Phenotyping and Genotyping of Duffy Antigen

NCT ID: NCT05527119

Last Updated: 2023-11-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-03-11
• Study Completion Date: 2023-09-11

Brief Summary

Malaria remains the world's leading parasitic endemic. Almost half of the world's population lives in endemic areas. Many at-risk people in African countries remain without access to malaria control. Malaria kills approximately 400,000 people each year, most of whom are children under the age of 5 in Africa. Since 2005, an increasing number of Plasmodium vivax infections have been observed in Duffy-negative populations in South America and Africa, calling into question the essential role of the PvDBP-DARC interaction. The objective of the investigators is therefore to study and understand the invasion pathways used by Plasmodium vivax in Duffy-negative subjects.

Conditions

Plasmodium Vivax

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Major subjects
• with malaria and willing to have their blood samples analyzed for this research

Exclusion Criteria

• Subjects refusing to participate in the study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Strasbourg, France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Didier MENARD, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Service Laboratoire de Parasitologie et Mycologie Médicale-PTM - CHU de Strasbourg - France

Locations

Service de Laboratoire de Parasitologie et Mycologie Médicale-PTM - CHU de Strasbourg - France

Strasbourg, , France

Countries

France

Other Identifiers

8543

Identifier Type: -

Identifier Source: org_study_id