Trial Outcomes & Findings for Investigating Transcranial Alternating Current Stimulation (tACS) Preconditioning Effects on Resting and Active Motor Threshold (NCT NCT05503823)
NCT ID: NCT05503823
Last Updated: 2023-10-06
Results Overview
The peak-to-peak amplitude of the muscle signal from the resting motor threshold.
Recruitment status
TERMINATED
Study phase
NA
Target enrollment
6 participants
Primary outcome timeframe
Before tACS, right after tACS, 30 minutes after tACS, and 1 hour after tACS
Results posted on
2023-10-06
Participant Flow
Participant milestones
| Measure |
All Study Participants
Each participant will have their resting and active motor threshold measured using the transcranial magnetic stimulation (TMS) device. Participants will receive tACS for 10 minutes in the first session and tRNS in the second session.
tACS or tRNS and TMS: A light electrical current will be applied to the scalp of the participants via 2 electrodes. The resting and active motor threshold will be measured before, right after, after 30 minutes, and after 1 hour of receiving the tACS or tRNS.
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|---|---|
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Overall Study
STARTED
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6
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Overall Study
COMPLETED
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6
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Overall Study
NOT COMPLETED
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0
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Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Participants
n=6 Participants
Each participant will have their resting and active motor threshold measured using the transcranial magnetic stimulation (TMS) device. Participants will receive tACS for 10 minutes in the first session and tRNS in the second session.
tACS or tRNS and TMS: A light electrical current will be applied to the scalp of the participants via 2 electrodes. The resting and active motor threshold will be measured before, right after, after 30 minutes, and after 1 hour of receiving the tACS or tRNS.
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|---|---|
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Age, Continuous
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29 years
STANDARD_DEVIATION 9.1 • n=6 Participants
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Sex: Female, Male
Female
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4 Participants
n=6 Participants
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Sex: Female, Male
Male
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2 Participants
n=6 Participants
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MoCA score
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27.9 units on a scale
STANDARD_DEVIATION 1.6 • n=6 Participants
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Handedness
Right handed
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4 Participants
n=6 Participants
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Handedness
Left handed
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2 Participants
n=6 Participants
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Amount of sleep the night before
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7.3 hours
STANDARD_DEVIATION 1.1 • n=6 Participants
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Anxiety
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1.7 units on a scale
STANDARD_DEVIATION 0.5 • n=6 Participants
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Pain medication
No
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6 Participants
n=6 Participants
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Pain medication
Yes
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0 Participants
n=6 Participants
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Caffeine within 1 hour prior to study
No
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5 Participants
n=6 Participants
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Caffeine within 1 hour prior to study
Yes
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1 Participants
n=6 Participants
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PRIMARY outcome
Timeframe: Before tACS, right after tACS, 30 minutes after tACS, and 1 hour after tACSThe peak-to-peak amplitude of the muscle signal from the resting motor threshold.
Outcome measures
| Measure |
Resting Motor Threshold With tACS
n=6 Participants
Each participant will have their resting motor threshold measured using the transcranial magnetic stimulation (TMS) device. Participants will receive tACS for 10 minutes.
tACS and TMS: A light electrical current will be applied to the scalp of the participants via 2 electrodes. The resting and active motor threshold will be measured before, right after, after 30 minutes, and after 1 hour of receiving the tACS or tRNS.
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|---|---|
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Resting Motor Threshold
Before
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76.5 micro Volts
Standard Deviation 26.6
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Resting Motor Threshold
After
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108.7 micro Volts
Standard Deviation 43.2
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Resting Motor Threshold
30 min After
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130.1 micro Volts
Standard Deviation 45
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Resting Motor Threshold
1 hour After
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85.8 micro Volts
Standard Deviation 25.1
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SECONDARY outcome
Timeframe: Before tACS, right after tACS, 30 minutes after tACS, and 1 hour after tACSPopulation: Majority of AMT data had significant noise, limiting the dataset to only 1 participant for all time frames.
Cortical silent period measured post-MEP.
Outcome measures
| Measure |
Resting Motor Threshold With tACS
n=1 Participants
Each participant will have their resting motor threshold measured using the transcranial magnetic stimulation (TMS) device. Participants will receive tACS for 10 minutes.
tACS and TMS: A light electrical current will be applied to the scalp of the participants via 2 electrodes. The resting and active motor threshold will be measured before, right after, after 30 minutes, and after 1 hour of receiving the tACS or tRNS.
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|---|---|
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Active Motor Threshold
Before
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131.1 milli seconds
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Active Motor Threshold
After
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123.1 milli seconds
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Active Motor Threshold
30 min After
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81.4 milli seconds
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Active Motor Threshold
1 hour After
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108.75 milli seconds
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Adverse Events
tACS Group
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
tRNS Group
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place