CGMIS 48-hour Feasibility Study

NCT ID: NCT05562206

Last Updated: 2022-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-30

Study Completion Date

2022-11-30

Brief Summary

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This is a single center, single arm non-randomized study of 48-hour CGMIS wear duration incorporating two meal-challenge tests to explore the performance of a single insertion combined glucose-sensing insulin delivery cannula.

Detailed Description

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Conditions

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Type1diabetes

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Study group

All subjects using the study device

Group Type EXPERIMENTAL

CGMIS (Continuous Glucose Monitoring Infusion Set)

Intervention Type DEVICE

An integrated combination CGM/insulin infusion system

Interventions

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CGMIS (Continuous Glucose Monitoring Infusion Set)

An integrated combination CGM/insulin infusion system

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Type 1 diabetes, present for at least 6 months. If there is lack of clarity regarding the type of diabetes, the PI will make the final decision based on medical records.
* Age 18-75
* Currently using a Tandem T-Slim or Medtronic 523/723 or newer series insulin pump to treat their diabetes.
* Hgb A1C between 5.8 and 10%
* Willingness to follow all study procedures and to attend all clinic visits.
* Willingness to sign informed consent and HIPPA documents.

Exclusion Criteria

* Need for MRI/CT/Diathermy during study participation
* Current use of Hydroxyurea
* History of chronic kidney disease
* Inability to read pump or CGM display due to reduced visual acuity
* History of unstable ischaemic heart disease or myocardial infarction within the last 3 months.
* History of chronic liver disease
* Active infection such as HIV or hepatitis
* Anemia defined by HCT at least 4 percentage points below lower limit of the reference range
* Dementia, Schizophrenia or other untreated mental illness
* Chronic substance abuse
* Chronic alcohol abuse
* Seizure disorder
* Major surgical operation within 30 days prior to screening
* History of bleeding disorder or treatment with anticoagulants.
* Allergy to acrylate-based skin adhesives
* Ongoing use of an investigational drug or device
* Female of childbearing potential who is pregnant or intending to become pregnant
* Diabetic ketoacidosis or hypoglycemia requiring hospitalization within the last 6 months
* Insulin resistance as defined by insulin requirement of more than 200 units per day
* Use of glucose-lowering medications other than insulin
* Need for uninterrupted treatment with acetaminophen
* Any other physical or mental condition judged by the PI as being exclusionary.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pacific Diabetes Technologies

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Rainier Clinical Research Center

Renton, Washington, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Bob Janowski

Role: CONTACT

Phone: 818-395-6576

Email: [email protected]

Facility Contacts

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Ronald Brazg, MD

Role: primary

Other Identifiers

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CIP-01

Identifier Type: -

Identifier Source: org_study_id