Autologous Immune Enhancement Therapy (AIET) for Cancer Patients

NCT ID: NCT05520372

Last Updated: 2022-08-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-01

Study Completion Date

2021-12-30

Brief Summary

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This is a retrospective study that included 60 cancer patients who underwent autologous NK cell and CD8 T cell therapy between January 2016 and December 2021

Detailed Description

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The dysfunction and reduced proliferation of peripheral immune cells including CD8 T and NK cells have been observed in both aging and cancer patients, thereby challenging the immune cell therapy in these subjects. Therefore, we evaluated the growth of these lymphocytes in elderly patients with several types of cancer and the correlation of peripheral blood (PB) indexes to the expansions. This is a retrospective study that included 60 cancer patients who underwent autologous NK cell and CD8 T cell therapy between January 2016 and December 2021. By optimizing the antiviral and tumor surveillance ability of both NK cells and CTLs through serial steps from isolation and expansion, followed by re-infusion of these activated cells back to the patient body, AIET has become a promising, cutting-edge method in detecting and eliminating cancer cells. The study aimed to evaluate the safety and effectiveness of 60 cancer patientsreceiving AIET.

Conditions

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Patients With Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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autologous immune enhancement therapy (AIET) for treating cancer

A total of 60 cancer patients received one to seven sittings of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) infusions.

Group Type EXPERIMENTAL

Autologous immune enhancement therapy (AIET) for cancer patients

Intervention Type COMBINATION_PRODUCT

Autologous NK cell and CD8 T cell therapy for cancer patients

Interventions

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Autologous immune enhancement therapy (AIET) for cancer patients

Autologous NK cell and CD8 T cell therapy for cancer patients

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* Patients aged 18 - 75
* Patients have been diagnosed with cancer.
* Patients signed the written informed consent form.

Exclusion Criteria

* Severe health conditions such as serious infection, autoimmune diseases, or using any anti-rejection drugs
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Vinmec Research Institute of Stem Cell and Gene Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Liem Nguyen Thanh, PhD

Role: PRINCIPAL_INVESTIGATOR

Vinmec Research Institute of Stem Cell and Gene Technology

Locations

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Vinmec Research Institute of Stem Cell and Gene Technology

Hanoi, , Vietnam

Site Status

Countries

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Vietnam

Other Identifiers

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AIET_2022

Identifier Type: -

Identifier Source: org_study_id

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