Characterizing Occupational Therapy Intervention for Children With Autism Spectrum Disorders
NCT ID: NCT05480605
Last Updated: 2025-11-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
2 participants
OBSERVATIONAL
2022-04-19
2024-11-04
Brief Summary
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Detailed Description
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This pilot feasibility study will examine behavioral and electroencephalography (EEG) measures of attention and sensory processing before and following 6-8 weeks of routine occupational therapy at community outpatient centers among 30 children with autism aged 6 - 13 years. The primary aim is to determine the feasibility, sensitivity, and validity of EEG measures of auditory processing as a response biomarker following routine occupational therapy intervention. Another aim is to examine the contribution of a child's engagement during therapy as a key predictor of change using behavioral and EEG outcome measures. The occupational therapy intervention consists of one-hour weekly sessions of usual care at Nationwide Children's Hospital outpatient centers.
Results from this grant will provide valuable proof-of-concept data establishing engagement during therapy as an active ingredient in occupational therapy intervention using neurophysiological and behavioral measures. These results will also establish the validity of EEG measures as sensitive to a child's level of engagement and neuroplastic changes following occupational therapy intervention.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Experimental Group
Children with autism ages 6-13
Occupational Therapy
Children with autism will receive 6 - 8 weeks of regularly scheduled occupational therapy at Nationwide Children's Hospital outpatient centers. The intervention consists of one-hour weekly sessions with a licensed occupational therapist.
Interventions
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Occupational Therapy
Children with autism will receive 6 - 8 weeks of regularly scheduled occupational therapy at Nationwide Children's Hospital outpatient centers. The intervention consists of one-hour weekly sessions with a licensed occupational therapist.
Eligibility Criteria
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Inclusion Criteria
* a medical diagnosis of Autism
* between 8 - 13 years
* must be verbal
* have normal or corrected vision/hearing
* enrollment in the 8-week OT treatment plan with a therapist enrolled in the study.
For typically developing children:
• No history of neurological injuries, disabilities, and family history of mental health disorders on parent report
Exclusion Criteria
* presence of a severe chronic medical disorder
* presence of a major visual impairment
* history of alcohol/substance abuse or dependency.
6 Years
13 Years
ALL
Yes
Sponsors
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American Occupational Therapy Foundation
OTHER
Nationwide Children's Hospital
OTHER
Ohio State University
OTHER
Responsible Party
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Jewel Crasta
Assistant Professor
Principal Investigators
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Jewel Crasta, PhD., OTR/L
Role: PRINCIPAL_INVESTIGATOR
Ohio State University
Locations
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Nationwide Children's Hospital
Columbus, Ohio, United States
McCampbell Hall
Columbus, Ohio, United States
Countries
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References
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Case-Smith J, Weaver LL, Fristad MA. A systematic review of sensory processing interventions for children with autism spectrum disorders. Autism. 2015 Feb;19(2):133-48. doi: 10.1177/1362361313517762. Epub 2014 Jan 29.
Crasta, J. E. (2018). Behavioral and neural sensory processing in young adults with autism spectrum disorder. American Journal of Occupational Therapy, 72(4_Supplement_1), 7211505081p1. https://doi.org/10.5014/ajot.2018.72S1-PO1012
Dawson G, Jones EJ, Merkle K, Venema K, Lowy R, Faja S, Kamara D, Murias M, Greenson J, Winter J, Smith M, Rogers SJ, Webb SJ. Early behavioral intervention is associated with normalized brain activity in young children with autism. J Am Acad Child Adolesc Psychiatry. 2012 Nov;51(11):1150-9. doi: 10.1016/j.jaac.2012.08.018.
LaGasse AB, Manning RCB, Crasta JE, Gavin WJ, Davies PL. Assessing the Impact of Music Therapy on Sensory Gating and Attention in Children With Autism: A Pilot and Feasibility Study. J Music Ther. 2019 Aug 13;56(3):287-314. doi: 10.1093/jmt/thz008.
Miller LJ, Anzalone ME, Lane SJ, Cermak SA, Osten ET. Concept evolution in sensory integration: a proposed nosology for diagnosis. Am J Occup Ther. 2007 Mar-Apr;61(2):135-40. doi: 10.5014/ajot.61.2.135. No abstract available.
Crasta JE, Gavin WJ, Davies PL. Expanding our understanding of sensory gating in children with autism spectrum disorders. Clin Neurophysiol. 2021 Jan;132(1):180-190. doi: 10.1016/j.clinph.2020.09.020. Epub 2020 Oct 16.
Other Identifiers
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2021H0140
Identifier Type: -
Identifier Source: org_study_id