A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older

NCT ID: NCT05566639

Last Updated: 2025-01-16

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

22502 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-14

Study Completion Date

2024-01-05

Brief Summary

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The purpose of this study is to evaluate the safety and efficacy of mRNA-1010 in preventing seasonal influenza in adults 50 years and older.

Detailed Description

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Conditions

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Seasonal Influenza

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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mRNA-1010

Participants will receive a single dose of mRNA-1010 by intramuscular (IM) injection on Day 1.

Group Type EXPERIMENTAL

mRNA-1010

Intervention Type BIOLOGICAL

Sterile liquid for injection

Fluarix Quadrivalent

Participants will receive a single dose of Fluarix Quadrivalent by IM injection on Day 1.

Group Type ACTIVE_COMPARATOR

Fluarix Quadrivalent

Intervention Type BIOLOGICAL

Sterile suspension for injection.

Interventions

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mRNA-1010

Sterile liquid for injection

Intervention Type BIOLOGICAL

Fluarix Quadrivalent

Sterile suspension for injection.

Intervention Type BIOLOGICAL

Other Intervention Names

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Seasonal influenza vaccine Licensed quadrivalent inactivated seasonal influenza vaccine

Eligibility Criteria

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Inclusion Criteria

* Investigator has assessed that the participant understands and is willing and physically able to comply with protocol mandated follow-up, including all procedures.

* For female participants of childbearing potential: negative pregnancy test, adequate contraception or has abstained from all activities that could result in pregnancy for at least 28 days prior to the first dose on Day 1, and agreement to continue adequate contraception through 90 days following vaccine administration.

Exclusion Criteria

* Participant has had close contact with someone with laboratory-confirmed influenza infection or with someone who has been treated with antiviral therapies for influenza (for example, Tamiflu®) within the past 5 days prior to the Screening visit.
* Participant has had close contact to someone with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or COVID-19 as defined by the US CDC or has had a positive SARS-CoV-2 test in the past 10 days prior to the Screening visit.
* Participant is acutely ill or febrile (temperature ≥38.0℃elcius \[100.4°Fahrenheit\]) 72 hours prior to or at the Screening visit or Day 1. Participants meeting this criterion may be rescheduled within the 28-day screening window.
* Participant has a history of a diagnosis or condition that, in the judgment of the investigator, is clinically unstable or may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures.
* Reported history of congenital or acquired immunodeficiency, immunocompromising/ immunosuppressive condition, asplenia, or recurrent severe infections.
* Reported history of anaphylaxis or severe hypersensitivity reaction after receipt of any mRNA or influenza vaccines or any components of the mRNA or influenza vaccines, including egg protein.
* Participant has received systemic immunosuppressant drugs for \>14 days in total within 180 days prior to the Screening visit (for glucocorticosteroids, ≥10 milligrams (mg)/day of prednisone or equivalent) or is anticipating the need for systemic immunosuppressive treatment at any time during participation in the study. Inhaled, nasal, and topical steroids are allowed.
* Participant has received any vaccine authorized or approved by local health agency ≤28 days prior to study intervention (Day 1) or plans to receive a vaccine authorized or approved by local health agency within 28 days before or after the study intervention.
* Participant is unaware whether they have received an influenza vaccine in the previous influenza season.
* Participant received a seasonal influenza vaccine or any other investigational influenza vaccine within 180 days prior to Day 1
* Participant has tested positive for influenza by local health authority-approved testing methods within 180 days prior to Day 1.
* Participant has donated ≥450 milliliters (mL) of blood products within 28 days prior to the Screening visit or plans to donate blood products during the study.
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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ModernaTX, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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North Alabama Research Center, LLC

Athens, Alabama, United States

Site Status

Lenzmeier Family Medicine

Glendale, Arizona, United States

Site Status

CCT Research

Phoenix, Arizona, United States

Site Status

Fiel Family and Sports Medicine/CCT Research

Tempe, Arizona, United States

Site Status

Noble Clinical Research

Tucson, Arizona, United States

Site Status

Lynn Institute of the Ozarks

Little Rock, Arkansas, United States

Site Status

Baptist Health Center for Clinical Research

Little Rock, Arkansas, United States

Site Status

Velocity Clinical Research, Banning

Banning, California, United States

Site Status

Hope Clinical Research, LLC

Canoga Park, California, United States

Site Status

Marvel Clinical Research

Huntington Beach, California, United States

Site Status

Velocity Clinical Research, Chula Vista

La Mesa, California, United States

Site Status

Velocity Clinical Research, San Diego

La Mesa, California, United States

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Velocity Clinical Research - Westlake

