Study on the Correlation Between Neurotrophic Factors and the Condition of Stroke Patients
NCT ID: NCT05479903
Last Updated: 2022-07-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
300 participants
INTERVENTIONAL
2021-11-16
2024-12-31
Brief Summary
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Neurotrophic factors are diverse, most of which are mainly derived from neuronal cells in the central nervous system and are involved in a variety of neurological functions such as cell growth, differentiation and plasticity, thus promoting recovery of multiple functions after stroke. Many studies have found that different interventions affect the prognosis of stroke patients differently, e.g., long-term acupuncture increases serum levels of brain-derived neurotrophic factor in stroke patients and also has better outcomes than controls in post-stroke neurological recovery and the development of post-stroke psychiatric disorders.
This study investigated the effects of different therapeutic measures on patients' functional recovery and neurotrophic factors by setting up a controlled and blinded trial design, which could not only provide clinical evidence for the effectiveness of relevant therapeutic measures, but also verify the clinical value of certain neurotrophic factors (e.g., predicting outcome, assessing condition, and preventing adverse events).
Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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acupuncture stroke group
acupuncture
Manual acupuncture or electro-acupuncture by experienced acupuncturists for patients
Conventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
sham acupuncture stroke group
Conventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
no acupuncture stroke group
Conventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
acupuncture healthy group
acupuncture
Manual acupuncture or electro-acupuncture by experienced acupuncturists for patients
computerized cognitive training group
computerized cognitive training system
One-on-one cognitive training by an experienced cognitive therapist, combined with an existing computerized cognitive training system
Conventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
tranditional cognitive training group
aerobic exercise
Patients are trained by experienced physical therapists with the help of elastic bands and physical therapy devices
Conventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
aerobics group
tranditional cognitive training
One-on-one cognitive training with an experienced cognitive therapist, combined with traditional cognitive training methods (e.g., balls, cards, counting, daily conversation, etc.)
Conventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
Interventions
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acupuncture
Manual acupuncture or electro-acupuncture by experienced acupuncturists for patients
computerized cognitive training system
One-on-one cognitive training by an experienced cognitive therapist, combined with an existing computerized cognitive training system
aerobic exercise
Patients are trained by experienced physical therapists with the help of elastic bands and physical therapy devices
tranditional cognitive training
One-on-one cognitive training with an experienced cognitive therapist, combined with traditional cognitive training methods (e.g., balls, cards, counting, daily conversation, etc.)
Conventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
Eligibility Criteria
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Inclusion Criteria
* Clear imaging evidence
* Diagnosis of spontaneous cerebral hemorrhage by an immobilized physician according to relevant guidelines; pre-onset mRS score ≤ 1
Exclusion Criteria
* History of previous intracranial surgery
* Previous cerebrovascular accident
* Previous speech disorders and limb movement disorders
* Participation in other trials in the last three months.
18 Years
85 Years
ALL
Yes
Sponsors
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Chongqing Medical University
OTHER
Responsible Party
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Lingcong Li
M.S. in Medicine
Locations
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Yongchuan Hospital of Chongqing Medical University
Chongqing, , China
Countries
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Central Contacts
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Facility Contacts
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Lingcong Li, M.S. in Medicine
Role: primary
Other Identifiers
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2021kelunshen110
Identifier Type: -
Identifier Source: org_study_id