Trial Outcomes & Findings for Efficacy of Movement Breaks in Real-World Settings (NCT NCT05574426)

NCT ID: NCT05574426

Last Updated: 2025-03-21

Results Overview

Cardiorespiratory fitness will be assessed as the highest 30-s average from a laboratory-based graded VO2peak test on a cycle ergometer.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

77 participants

Primary outcome timeframe

Baseline and Week 12

Results posted on

2025-03-21

Participant Flow

Online recruitment primarily through use of third-party service.

77 participants were included in the intention-to-treat analyses

Participant milestones

Participant milestones
Measure	Cardiovascular Movement Breaks Participants were instructed to perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm were designed to increase heart rate.	Mobility Movement Breaks Participants were instructed to perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm were not designed to increase heart rate.
Overall Study STARTED	38	39
Overall Study COMPLETED	34	39
Overall Study NOT COMPLETED	4	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Cardiovascular Movement Breaks n=38 Participants Participants were instructed to perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm were designed to increase heart rate.	Mobility Movement Breaks n=39 Participants Participants were instructed to perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm were not designed to increase heart rate.	Total n=77 Participants Total of all reporting groups
Age, Continuous	54 Years STANDARD_DEVIATION 6 • n=38 Participants	53 Years STANDARD_DEVIATION 7 • n=39 Participants	54 Years STANDARD_DEVIATION 6 • n=77 Participants
Sex: Female, Male Female	27 Participants n=38 Participants	29 Participants n=39 Participants	56 Participants n=77 Participants
Sex: Female, Male Male	11 Participants n=38 Participants	10 Participants n=39 Participants	21 Participants n=77 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
VO2peak	24.4 ml/kg/min STANDARD_DEVIATION 4.3 • n=38 Participants	24.6 ml/kg/min STANDARD_DEVIATION 4.5 • n=39 Participants	24.5 ml/kg/min STANDARD_DEVIATION 4.4 • n=77 Participants

PRIMARY outcome

Timeframe: Baseline and Week 12

Population: Intention-to-treat

Cardiorespiratory fitness will be assessed as the highest 30-s average from a laboratory-based graded VO2peak test on a cycle ergometer.

Outcome measures

Outcome measures
Measure	Cardiovascular Movement Breaks n=38 Participants Participants were instructed to perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm were designed to increase heart rate.	Mobility Movement Breaks n=39 Participants Participants were instructed to perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm were not designed to increase heart rate.
Change From Baseline in Cardiorespiratory Fitness at 12 Weeks	-0.6 ml/kg/min Interval -1.4 to 0.2	-1.0 ml/kg/min Interval -1.7 to -0.3

SECONDARY outcome

Timeframe: Baseline and 12 weeks

Population: Intention-to-treat

A fasted venous blood sample will be obtained and insulin measured by commercial assay.

Outcome measures

Outcome measures
Measure	Cardiovascular Movement Breaks n=38 Participants Participants were instructed to perform 3-4 exercise snacks (30-60s bursts of exercise) on at least 3 days of the week. The exercises prescribed in this arm were designed to increase heart rate.	Mobility Movement Breaks n=39 Participants Participants were instructed to perform 3-4 mobility snacks (30-60s of mobility exercises or stretching) on at least 3 days of the week. The exercises prescribed in this arm were not designed to increase heart rate.
Change From Baseline in Plasma Insulin	-13 percent change Interval -23.0 to -1.0	-2 percent change Interval -13.0 to 10.0

SECONDARY outcome

Timeframe: Baseline and 12 weeks

A fasted venous blood sample will be obtained and glucose measured by biochemical assay.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Baseline and 12 weeks

A fasted venous blood sample will be obtained and insulin resistance estimated by homeostasis model assessment (HOMA) score

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Baseline and 12 weeks

A fasted venous blood sample will be obtained and inflammatory cytokines measured by multiplex assay

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Baseline and 12 weeks

Body mass will be measured by weigh scale

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Baseline and 12 weeks

Waist circumference (in centimetres) will be measured using a measurement tape.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Week 2 and week 11

Participants will wear accelerometers to assess adherence near the beginning and the end of the intervention.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Once per week for 12 weeks

Participants will be sent weekly surveys asking them to recall the total number of movement breaks performed that week.

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Immediately following each movement break for entire 12-week intervention

The EES is a validated, single-item 7-point scale to assess exercise enjoyment. Possible scores range from 1 (not at all) to 7 (extremely).

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: Immediately following each movement break for entire 12-week intervention

A 10 point RPE scale will be used to assess perceived exertion ranging from 0 (rest) to 10 (maximal).

Outcome measures

Outcome data not reported

Adverse Events

Cardiovascular Movement Breaks

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Mobility Movement Breaks

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Jonathan Little

University of British Columbia

Phone: 250-807-9876

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place