IPSC Repository of Pediatric Cardiovascular Disease

NCT ID: NCT05550324

Last Updated: 2025-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-02

Study Completion Date

2030-12-31

Brief Summary

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Obtain blood samples for generation and maintenance of induced pluripotent stem cells (iPSCs) and genomic/DNA sequencing for biomedical research that will improve the understanding and treatment of pediatric cardiovascular disease

Detailed Description

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Human induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell which can be generated from easily accessible patient cells, such as peripheral blood mononuclear cells and skin fibroblasts. As iPSCs are epigenetically reprogrammed from somatic cells, they retain all genetic information of the affected patients, thus providing an ideal model for studying the contribution of genetic variation to pediatric cardiovascular disease. In addition, human iPSCs can be differentiated into cardiomyocytes, endothelial cells, smooth muscle cells and cardiac fibroblasts, which are major affected cell types in the heart responsible for cardiovascular disease. Therefore, patient-specific iPSCs possess great promise in modeling pediatric cardiovascular disease, discovering novel drugs and prospective cell regeneration therapy.

The DNA from these patients will be analyzed for point mutations, rare sequence variations, single nucleotide polymorphisms in known cardiac development genes or for chromosomal copy number changes by using state of the art genetic approaches.

Conditions

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Congenital Heart Disease Heart Diseases

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Study Groups

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Affected Subjects

The subjects must have the diagnosis of cardiovascular disease

Blood draw

Intervention Type PROCEDURE

One time intravenous blood draw

Syndromes associated with Cardiovascular Disease

The subject must have a syndrome associated with cardiovascular disease

Blood draw

Intervention Type PROCEDURE

One time intravenous blood draw

Family Members

The subject must be related to an individual in cohort 1 or 2

Blood draw

Intervention Type PROCEDURE

One time intravenous blood draw

Controls

The subject is considered a control and does not fall into any of the other cohorts

Blood draw

Intervention Type PROCEDURE

One time intravenous blood draw

Interventions

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Blood draw

One time intravenous blood draw

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. The subjects must have the diagnosis of cardiovascular disease
2. The subject must have a syndrome associated with cardiovascular disease
3. The subject must be related to an individual in cohort 1 or 2
4. The subject is considered a control and does not fall into any of the other cohorts

Exclusion Criteria

N/A
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Mingtao Zhao

OTHER

Sponsor Role lead

Responsible Party

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Mingtao Zhao

Research Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Jade F Hayden, BSN

Role: CONTACT

16143555648

Facility Contacts

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Jade Hayden

Role: primary

16143555648

Other Identifiers

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STUDY00001788

Identifier Type: -

Identifier Source: org_study_id

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