Los Angeles, California, United States

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Empire Clinical Research

Pomona, California, United States

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Artemis Institute for Clinical Research

Riverside, California, United States

Site Status

Benchmark Research-Texas

Riverside, California, United States

Site Status

Peninsula Research Associates (PRA)

Rolling Hills Estates, California, United States

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Artemis Institute for Clinical Research

San Diego, California, United States

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Women's Health Care Research Corp.

San Diego, California, United States

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Acclaim Clinical Research

San Diego, California, United States

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Medical Center for Clinical Research

San Diego, California, United States

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Shawn K Hassler MD

San Francisco, California, United States

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West Coast Research LLC

San Ramon, California, United States

Site Status

Velocity Clinical Research, Denver

Denver, Colorado, United States

Site Status

Arthritis & Rheumatology - Clinic of Northern Colorado

Fort Collins, Colorado, United States

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Longmont Medical Research Network

Longmont, Colorado, United States

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Nature Coast Clinical Research, LLC - Crystal River

Crystal River, Florida, United States

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Floridian Clinical Research

Hialeah, Florida, United States

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Homestead Associates in Research,Inc

Hialeah, Florida, United States

Site Status

Broward Research Group

Hollywood, Florida, United States

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Citrus Cardiology Consultants

Inverness, Florida, United States

Site Status

Encore Research Group-Jacksonville Center for Clinical Resea

Jacksonville, Florida, United States

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Health Awareness, Inc

Jupiter, Florida, United States

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Multi-Therapeutic Research Associates, Inc.

Lake City, Florida, United States

Site Status

Accel Research Sites - Lakeland

Lakeland, Florida, United States

Site Status

ARS - Meridien Research

Maitland, Florida, United States

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South Florida Research Center, Inc.

Miami, Florida, United States

Site Status

Suncoast Research Associates Trials, LLC

Miami, Florida, United States

Site Status

Miami centre of clinical research

Miami, Florida, United States

Site Status

Clinical Trials of Florida, LLC

Miami, Florida, United States

Site Status

Global Health Research Center

Miami Lakes, Florida, United States

Site Status

Innovation Medical Research Center,inc

Palmetto Bay, Florida, United States

Site Status

New Tampa Health, Inc

Tampa, Florida, United States

Site Status

Tekton Research, Inc.

Chamblee, Georgia, United States

Site Status

Southeast Regional Research Group

Columbus, Georgia, United States

Site Status

iResearch Atlanta, LLC

Decatur, Georgia, United States

Site Status

In-Quest Medical Research

Norcross, Georgia, United States

Site Status

Mount Vernon Clinical Research

Sandy Springs, Georgia, United States

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Meridian Clinical Research - Savannah

Savannah, Georgia, United States

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Clinical Research Atlanta

Stockbridge, Georgia, United States

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Velocity Clinical Research - Boise

Meridian, Idaho, United States

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Great Lakes Clinical Trials LLC

Chicago, Illinois, United States

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Great Lakes Clinical Trials LLC

Chicago, Illinois, United States

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Great Lakes Clinical Trials LLC

Gurnee, Illinois, United States

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Chicago Health Medical Group

River Forest, Illinois, United States

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Velocity Clinical Research - Valparaiso

Valparaiso, Indiana, United States

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Meridian Clinical Research - Dakota Dunes

Sioux City, Iowa, United States

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Johnson County Clin-Trials (JCCT)

Lenexa, Kansas, United States

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Heartland Research Associates LLC

Newton, Kansas, United States

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Alliance for Multispecialty Research

Wichita, Kansas, United States

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Meridian Clinical Research

Baton Rouge, Louisiana, United States

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MedPharmics

Covington, Louisiana, United States

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Medpharmics, LLC

Metairie, Louisiana, United States

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Nathan H Fischman MD LLC

New Orleans, Louisiana, United States

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Privia Medical Group

Annapolis, Maryland, United States

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Rockville Internal Medicine Group

