The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain

NCT ID: NCT05491915

Last Updated: 2025-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-24

Study Completion Date

2027-08-31

Brief Summary

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The purpose of this study is to learn if pain can be relieved by delivering small amounts of electricity (called "electrical stimulation") to the nerves at the top of the neck. This study will use a device called the SPRINT® PNS System. PNS stands for peripheral nerve stimulation (PNS). This device is cleared by the FDA for up to 60 days of use for relief of chronic or acute pain.

Detailed Description

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Conditions

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Cervicogenic Headache Occipital Neuralgia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Peripheral Nerve Stimulation

All study subjects will have up to 2 leads placed in the back of their neck, will use the SPRINT Peripheral Nerve Stimulation (PNS) System, and will receive electrical stimulation.

Group Type EXPERIMENTAL

SPRINT Peripheral Nerve Stimulation (PNS) System

Intervention Type DEVICE

The SPRINT System delivers mild electrical stimulation to the occipital nerves. The SPRINT System includes up to two leads (small wires) that are placed through your skin at the top of your neck. The leads attach to devices worn on your body that deliver stimulation (called Stimulators).

Interventions

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SPRINT Peripheral Nerve Stimulation (PNS) System

The SPRINT System delivers mild electrical stimulation to the occipital nerves. The SPRINT System includes up to two leads (small wires) that are placed through your skin at the top of your neck. The leads attach to devices worn on your body that deliver stimulation (called Stimulators).

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diagnosed cervicogenic headache (CGH) or occipital neuralgia (ON)

Exclusion Criteria

* Prior cervical or cranial occipital surgery
* Implanted electronic device (dependent on implant's intended treatment, location, and electrical current pathway)
* Pregnant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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SPR Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Pacific Research Institute

Santa Rosa, California, United States

Site Status

MedVadis Research

Waltham, Massachusetts, United States

Site Status

Mayo Clinic Rochester

Rochester, Minnesota, United States

Site Status

Center of Clinical Research

Winston-Salem, North Carolina, United States

Site Status

Pain Specialists of America - South Austin - James Casey

Austin, Texas, United States

Site Status

Pain Specialists of America - Cedar Park

Cedar Park, Texas, United States

Site Status

Institute of Precision Pain Medicine

Corpus Christi, Texas, United States

Site Status

Pain Specialists of America - Round Rock

Round Rock, Texas, United States

Site Status

Pain Specialists of America - San Marcos

San Marcos, Texas, United States

Site Status

University of Utah

Salt Lake City, Utah, United States

Site Status

Countries

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United States

Related Links

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http://www.sprintpns.com

Sponsor's Website

Other Identifiers

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0156-CSP-000

Identifier Type: -

Identifier Source: org_study_id