A Study of PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors

NCT ID: NCT05538572

Last Updated: 2024-07-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-27
• Study Completion Date: 2024-06-26

Brief Summary

This is a Phase 1 dose-escalation study of PRT3645, a Cyclin-dependent Kinase 4/6 (CDK4/6) inhibitor, in patients with advanced or metastatic solid tumors. The purpose of this study is to investigate the safety, tolerability, dose limiting toxicity, and to determine maximally tolerated dose and recommended phase 2 dose to be used in subsequent development of PRT3645.

Detailed Description

This is an open-label, multicenter, dose-escalation Phase 1 study of PRT3645, a CDK4/6 inhibitor, evaluating patients with selected advanced or metastatic solid tumors including breast cancer (BC), glioblastoma (GBM), non-small cell lung cancer (NSCLC), sarcomas, head and neck squamous cell carcinoma (HNSCC), malignant mesothelioma, and endometrial cancer. The study plan expects to evaluate approximately eight dose levels however additional dose levels may be explored. Taking into account pharmacokinetic and pharmacodynamic data from the preceding dose levels, the dose may be escalated until a dose limiting toxicity is identified. Up to 15 patients may be enrolled at a dose shown to be tolerated for confirmation of the MTD and/or RP2D.

Conditions

Breast Cancer; Glioblastoma; Head and Neck Squamous Cell Carcinoma; Malignant Mesothelioma; Non-small Cell Lung Cancers; Sarcoma; Endometrial Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

PRT3645

PRT3645 capsules will be self-administered once daily, continuously, at the dose-level assigned

Group Type: EXPERIMENTAL

PRT3645

Intervention Type: DRUG

PRT3645 capsules will be self-administered once daily, continuously, at the dose-level assigned

Interventions

PRT3645

PRT3645 capsules will be self-administered once daily, continuously, at the dose-level assigned

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Histologically confirmed advanced, recurrent, or metastatic solid tumor malignancy that have either progress or ineligible for standard of care therapy:

1. HR+ and HER2- or HR+ and HER2+ breast cancer

2. Recurrent GBM (IDH wild type) or CDKN2A/B homozygous deleted IDH-mutant astrocytoma

3. KRAS-mutant or SMARCA4 loss NSCLC

4. CDK pathway alternation in any of the following tumor types: malignant mesothelioma, HPV-negative HNSCC (including oral cavity, oropharynx, hypopharynx, and larynx), sarcoma, or NSCLC

5. Estrogen receptor positive with TP53 wild type endometrial cancer

• Willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures
• Must have measurable or non-measureable (but evaluable) disease
• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 or Karnofsky Performance Status (KPS) ≥80% (KPS is for GBM only)
• Adequate organ function.
• Able to swallow and retain oral medication.
• Must provide either archival or fresh tumor tissue sample during screening.

Exclusion Criteria

• Participants with advanced, symptomatic, extensive visceral disease.
• Active inflammatory bowel disease or chronic diarrhea, short bowel syndrome, any upper gastrointestinal surgery including gastric resection, known malabsorption syndrome, or other condition that may impair absorption of PRT3645.
• Treatment with strong inhibitors of CYP3A4.
• History of another malignancy within 3 years except for adequately treated basal cell or squamous cell skin cancer, superficial bladder cancer, prostate intraepithelial neoplasm, carcinoma in situ of the cervix, or other noninvasive or indolent malignancies, or malignancies previously treated with curative intent and not on active therapy or expected to require treatment or recurrence during the study.
• Clinically significant or uncontrolled cardiac disease, uncontrolled electrolyte disorders, uncontrolled or symptomatic CNS metastases or leptomeningeal disease except for GBM.
• Endometrial cancer patients who had received prior treatment with a CDK 4/6 inhibitor.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Prelude Therapeutics

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Smilow Cancer Hospital Phase 1 Unit

New Haven, Connecticut, United States

AdventHealth Medical Group Oncology Research at Celebration

Celebration, Florida, United States

Miami Cancer Institute

Miami, Florida, United States

Florida Cancer Specialists

Sarasota, Florida, United States

Winship Cancer Institute, Emory University

Atlanta, Georgia, United States

Laura and Isaac Perlmutter Cancer Center/ NYU Langone Health

New York, New York, United States

Cleveland Clinic

Cleveland, Ohio, United States

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Thomas Jefferson University, Sidney Kimmel Cancer Center

Philadelphia, Pennsylvania, United States

Tennessee Oncology, PLLC

Nashville, Tennessee, United States

South Texas Accelerated Research Therapeutics, LLC

San Antonio, Texas, United States

NEXT Virginia

Fairfax, Virginia, United States

National Cancer Centre Singapore

Singapore, , Singapore

Countries

United States; Singapore

Other Identifiers

PRT3645-01

Identifier Type: -

Identifier Source: org_study_id