Rockville, Maryland, United States

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Delricht Research

Springfield, Massachusetts, United States

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DM Clinical Research - Detroit

Southfield, Michigan, United States

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Paul G Matherne MD

Biloxi, Mississippi, United States

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DELRICHT RESEARCH at GULFPORT MEMORIAL

Gulfport, Mississippi, United States

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National Medical University and Embryonic Tissues Center EmC

Springfield, Missouri, United States

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Sundance Clinical Research, LLC

St Louis, Missouri, United States

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Montana Medical Research, Inc

Missoula, Montana, United States

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CCT Research at Skyline Medical Center, PC

Elkhorn, Nebraska, United States

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CCT Research / Methodist Physicians Clinic, Prairie Fields Family Medicine, PC

Fremont, Nebraska, United States

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Meridian Clinical Research

Grand Island, Nebraska, United States

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Be Well Clinical Studies, LLC

Lincoln, Nebraska, United States

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Medpace, Inc. - Clinical Pharmacology Unit (CPU)

Norfolk, Nebraska, United States

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Meridian Clinical Research

Norfolk, Nebraska, United States

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Papillon Research Centre

Omaha, Nebraska, United States

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Meridian Clinical Research - Omaha

Omaha, Nebraska, United States

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Midwest Regional Health Services, LLC/CCT Research

Omaha, Nebraska, United States

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CCT Research

Las Vegas, Nevada, United States

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Clinical Research Center of Nevada LLC

Las Vegas, Nevada, United States

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Santa Rosa Medical Centers of Nevada/ CCT Research

Las Vegas, Nevada, United States

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Las Vegas Clinical Trials, LLC

North Las Vegas, Nevada, United States

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United Medical Associates

Binghamton, New York, United States

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Rochester Clinical Research, Inc

Rochester, New York, United States

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Velocity Clinical Research - Syracuse

Syracuse, New York, United States

Site Status

Tryon Medical Group

Charlotte, North Carolina, United States

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Carolina Institute for Clinical Research

Fayetteville, North Carolina, United States

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Diabetes & Endocrinology Consultants

Morehead City, North Carolina, United States

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M3 Wake Research, Inc.

Raleigh, North Carolina, United States

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PMG Research of Wilmington

Wilmington, North Carolina, United States

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Trial Management Associates

Wilmington, North Carolina, United States

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Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States

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Radiant Research

Akron, Ohio, United States

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Sterling Research Group

Cincinnati, Ohio, United States

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CTI Clinical Research Center

Cincinnati, Ohio, United States

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Velocity Clinical Research - Cincinnati

Cincinnati, Ohio, United States

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Lynn Health Science Institute

Oklahoma City, Oklahoma, United States

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Delricht Research Tulsa

Tulsa, Oklahoma, United States

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Platinum Research Network, LLC

Yukon, Oklahoma, United States

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Velocity Clinical Research - Grants Pass

Grants Pass, Oregon, United States

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Velocity Clinical Resarch - Medford

Medford, Oregon, United States

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Velocity Clinical Research - Providence

Warwick, Rhode Island, United States

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Velocity Clinical Research, Greenville

Anderson, South Carolina, United States

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Velocity Clinical Research - Columbia

Columbia, South Carolina, United States

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Velocity Clinical Research, Gaffney

Gaffney, South Carolina, United States

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Velocity Clinical Research - Greenville

Greenville, South Carolina, United States

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Carolina Health Specialists

Myrtle Beach, South Carolina, United States

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Spartanburg Regional Health Services

Spartanburg, South Carolina, United States

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Black Hills Center for American Indian Health

Rapid City, South Dakota, United States

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Delricht Research

Hendersonville, Tennessee, United States

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Tekton Research, Inc

Austin, Texas, United States

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Platinum Research Network, LLC

Beaumont, Texas, United States

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Zenos Clinical Research

Dallas, Texas, United States

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Benchmark Research

Fort Worth, Texas, United States

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DM Clinical Research

Houston, Texas, United States

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Texas Center for Drug Development, Inc.

