Perinatal Mental Health Study (PMHS) India

NCT ID: NCT05485701

Last Updated: 2023-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2332 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-01

Study Completion Date

2026-08-31

Brief Summary

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The purpose of this observational study is to improve understanding of mental disorders among perinatal women in India.

Detailed Description

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The purpose of this observational study is to assess the mental health of perinatal women living in two low-income settings in India. The first phase will explore women's awareness of mental illness and acceptability of screening for mental disorders. The second phase will be a validation study, during which the psychometric properties of screening tools will be assessed against a gold standard. The third stage will comprise a cohort study, during which the prevalence of and risk factors for mental disorders among perinatal and non-perinatal women will be established.

Conditions

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Depression Anxiety Suicidal Ideation Somatization PTSD

Keywords

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Antenatal Perinatal Post-partum Low- and middle-income country India Common mental disorders Screening Validation Prevalence Risk factor

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Perinatal women

Women will be recruited in their first trimester of pregnancy and followed-up until 6 months post-partum. This is the 'exposed' group.

Screening tools for common mental disorders

Intervention Type DIAGNOSTIC_TEST

A number of screening tools will be administered which will establish the likelihood of depression, anxiety, PTSD, somatisation and suicidality.

Non-perinatal women

Non-perinatal women will be recruited as the 'non-exposed' group and followed-up over the same duration as the perinatal group.

Screening tools for common mental disorders

Intervention Type DIAGNOSTIC_TEST

A number of screening tools will be administered which will establish the likelihood of depression, anxiety, PTSD, somatisation and suicidality.

Interventions

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Screening tools for common mental disorders

A number of screening tools will be administered which will establish the likelihood of depression, anxiety, PTSD, somatisation and suicidality.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

For Phase 1 (qualitative study) and Phase 2 (validation study):

Pregnant women:

* Aged 18 to 45 years
* Currently pregnant (any trimester)
* Willing and able to give informed consent

Post-partum women:

* Aged 18 to 45 years
* Currently post-partum (between 1-12 months postpartum)
* Willing and able to give informed consent

Non-perinatal women:

* Aged 18 to 45 years
* Not currently pregnant and not given birth in the past 12 months
* Willing and able to give informed consent

For Phase 3 (prospective cohort study):

Perinatal women:

* Aged 18 to 45 years
* In early pregnancy (estimated gestational age \<20 weeks) at recruitment
* Not planning to relocate for the duration of the study period
* Willing and able to give informed consent
* Expressed a willingness to continue to participate for the four planned visits

Non-perinatal women:

* Aged 18 to 45 years
* Not currently pregnant and not given birth in the last 12 months
* Not planning to relocate for the duration of the study period
* Willing and able to give informed consent
* Expressed a willingness to continue to participate for the four planned visits

Exclusion Criteria

The participant may not enter the study if:

* They have an acutely severe psychiatric illness which impairs their ability to take part in the study
* They are not willing or able to provide informed consent

Other than for current severe psychiatric illness which affects ability to participate in the study, we will not exclude any participant on the basis of current or prior physical, psychological or psychiatric co-morbidities so long as she is willing to participate, her ability to take part is not compromised and her ability to give informed consent is not impaired by these conditions.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Mental Health and Neuro Sciences, India

OTHER

Sponsor Role collaborator

Dr. Rajendra Prasad Government Medical College

OTHER

Sponsor Role collaborator

University of Oxford

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gracia Fellmeth, DPhil

Role: PRINCIPAL_INVESTIGATOR

University of Oxford

Locations

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Dr Rajendra Prasad Government Medical College

Kangra, Himachal Pradesh, India

Site Status RECRUITING

National Institute of Mental Health and Neuro Sciences

Bengaluru, Karnataka, India

Site Status RECRUITING

Countries

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India

Central Contacts

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Gracia Fellmeth, DPhil

Role: CONTACT

Phone: 00441865289745

Email: [email protected]

Facility Contacts

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Ashok Verma

Role: primary

M. Thomas Kishore

Role: primary

References

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Fellmeth G, Kishore MT, Verma A, Desai G, Bharti O, Kanwar P, Singh S, Thippeswamy H, Chandra PS, Kurinczuk JJ, Nair M, Alderdice F. Perinatal mental health in India: protocol for a validation and cohort study. J Public Health (Oxf). 2021 Oct 8;43(Suppl 2):ii35-ii42. doi: 10.1093/pubmed/fdab162.

Reference Type BACKGROUND
PMID: 34622290 (View on PubMed)

Other Identifiers

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10-20

Identifier Type: -

Identifier Source: org_study_id