Use of Methazolamide to Lower Intraocular Pressure

NCT ID: NCT05498103

Last Updated: 2024-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE4

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-17

Study Completion Date

2024-12-31

Brief Summary

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The purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.

Detailed Description

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Conditions

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Glaucoma, Open-Angle

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors
Double

Study Groups

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Methazolamide 25 mg

Once a day \[q.d\] in the morning for 1 week, Twice a day \[b.i.d.\] in the morning and evening for 1 week

Group Type ACTIVE_COMPARATOR

Methazolamide 25 MG

Intervention Type DRUG

25 mg tablets

Methazolamide 50 mg

Once a day \[q.d\] in the morning for 1 week, Twice a day \[b.i.d.\] in the morning and evening for 1 week

Group Type ACTIVE_COMPARATOR

Methazolamide 50 MG

Intervention Type DRUG

50 mg tablets

Interventions

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Methazolamide 25 MG

25 mg tablets

Intervention Type DRUG

Methazolamide 50 MG

50 mg tablets

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Males and females between 50 and 90 years old
* Current diagnosis of open angle glaucoma (OAG) in both eyes
* Ability to read and write in English

Exclusion Criteria

* Glaucoma other than OAG
* Severe or end-stage glaucoma (cup to disc ratio \>0.8 or Mean Deviation on Visual Field worse than -12)
* Pregnant or breast-feeding women
Minimum Eligible Age

50 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Colorado, Denver

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Malik Y. Kahook, MD

Role: PRINCIPAL_INVESTIGATOR

University of Colorado, Denver

Locations

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Sue Anschutz-Rodgers Eye Center

Aurora, Colorado, United States

Site Status

Countries

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United States

Other Identifiers

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22-0721

Identifier Type: -

Identifier Source: org_study_id

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