Houston, Texas, United States

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DELRICHT RESEARCH at ZOMNIR FAMILY MEDICINE

McKinney, Texas, United States

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Research Your Health

Plano, Texas, United States

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Epic Medical Research, LLC

Red Oak, Texas, United States

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Clinical Trials of Texas, Inc

San Antonio, Texas, United States

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DM Clinical Research

Sugar Land, Texas, United States

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Breco Research - A Tarheel Clinical Research Site

Sugar Land, Texas, United States

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Cope Family Medicine

Bountiful, Utah, United States

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Olympus Family Medicine/CCT Research

Holladay, Utah, United States

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CenExel - JBR

Salt Lake City, Utah, United States

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South Ogden Family Medicine clinic/CCT

South Ogden, Utah, United States

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Velocity Clinical Research - Salt Lake City

West Jordan, Utah, United States

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Meridian Clinical Research

Portsmouth, Virginia, United States

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Clinical Research Partners, LLC

Richmond, Virginia, United States

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Lakeview Medical Center

Suffolk, Virginia, United States

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MHAT Sveti Ivan Rilski

Kozloduy, , Bulgaria

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MC City Clinic Sveti Georgi - Montana

Montana, , Bulgaria

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MHAT "Dr. Stamen Iliev

Montana, , Bulgaria

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Medical Center Medconsult Pleven

Pleven, , Bulgaria

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Military Medical Academy

Sofia, , Bulgaria

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SHAT of Pneumo-phthisiatric diseases - Sofia District

Sofia, , Bulgaria

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Aggarwal and Associates LTD

Brampton, , Canada

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Aviva Clinical Trials Group Inc

Burlington, , Canada

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Hamilton Medical Research Group

Hamilton, , Canada

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Okanagan Clinical Trials

Kelowna, , Canada

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Centricity Research Quebec City

Lévis, , Canada

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Milestone Research Inc.

London, , Canada

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Yang Medicine

Ottawa, , Canada

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LMC Manna

Pointe-Claire, , Canada

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DIEX Research Quebec Inc.

Québec, , Canada

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DIEX Research Quebec Inc.

Québec, , Canada

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Alpha Recherche Clinique Inc

Québec, , Canada

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Clinique de Lebourgneuf

Québec, , Canada

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Clinique spécialisée en allergie - Allergy/Immunology/Asthma/Mpoc

Québec, , Canada

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Diex Research Sherbrooke Inc

Québec, , Canada

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Central Alberta Research Clinic

Red Deer, , Canada

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Diex Recherche - Joilette - HyperCore - PPDS

Saint-Charles-Borromée, , Canada

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Glencar Medical Inc.

Sarnia, , Canada

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Canadian Phase Onward Inc.

Toronto, , Canada

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LMC

Toronto, , Canada

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Manna Research

Toronto, , Canada

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Medicine Professional Corporation

Toronto, , Canada

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Toronto Western Hospital

Toronto, , Canada

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Diex Recherche Trois-Rivières

Trois-Rivières, , Canada

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Colchester East Hants Health Authority - Colchester Regional

Truro, , Canada

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Diex Recherche Victoriaville

Victoriaville, , Canada

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Aarhus Universitetshospital

Århus N, , Denmark

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Odense University Hospital

Odense, , Denmark

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Sjællands UniHosp, Roskilde - Medicine and Infectious Diseases

Roskilde, , Denmark

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Center for Clinical and Basic Research

Tallinn, , Estonia

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Innomedica OÜ

Tallinn, , Estonia

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Merelahe Family Doctors Centre

Tallinn, , Estonia

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Clinical Research Center

Tartu, , Estonia

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Berliner Centrum für Reise- und Tropenmedizin

Berlin, , Germany

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Emovis GmbH

Berlin, , Germany

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Klinische Forschung Berlin-Mitte GmbH

Berlin, , Germany

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Klinische Forschung Berlin

Berlin, , Germany

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University Hospital Cologne AöR

Cologne, , Germany

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Klinische Forschung Dresden GmbH

Dresden, , Germany

Site Status

Medizentrum Essen Borbeck

Essen, , Germany

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IKF Pneumologie

Frankfurt, , Germany

Site Status

Infektiologikum Frankfurt-Sachsenhausen

Frankfurt, , Germany

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Studienzentrum Dr. Keller

Frankfurt am Main, , Germany

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Clinical Research Hamburg GmbH

Hamburg, , Germany

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Klinische Forschung Hamburg GmbH

