A REAl-life Study on Short-term DAPT in Patients With Ischemic Stroke or TIA
NCT ID: NCT05476081
Last Updated: 2024-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
2239 participants
OBSERVATIONAL
2021-02-03
2023-05-03
Brief Summary
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Detailed Description
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Randomized clinical trials (RCTs) proved that short-term DAPT is superior over single antiplatelet treatment in reducing the ischemic recurrence risk, without a remarkable increased hemorrhagic risk thanks to the short treatment course. However, RCTs excluded patients treated with revascularization procedures (i.e. intravenous thrombolysis and thrombectomy), did not provide data on neuroimaging, and had slightly different treatment procedures such as time-to-DAPT start and antiplatelets loading dose.
The study comprises a baseline coinciding with the index event, when the investigators will collect demographics and characteristics of the event, and a 90±5 day follow-up from the index event, when patients will be screened for treatment compliance, tolerability and ischemic or hemorrhagic events. Follow-up visit can be performed remotely.
The investigators did not establish strict NIHSS or ABCD2 score cutoff for patients' inclusion, as treatment decision has to be taken independently from the study, and highly recommend physicians to adhere to guidelines. Each participating center will include all consecutive patients (hospitalized or non-hospitalized) who will meet inclusion criteria.
Data were entered in an electronic anonymized database created on the Research Electronic Data Capture (REDCap) software for the analyses hosted at University of L'Aquila. The local PI or the co-investigators will be able to upload patients' data through a single form specifically created for the study, which will include a user-friendly drop-down menu. Anonymized data will be stored on a secured server under the responsibility of University of L'Aquila. The data will be automatically backed-up once a week. Data will not be shared with unauthorized persons. Plausibility of the entered data will be checked by the study manager and the statistical data manger and data queries will be resolved by Local PI. Cases with missing data or unresolved queries will be rejected to retain only the highest quality data in the registry. Data from centers not ensuring consecutive recruitment of patients or adequate follow-up will not be included in the final database.
All analyses will be performed according to the intention-to-treat principle in all included patients completing the 90-day follow-up or having a fatal outcome event within 90 days. Descriptive statistics will be used to report baseline information. The investigators will analyze the time from index event to the first occurrence of primary and secondary outcome events with the use of a Cox proportional hazards model. Two statistical models will be used: Model 1 unadjusted and Model 2 adjusted for demographics and characteristics of the index event. P values for interaction will be calculated according to the following subgroups: type of event (ischemic stroke vs TIA), time to DAPT (≤24 hours vs \>24 hours from symptom onset), type of DAPT (aspirin+clopidogrel vs aspirin+ticagrelor), DAPT duration (≤21 vs \>21 days and ≤30 vs \>30 days), NIHSS score at onset (≤3 vs \>3 and ≤5 vs \>5), revascularization procedure (i.v. thrombolysis and/or mechanical thrombectomy vs no interventions). Hazard ratios with 95% confidence intervals will be reported. Should multiple events of the same type occur, the time to the first event will be used in the model. Data from patients who had no events during the study will be censored at the time of study termination or death. Assuming a 95% confidence interval, an estimated sample size of 1067 subjects would be required to detect a conservative 50% proportion of primary outcome occurrence with a two-sided 2.5% margin of error.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients (single cohort study)
Patients presenting with a mild-to-moderate ischemic stroke or high risk TIA
Aspirin
Aspirin (100-300 mg) administered for 21-90 days in combination with another antiplatelet treatment
Clopidogrel
Clopidogrel (75-600 mg) administered for 21-90 days in combination with another antiplatelet treatment
Ticagrelor
Ticagrelor (90-180 mg) administered for 21-90 days in combination with another antiplatelet treatment
Interventions
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Aspirin
Aspirin (100-300 mg) administered for 21-90 days in combination with another antiplatelet treatment
Clopidogrel
Clopidogrel (75-600 mg) administered for 21-90 days in combination with another antiplatelet treatment
Ticagrelor
Ticagrelor (90-180 mg) administered for 21-90 days in combination with another antiplatelet treatment
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Male or female aged \>18 years;
* Providing signed and dated informed consent;
* Willing to comply with all study procedures and to be available for the duration of the study.
