Surufatinib Combined With Sintilimab and AG in First-line Therapy of Patients With Locally Advanced or Metastatic Pancreatic Cancer

NCT ID: NCT05481476

Last Updated: 2025-09-04

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 32 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-12
• Study Completion Date: 2026-12-31

Brief Summary

This is a single-center, single-arm, open-label, phase 2 clinical study, to explore the efficacy and safety of surufatinib combined with sintilimab and AG in first-line therapy of patients with locally advanced or metastatic pancreatic cancer.

Conditions

Pancreatic Neoplasms

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

surufatinib combined with sintilimab and AG

Group Type: EXPERIMENTAL

Surufatinib

Intervention Type: DRUG

250mg, qd, po, 21 days for a cycle

Sintilimab

Intervention Type: DRUG

200mg, ivgtt, d1, 21 days for a cycle, up to 2 years

AG

Intervention Type: DRUG

nab-paclitaxel (125mg/ m2, ivgtt, d1, 8), Gemcitabine (1000mg/ m2, intravenous infusion over 30min, d1, 8), 21 days for a cycle, up to 6 cycles

Interventions

Surufatinib

250mg, qd, po, 21 days for a cycle

Intervention Type: DRUG

Sintilimab

200mg, ivgtt, d1, 21 days for a cycle, up to 2 years

Intervention Type: DRUG

AG

nab-paclitaxel (125mg/ m2, ivgtt, d1, 8), Gemcitabine (1000mg/ m2, intravenous infusion over 30min, d1, 8), 21 days for a cycle, up to 6 cycles

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Informed consent has been signed

2. Histologically or cytologically confirmed unresectable, locally advanced or metastatic pancreatic cancer

3. Age ≥ 18 years, ≤75 years, male or female

4. ECOG PS：0-1, expected overall survival ≥12 months

5. Patients who have not previously received systemic therapy for locally advanced or metastatic pancreatic cancer

6. Patients with distant metastases after surgery, who have received one regimen of adjuvant chemotherapy and have recurred > 6 months from adjuvant therapy can be enrolled

7. Patients must have at least one measurable liver metastases (RECIST 1.1)

8. No serious organic diseases of the heart, lungs, brain and other organs

9. Patients must have adequate organ and bone marrow function

10. Women of childbearing age must have a negative pregnancy test within the first day of the study, and contraceptive methods should be taken during the study until 6 months after the last administration

Exclusion Criteria

1. Participated in clinical trials of other anti-tumor drugs within 4 weeks before enrollment

2. Previously received VEGFR inhibitors or immune checkpoint inhibitors

3. Patients with BRCA1/2 germline mutations

4. Patients with obstructive jaundice but less than expected jaundice

5. Patients had other malignant tumors in the past 5 years, except for the cured skin basal cell carcinoma and cervical carcinoma in situ

6. Patients previously had brain metastasis or current brain metastasis

7. Investigator determines that the liver metastases account for 70% or more of the total liver volume

8. Received any operation (except biopsy) or invasive treatment or operation (except venous catheterization, puncture and drainage, internal/external drainage surgery for obstructive jaundice, etc.) within 4 weeks before enrollment

9. Received local anti-tumor therapy such as hepatic artery interventional embolization, cryoablation or radiofrequency ablation of liver metastases within 4 weeks before enrollment

10. Clinically significant electrolyte abnormality

11. Patient currently has uncontrolled hypertension, defined as: systolic blood pressure > 140mmHg or diastolic blood pressure > 90mmHg

12. Proteinuria ≥ 2+ (1.0g/24hr)

13. Patients whose tumor is highly likely to invade important blood vessels and cause fatal hemorrhage during the follow-up study period as judged by the investigator

14. Have evidence or history of bleeding tendency within 3 months, Significant bleeding symptoms or a clear bleeding tendency within 3 months before enrollment

15. Clinically significant cardiovascular disease, including but not limited to acute myocardial infarction, severe/unstable angina pectoris or coronary artery bypass grafting within 6 months before enrollment; NYHA classification > 2 Grade; ventricular arrhythmia requiring medical therapy; ECG showing QTc interval ≥ 480 ms

16. Active or uncontrolled serious infection (≥CTCAE grade 2 infection)

17. Unrelieved toxic reactions ≥ CTCAE grade 2 due to any previous anticancer treatment, excluding alopecia, lymphopenia and neurotoxicity of ≤ grade 2 caused by oxaliplatin

18. Pregnant or lactating women

19. Any other disease, with clinically significant metabolic abnormalities, physical examination abnormalities or laboratory abnormalities, according to the judgment of investigator that the patient is not suitable for the the study drug (such as having epileptic seizures and require treatment), or would affect the interpretation of study results, or put patients at high risk

20. Clinical confirmed human immunodeficiency virus (HIV) infection, history of clinically significant liver disease, including viral hepatitis (hepatitis B / C (HBV DNA Positive[1×104 copies/mL or >2000 IU/ml], HCV RNA positive[>1×103 copies/mL]), or other hepatitis, cirrhosis])

21. Patients with autoimmune disease or suspected autoimmune disease (including but not limited to: myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, enteritis, multiple Sclerosis, vasculitis, glomerulonephritis, uveitis, hypophysitis, hyperthyroidism, etc.)

22. Patients who are allergic or suspected to be allergic to the study drug or similar drugs

23. Patients have other factors that may affect the results of the study or cause the study to be terminated halfway, such as alcoholism, drug abuse, other serious diseases (including mental diseases) that require concomitant treatment, and serious laboratory abnormalities. Accompanied by family or social factors, which will affect the safety of patients

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sun Yat-sen University

OTHER

Sponsor Role: lead

Responsible Party

Dong sheng Zhang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Cancer center of SunYat-sen University

Guangzhou, Guangdong, China

Countries

China

Other Identifiers

HMPL-012-SPRING-P103

Identifier Type: -

Identifier Source: org_study_id