Mechanism of Serum PRL in the Development of MAFLD

NCT ID: NCT05525884

Last Updated: 2022-09-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2024-01-31

Brief Summary

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Metabolic associated fatty liver disease (MAFLD) has currently reached a worldwide epidemic. Serum PRL levels within or outside physiological range have been found to affect metabolic homeostasis differently. However, the relationship between serum PRL and MAFLD among diabetic patients is unclear. The investigators aimed to explore the association between serum PRL and the risk of MAFLD in patients with type 2 diabetes (T2DM).

Detailed Description

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Conditions

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Type2 Diabetes Fatty Liver, Nonalcoholic Liver Fibrosis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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MAFLD and Non-MAFLD

non-invasive method, Fibroscan

Intervention Type OTHER

Liver Ultrasound and transient elastography (FibroScan®)

Steatosis and Non-Steatosis

non-invasive method, Fibroscan

Intervention Type OTHER

Liver Ultrasound and transient elastography (FibroScan®)

Fibrosis and Non-Fibrosis

non-invasive method, Fibroscan

Intervention Type OTHER

Liver Ultrasound and transient elastography (FibroScan®)

Interventions

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non-invasive method, Fibroscan

Liver Ultrasound and transient elastography (FibroScan®)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* aged 18\~65 years old,
* underwent the laboratory tests, hepatic ultrasonography, and valid transient elastography (FibroScan) examination

Exclusion Criteria

* other known chronic liver diseases, such as chronic hepatitis B or C, autoimmune hepatitis, and haemochromatosis
* pre-existing active cancer, renal dysfunction, severe liver dysfunction, congestive heart failure or free abdominal fluid
* history of hyperthyroidism or hypothyroidism, pituitary diseases, and other types of diabetes
* significant alcohol consumption
* pregnancy
* receiving any therapeutic methods that could lead to liver steatosis or fibrosis, influence the glucolipid metabolism, or PRL levels, such as lipid-lowering, and PRL-lowering agents (bromocriptine) within 6 months prior to this study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shen Qu

OTHER

Sponsor Role lead

Responsible Party

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Shen Qu

Principle investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Shanghai Tenth People's Hospital

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Shen Qu

Role: CONTACT

+862166301064

Facility Contacts

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Shen Qu, PHD

Role: primary

+8613636600255

Other Identifiers

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PRL

Identifier Type: -

Identifier Source: org_study_id

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