Exclusion Criteria
* Patients participating to any interventional RCT on stroke prevention;
* Presence of any condition which may preclude reliability of the collected information
18 Years
ALL
No
Sponsors
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University of L'Aquila
OTHER
Responsible Party
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Simona Sacco
Professor
Principal Investigators
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Simona Sacco, MD
Role: STUDY_CHAIR
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila
Locations
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Neurology e Stroke Unit Departement, SS Filippo e Nicola Hospital
Avezzano, Abruzzo, Italy
Department of Neurology and Stroke Unit, Ente Ecclesiastico ospedale Generale Regionale Miulli
Acquaviva delle Fonti, , Italy
Department f Neurology, AO Nazionale SS Biagio and Cesare Arrigo
Alessandria, , Italy
Department of Neurology, Murgia Hospital Fabio Perinei SS 96
Altamura, , Italy
Department of Neurology and Stroke Unit Ospedali Riuniti Ancona
Ancona, , Italy
Department of Neurology, INRCA-IRCCS "U Sestili" Hospital
Ancona, , Italy
Department of Neurology and Stroke Unit, "U. Parini" Hospital
Aosta, , Italy
Department of Neurology, San Donato Hospital, Azienda USL Toscana Sud Est, Arezzo e Val D'Arno
Arezzo, , Italy
Department of Neurology and Stroke Unit, "Di Venere" Hospital
Bari, , Italy
Stroke Unit, Policlinico di Bari, Giovanni XXIII Hospital
Bari, , Italy
Department of Neurology and Stroke Unit, "Mons. Dimiccoli" Hospital
Barletta, , Italy
Department of Neurology,San Bassiano Hospital
Bassano del Grappa, , Italy
Stroke Unit, San Martino di Belluno Hospital ULSS 1
Belluno, , Italy
Department of Neurology, AO San Pio
Benevento, , Italy
Department of Neurology and Stroke Unit, Maggiore Hospital, IRCCS Istituto delle Scienze Neurologiche di Bologna
Bologna, , Italy
Department of Neurology, Policlinico S. Orsola-Malpighi-Clinica Neurologica Metropolitana, IRCCS Istituto delle Scienze Neurologiche di Bologna
Bologna, , Italy
Stroke Center, Gubbio-Gualdo Tadino Hospital
Branca, , Italy
Neuro-vascular Unit, AO Spedali Civili
Brescia, , Italy
Stroke Unit, ASST Franciacorta
Brescia, , Italy
Stroke Unit, Istituto Ospedaliero Fondazione Poliambulanza
Brescia, , Italy
Stroke Unit, A. Perrino Hospital
Brindisi, , Italy
Department of Neurology and Stroke Unit, AO "G. Brotzu"
Cagliari, , Italy
Department of Neurology and Stroke Unit, S Elia Hospital
Caltanissetta, , Italy
Stroke Unit, AO San Sebastiano AORN Caserta
Caserta, , Italy
Department of Neurology, San Giacomo Hospital
Castelfranco Veneto, , Italy
Department of Neurology, AO Cannizzaro
Catania, , Italy
Department of Neurology, Institute G. Giglio di Cefalù
Cefalù, , Italy
Department of Neurology and Stroke Unit, "Bufalini" Hospital
Cesena, , Italy
Department of Neurology and Stroke Unit, SS Annunziata Hospital
Chieti, , Italy
Department of Neurology and Stroke Unit, Cittadella, AULSS6 Euganea
Cittadella, , Italy
Stroke Center, USL umbria 1
Città di Castello, , Italy
Stroke Unit, Valduce Hospital
Como, , Italy
Department of Neurology, Conegliano Hospital Aulss 2 Veneto
Conegliano, , Italy
Department of Neurology and Stroke Unit, ASST Maggiore Hospital of Crema
Crema, , Italy
Department of Neurology, ASST Cremona
Cremona, , Italy
Department of Neurology, Santa Croce Hospital
Cuneo, , Italy
Department of Neurology and Stroke Unit, Desio Hospital ASST Monza
Desio, , Italy
Department of Neurology, ASUR Area Vasta 4 (ex ZT11)
Fermo, , Italy
Department of NeurologY, AOU of Ferrara
Ferrara, , Italy
Department of Neurology, San Giovanni di Dio Hospital
Florence, , Italy
Stroke Unit, AOU Careggi
Florence, , Italy
Department of Neurology, Ente Ospedali Galliera Genova
Genova, , Italy
Stroke Unit, San Martino Hospital of Genova
Genova, , Italy
Department of Neurology, ASUGI
Gorizia, , Italy
Department of Neurology, USL Toscana sud est
Grosseto, , Italy
Department of Neurology and Stroke Unit, ASUR Marche AV2 Jesi
Iesi, , Italy
Department of Neuology, Sant'Andrea Hospital, Azienda Sanitaria Locale n. 5 "Spezzino" La Spezia
La Spezia, , Italy
Department of Neurology, F Renzetti Hospital
Lanciano, , Italy
