Semi-automated Segmentation Methods of SSTR PET for Dosimetry Prediction

NCT ID: NCT05537675

Last Updated: 2023-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-01

Study Completion Date

2022-11-30

Brief Summary

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Tumor dosimetry with somatostatin receptor-targeted peptide receptor radionuclide therapy (SSTR-targeted PRRT) by 177Lutetium-DOTATATE might contribute to improve follow-up and treatment response of refractory meningiomas. This study aims to evaluate Standard Uptake Value mean (SUVmean) as a tumoral absorbed dose predictive predictive factor and propose semi-automated segmentation method to determine metabolic tumor volume with pretherapeutic 68-Gallium-DOTATOC PET.

Detailed Description

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Conditions

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Refractory Meningioma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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20 patients with meningioma

20 meningioma patients will be included in this study, 10 of whom will have been treated with Lutathera®.

To evaluate the SUVmean (Standard Uptake Value) as a predictive factor of the tumor absorbed dose compared to the SUVmax

Intervention Type OTHER

Measure SUVmean (Standard Uptake Value) and SUVmax on PET exams

10 patients will have been treated with Lutathera®.

10 patients of the 20 will have been treated with Lutathera®.

To evaluate the SUVmean (Standard Uptake Value) as a predictive factor of the tumor absorbed dose compared to the SUVmax

Intervention Type OTHER

Measure SUVmean (Standard Uptake Value) and SUVmax on PET exams

Interventions

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To evaluate the SUVmean (Standard Uptake Value) as a predictive factor of the tumor absorbed dose compared to the SUVmax

Measure SUVmean (Standard Uptake Value) and SUVmax on PET exams

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with meningioma

Exclusion Criteria

\- PET scan not available
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role lead

Responsible Party

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Antoine VERGER

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anne-Sophie HUE, MSc

Role: STUDY_DIRECTOR

CHRU Nancy

Locations

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Nuclear medicine Department CHRU de NANCY

Vandœuvre-lès-Nancy, , France

Site Status

Countries

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France

Other Identifiers

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2022PI

Identifier Type: -

Identifier Source: org_study_id