Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
148 participants
OBSERVATIONAL
2019-03-01
2019-10-31
Brief Summary
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A total of 148 women (PMW, n=76,RMW, n=72) received a comprehensive medical assessment and a full-mouth oral examination. The corresponding bone mineral density (BMD) and body mass indices (BMI) were obtained from their medical records.
Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Post-menopausal women
Periodontal clinical examination and gingival crevicular fluid, saliva, dental plaque, serum sampling
Probing pocket depth was defined as the distance in millimeters from the gingival margin to the base of the gingival sulcus measured using a manual probe (Michigan 0 probe with Williams Markings) in all the teeth present except for third molars. Similarly, clinical attachment level (CAL) was measured as distance from cementoenamel junction to the base of pocket and recorded manually to the nearest millimeter marking on probe.
1 mililiter of saliva was obtained by each participant. Subgingival dental plaque was collected with sterile endodontic paperpoints from mesial sides of each natural teeth without a prostethic restoration. Gingival crevicular fluid samples were collected with absorbent paper strips. Serum samples were also collected at the time of visit.
Regularly mensturating women
Periodontal clinical examination and gingival crevicular fluid, saliva, dental plaque, serum sampling
Probing pocket depth was defined as the distance in millimeters from the gingival margin to the base of the gingival sulcus measured using a manual probe (Michigan 0 probe with Williams Markings) in all the teeth present except for third molars. Similarly, clinical attachment level (CAL) was measured as distance from cementoenamel junction to the base of pocket and recorded manually to the nearest millimeter marking on probe.
1 mililiter of saliva was obtained by each participant. Subgingival dental plaque was collected with sterile endodontic paperpoints from mesial sides of each natural teeth without a prostethic restoration. Gingival crevicular fluid samples were collected with absorbent paper strips. Serum samples were also collected at the time of visit.
Interventions
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Periodontal clinical examination and gingival crevicular fluid, saliva, dental plaque, serum sampling
Probing pocket depth was defined as the distance in millimeters from the gingival margin to the base of the gingival sulcus measured using a manual probe (Michigan 0 probe with Williams Markings) in all the teeth present except for third molars. Similarly, clinical attachment level (CAL) was measured as distance from cementoenamel junction to the base of pocket and recorded manually to the nearest millimeter marking on probe.
1 mililiter of saliva was obtained by each participant. Subgingival dental plaque was collected with sterile endodontic paperpoints from mesial sides of each natural teeth without a prostethic restoration. Gingival crevicular fluid samples were collected with absorbent paper strips. Serum samples were also collected at the time of visit.
Eligibility Criteria
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Inclusion Criteria
* Having history of spontaneous amenorrhea for the last 12 months for PMW.
* Lack of irregularity in menstrual cycles during the past 12 months for RMPW.
* Possessing at least 10 natural teeth without any prosthetic restoration
Exclusion Criteria
* Ongoing cancer therapy
* Presence of oral ulcers or acute infectious disease
* Presence of diabetes mellitus
35 Years
65 Years
FEMALE
Yes
Sponsors
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Karolinska Institutet
OTHER
Ege University
OTHER
Responsible Party
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Gülnur Emingil
Prof. Dr.
Locations
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Ege University Faculty of Dentistry
Izmir, , Turkey (Türkiye)
Countries
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Other Identifiers
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TOA-2020-21085
Identifier Type: -
Identifier Source: org_study_id