UTN, Santa Maria Goretti Hospital
Latina, , Italy
Department of Neurology, Ospedale Vito Fazi
Lecce, , Italy
Department of Neurology, Legnago Hospital
Legnago, , Italy
Department of Neurology and Stroke Unit Ospedale of Legnano
Legnano, , Italy
Emergency Department, Azienda USL 6 Livorno
Livorno, , Italy
Department of Neurology, Valle del Serchio Hospital
Lucca, , Italy
Departement of Neurology, San Salvatore Hospital
L’Aquila, , Italy
Department of Neurology, Apuane Hospital, Azienda USL Toscana Nord Ovest
Massa, , Italy
Department of Neurology, ASST Melegnano e della Martesana
Melegnano, , Italy
Department of Neurology, ASST Merate
Merate, , Italy
Stroke Unit, AOU Gaetano Martino
Messina, , Italy
Stroke Unit, Angelo's Hospital
Mestre, , Italy
Stroke Unit, Istituto Clinico Città Studi
Milan, , Italy
Department of Neurology and Stroke Unit, Humanitas
Milan, , Italy
Department of Neurology and Stroke Unit, IRCCS Istituto Auxologico Italiano, San Luca Hospital
Milan, , Italy
Department of Neurology, Mirano ULSS 3 Serenissima
Mirano, , Italy
Stroke Unit, "S.Agostino-Estense" Hospital, AOU of Modena
Modena, , Italy
Stroke Unit, Santa Croce Hospital
Moncalieri, , Italy
Department of Neurology, San Gerardo Hospital and Bicocca University
Monza, , Italy
Department of Neurology and Stroke Unit, Cardarelli Hospital
Napoli, , Italy
Stroke Unit, Ospedale del Mare
Napoli, , Italy
Department of Neurology and Stroke Unit, AOU Maggiore della Carità
Novara, , Italy
Stroke Unit, San Giacomo Hospital
Novi Ligure, , Italy
Stroke Unit, AOU San Luigi Gonzaga
Orbassano, , Italy
Stroke Unit, Azienda Ospedale Università
Padua, , Italy
Department of Neurology and Stroke Unit, ARNAS Civico of Palermo
Palermo, , Italy
Department of Neurology, Villa Sofia Hospital
Palermo, , Italy
Department of Neurophysiopathology and Stroke Unit, AOUP Paolo Giaccone
Palermo, , Italy
Stroke Unit, Buccheri La Ferla Hospital
Palermo, , Italy
Department of neurology, Azienda Ospedaliero-Universitario di Parma
Parma, , Italy
Stroke Unit, Fidenza AUSL PR
Parma, , Italy
Cerebrovascula disease and Stroke Unit neurological Intitute IRCCS Mondino
Pavia, , Italy
Stroke Unit, AOUUD Santa Maria della Misericordia
Perugia, , Italy
Department of Neurology ande Stroke Unit, Pescara Hospital
Pescara, , Italy
Stroke Unit, Pederzoli Hospital
Peschiera del Garda, , Italy
Department of Neurology, AUSL Piacenza
Piacenza, , Italy
Departement of Neurology and Stroke Center, S.Corona Hospital
Pietra Ligure, , Italy
Department of Neurology and Stroke Unit, E. Agnelli Hospital
Pinerolo, , Italy
Department of Neurology, Azienda ospedaliera e universitaria Pisana
Pisa, , Italy
Department of Neurology, San Jacopo Hospital
Pistoia, , Italy
Stroke Unit, AO"San Carlo"
Potenza, , Italy
Department of Neurology, Maria Paternò Arezzo Hospital
Ragusa, , Italy
Department of Neurology and Stroke Unit, Santa Maria delle Croci Hospital
Ravenna, , Italy
Stroke Unit, AO "Bianchi-Melacrino-Morelli"
Reggio Calabria, , Italy
Department of Neurology and Stroke Unit, Arcispedale Santa Maria Nuova
Reggio Emilia, , Italy
Department of Neurology, Infermi di Rimini Hospital
Rimini, , Italy
Unità di trattamento neurovascolare, Azienda Ospedaliero Universitaria Policlinico Umberto I
Roma, , Italy
Department of Neurology and Stroke Unit, Sant'Eugenio Hospital
Rome, , Italy
Department of Neurology and Stroke Unit, Systems Medicin, Policlinico Tor Vergata
Rome, , Italy
Department of Neurology, Ospedale Fatebenefratelli
Rome, , Italy
Department of Neurology, Policlinico Gemelli
Rome, , Italy
Department of Neurology, SS Filippo Neri Hospital
Rome, , Italy
Stroke Unit, AO San Camillo
Rome, , Italy
Stroke Unit, AOU Sant'Andrea
Rome, , Italy
Stroke Unit, Ospedale Rovigo, ULSS 18
Rovigo, , Italy
Department of Neurology, Presidio ospedaliero Umberto I Nocera Inferiore
Salerno, , Italy
Department of Neurology, Madonna del Soccorso Hospital
San Benedetto del Tronto, , Italy
Department of Neurology, ASST Lariana, Sant'Anna Hospital
San Fermo della Battaglia, , Italy
Department of Neurology, Casa sollievo della sofferenza
San Giovanni Rotondo, , Italy
Stroke Unit, AOU
Sassari, , Italy
Department of Neurology, SS. Annunziata Hospital
Savigliano, , Italy
