solna /ID# 229284

Solna, Stockholm County, Sweden

Site Status

Sodra Alvsborgs sjukhus /ID# 228885

Borås, Västra Götaland County, Sweden

Site Status

Sahlgrenska Universitetssjukhuset /ID# 250089

Gothenburg, Västra Götaland County, Sweden

Site Status

Linkoping University Hospital /ID# 233521

Linköping, Östergötland County, Sweden

Site Status

Kantonsspital Aarau AG /ID# 229112

Aarau, Canton of Aargau, Switzerland

Site Status

Spital Thun /ID# 229499

Thun, Canton of Bern, Switzerland

Site Status

KSW Kantonsspital Winterthur /ID# 241631

Winterthur, Canton of Zurich, Switzerland

Site Status

Kaohsiung Chang Gung Memorial Hospital /ID# 226670

Kaohsiung City, Kaohsiung, Taiwan

Site Status

China Medical University Hospital /ID# 226188

Taichung, , Taiwan

Site Status

Taichung Veterans General Hospital /ID# 226674

Taichung, , Taiwan

Site Status

National Cheng Kung University Hospital /ID# 226671

Tainan City, , Taiwan

Site Status

Anadolu Saglik Merkezi /ID# 225777

Dilovası, Kocaeli, Turkey (Türkiye)

Site Status

Ankara Universitesi Fakultesi /ID# 227331

Ankara, , Turkey (Türkiye)

Site Status

Inonu University Medical Faculty /ID# 226572

Malatya, , Turkey (Türkiye)

Site Status

Ondokuz Mayis Universitesi /ID# 251247

Samsun, , Turkey (Türkiye)

Site Status

Karadeniz University /ID# 226573

Trabzon, , Turkey (Türkiye)

Site Status

Baskent Universitesi Adana Uyg. ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 225921

Yüreğir, , Turkey (Türkiye)

Site Status

Hammersmith Hospital /ID# 242215

London, England, United Kingdom

Site Status

Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 226692

Norwich, Norfolk, United Kingdom

Site Status

University Hospitals Birmingham NHS Foundation Trust /ID# 229197

Birmingham, , United Kingdom

Site Status

NHS Lothian /ID# 229055

Edinburgh, , United Kingdom

Site Status

Countries

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United States Australia Austria Belgium Brazil Bulgaria Canada China Croatia Czechia Denmark France Greece Hungary Israel Italy Japan Netherlands New Zealand Poland Portugal Puerto Rico Slovakia South Africa South Korea Spain Sweden Switzerland Taiwan Turkey (Türkiye) United Kingdom

Related Links

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Other Identifiers

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2023-505277-32

Identifier Type: OTHER

Identifier Source: secondary_id

M20-621

Identifier Type: -

Identifier Source: org_study_id

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