Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment

NCT ID: NCT05540613

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

315 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-01

Study Completion Date

2026-01-31

Brief Summary

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This randomized controlled trial aims to evaluate the effectiveness of Tai Chi and conventional exercise on improving cognitive function in older adults with mild cognitive impairment (MCI). Participants will be randomized into three six-month programmes, namely Health Education group, Tai Chi group and Conventional Exercise group. Assessments will be conducted at baseline, after the 26-week interventions, and 26-week after the competition of the intervention.

Detailed Description

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Conditions

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Mild Cognitive Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Health Education

A 26 weeks brain health and general health education program with two 1.5-hour sessions weekly.

Group Type SHAM_COMPARATOR

Health Education

Intervention Type BEHAVIORAL

A 26 weeks brain health and general health education program with two 1.5-hour sessions weekly.

Conventional Exercise

A 26 weeks Conventional Exercise training with two 1.5-hour sessions weekly.

Group Type ACTIVE_COMPARATOR

Conventional Exercise

Intervention Type BEHAVIORAL

A 26 weeks Conventional Exercise training with two 1.5-hour sessions weekly.

Tai Chi

A 26 weeks Tai Chi training with two 1.5-hour sessions weekly.

Group Type EXPERIMENTAL

Tai Chi

Intervention Type BEHAVIORAL

A 26 weeks Tai Chi training with two 1.5-hour sessions weekly.

Interventions

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Health Education

A 26 weeks brain health and general health education program with two 1.5-hour sessions weekly.

Intervention Type BEHAVIORAL

Conventional Exercise

A 26 weeks Conventional Exercise training with two 1.5-hour sessions weekly.

Intervention Type BEHAVIORAL

Tai Chi

A 26 weeks Tai Chi training with two 1.5-hour sessions weekly.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Chinese older adults aged equal or larger than 50 years
* Ethnic Chinese
* MCI under criteria of Mayo Clinic, including the following

i. people with subjective complaint about a decline in cognitive function. ii. total score in the Montreal Cognitive Assessment is equal or below the 7th percentile of the age- and education- corrected normative data of Hong Kong. iii. the decline in cognitive function does not impair daily functioning, as revealed by getting ≥2 marks in every item on the Chinese Lawton Instrumental Activities of Daily Living 4-point Scale).

Exclusion Criteria

* medical history of major chronic diseases such as cancer, stroke, cerebro- and cardio-vascular diseases, and renal disease
* uncontrolled diabetes
* diagnosed with dementia or using anti-dementia medication
* diagnosed with psychiatric diseases or using psychiatric medication
* with diseases or on medications known to severely affect cognitive performance
* somatic condition (e.g., limb lost) that prevent participation in exercise
* impaired mobility by chronic diseases (e.g., neurological, musculoskeletal and autoimmune diseases)
* incapable to perform physical exercise
* regular exercise habit (\>3 times 60-min Tai Chi or moderate-intensity conventional exercise weekly) in the past 3 months
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Parco Siu, PhD

Role: PRINCIPAL_INVESTIGATOR

The University of Hong Kong

Locations

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The University of Hong Kong

Hong Kong, , Hong Kong

Site Status RECRUITING

Countries

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Hong Kong

Central Contacts

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Pak Hung Yu, PhD

Role: CONTACT

Phone: 67533806

Email: [email protected]

Parco Siu, PhD

Role: CONTACT

Facility Contacts

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Pak Hung Yu, Mphil

Role: primary

Other Identifiers

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TC_MCI_RCT

Identifier Type: -

Identifier Source: org_study_id