Hamburg, , Germany

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Klinische Forschung Hannover-Mitte GmbH

Hanover, , Germany

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Siteworks GmbH

Hanover, , Germany

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Siteworks GmbH

Heidelberg, , Germany

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Synexus Clinical Research GmbH

Leipzig, , Germany

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Praxis Illies

Magdeburg, , Germany

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Dermatologie Quist

Mainz, , Germany

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Praxis Schaum

Oldenburg, , Germany

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Klinische Forschung Schwerin GmbH

Schwerin, , Germany

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Hautarztpraxis Leitz & Kollegen

Stuttgart, , Germany

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Studienzentrum Brinkum

Wardenburg, , Germany

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Leids Universitair Medisch Centrum (LUMC)

Leiden, , Netherlands

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Universitair Medisch Centrum (UMC) Utrecht - Julius Center for Health Sciences and Primary Care

Utrecht, , Netherlands

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Centrum Medyczne Pratia Bydgoszcz

Bydgoszcz, , Poland

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Centrum Medyczne Plejady

Krakow, , Poland

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Krakowskie Centrum Medyczne Sp. z o.o.

Krakow, , Poland

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Centrum Medyczne AMED Oddzial w Lodzi

Lodz, , Poland

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ETG Lublin

Lublin, , Poland

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KO-MED Centra Kliniczne Lublin II

Lublin, , Poland

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ETG Skierniewice

Skierniewice, , Poland

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Centrum Innowacyjnych Terapii Sp. z o.o.

Warsaw, , Poland

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Provita Centrum Medyczne Sp. z o.o.

Warsaw, , Poland

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RCMed

Warsaw, , Poland

Site Status

ETG Zamosc

Zamość, , Poland

Site Status

KO-MED Centra Kliniczne Sp. z o.o.

Zamość, , Poland

Site Status

Hospital de Antequera

Antequera, , Spain

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Hospital Clinic De Barcelona

Barcelona, , Spain

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Hospital Santa Creu i Sant Pau - Research institut

Barcelona, , Spain

Site Status

Universitat Autonoma de Barcelona (UAB) - Institut d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol)

Barcelona, , Spain

Site Status

Hospital Alvaro Cunqueiro

Vigo, , Spain

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Hospital Povisa

Vigo, , Spain

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Kaohsiung Veterans General Hospital

Kaohsiung City, , Taiwan

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China Medical University Hospital - division of Rheumatology - Taichung

Taichung, , Taiwan

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National Cheng Kung University hospital

Tainan City, , Taiwan

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National Taiwan University Hospital - Family Medicine

Taipei, , Taiwan

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Taipei Medical University - Taipei Medical University Hospital

Taipei, , Taiwan

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Taipei Medical University - WanFang Hospital

Taipei, , Taiwan

Site Status

Tri-Service General Hospital - Neihu Branch - Infectious Diseases

Taipei, , Taiwan

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Royal United Hospital

Bath, , United Kingdom

Site Status

Layton Medical Centre

Blackpool, , United Kingdom

Site Status

Hull University Teaching Hospitals NHS Foundation trust

Hull, , United Kingdom

Site Status

University Hospitals of Leicester-Leicester Royal Hospital

Leicester, , United Kingdom

Site Status

Liverpool University Hospitals NHS Foundation Trust - Aintree University Hospital (Fazakerley Hospital)

Liverpool, , United Kingdom

Site Status

GST NHS Found

London, , United Kingdom

Site Status

Newcastle University - Institute of Cellular Medicine (ICM)

Newcastle, , United Kingdom

Site Status

Panthera Biopartners - Manchester - multispeciality

Rochdale, , United Kingdom

Site Status

Panthera Biopartners - Sheffield - multispeciality

Rochdale, , United Kingdom

Site Status

Panthera Biopartners - Preston - multispeciality

Salford, , United Kingdom

Site Status

Southampton General Hospital

Southampton, , United Kingdom

Site Status

Royal Cornwall Hospitals Trust - Respiratory

Truro, , United Kingdom

Site Status

Countries

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United States Bulgaria Canada Denmark Estonia Germany Netherlands Poland Spain Taiwan United Kingdom

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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2022-001638-12

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

mRNA-1010-P302

Identifier Type: -

Identifier Source: org_study_id

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