Stroke Unit, Azienda ospedaliera universitaria Senese
Siena, , Italy
Department of Neurology, SS Annunziata Hospital
Sulmona, , Italy
Department of Neurology and Stroke Unit, Umberto I Hospital
Syracuse, , Italy
Department of Neurology and Stroke Unit, AO Santa Maria of Terni
Terni, , Italy
Department of Neurology and Stroke Unit, San Giovanni Bosco Hospital
Torino, , Italy
Neuro-vascular Unit, Maria Vittoria Hospital
Torino, , Italy
Department of Neurology and Stroke Unit, ASP of Trapani
Trapani, , Italy
Stroke Unit, Santa Chiara Hospital
Trento, , Italy
Department of Neurology, Cà Foncello Hospital
Treviso, , Italy
Department of Neurology, Azienda Ospedaliera-Universitaria Giuliano Isontina
Trieste, , Italy
Department of Neurology and Rehabilitation, ASUR
Udine, , Italy
Department of Neurology and Stroke Unit, ASST Settelaghi
Varese, , Italy
Department of Neurology, SS Giovanni e Paolo Hospital, Aulss3 Serenissima Veneto
Venezia, , Italy
Department of Neurology, Sant'Andrea Hospital
Vercelli, , Italy
Department of Neurology and Stroke Unit, Arzignano Azienda ULSS 8 Berica
Vicenza, , Italy
Department of Neurology and Stroke Unit, San Bortolo Hospital
Vicenza, , Italy
Stroke Unit, ASST Vimercate
Vimercate, , Italy
Department of Neurology and Stroke Unit, Guzzardi Hospital
Vittoria, , Italy
Countries
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References
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Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC; CHANCE Investigators. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013 Jul 4;369(1):11-9. doi: 10.1056/NEJMoa1215340. Epub 2013 Jun 26.
Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM; FASTER Investigators. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol. 2007 Nov;6(11):961-9. doi: 10.1016/S1474-4422(07)70250-8. Epub 2007 Oct 10.
Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med. 2018 Jul 19;379(3):215-225. doi: 10.1056/NEJMoa1800410. Epub 2018 May 16.
Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. N Engl J Med. 2020 Jul 16;383(3):207-217. doi: 10.1056/NEJMoa1916870.
De Santis F, Ornello R, De Matteis E, D'Anna L, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Diomedi M, Bagnato MR, Petruzzellis M, Mezzapesa DM, Inchingolo V, Cappellari M, Zivelonghi C, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Piscaglia MG, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Papiri G, Viticchi G, Orsucci D, Falcou A, Beretta S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, De Michele M, Ricci S, Sacco S, Foschi M. Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched analysis. Ther Adv Neurol Disord. 2025 Jul 12;18:17562864251351100. doi: 10.1177/17562864251351100. eCollection 2025.
De Matteis E, De Santis F, Foschi M, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Maestrini I, Bagnato MR, Petruzzellis M, Mezzapesa DM, Di Viesti P, Inchingolo V, Cappellari M, Zenorini M, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Moraru S, Piscaglia MG, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Paci C, Viticchi G, Orsucci D, Falcou A, Diamanti S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Manobianca G, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, Toni D, Ricci S, Sacco S, Ornello R; READAPT Study Group. Real-World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis-Insights From the READAPT Study. Eur J Neurol. 2025 Apr;32(4):e70163. doi: 10.1111/ene.70163.
Foschi M, D'Anna L, De Matteis E, De Santis F, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Diomedi M, Bagnato MR, Petruzzellis M, Mezzapesa DM, Di Viesti P, Inchingolo V, Cappellari M, Zivelonghi C, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Moraru S, Piscaglia MG, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Papiri G, Paci C, Viticchi G, Orsucci D, Falcou A, Beretta S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Manobianca G, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, De Michele M, Ricci S, Ornello R, Sacco S; READAPT Study Group. Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort. Stroke. 2025 Feb;56(2):305-317. doi: 10.1161/STROKEAHA.124.049210. Epub 2024 Dec 9.
Ornello R, Foschi M, De Santis F, Romoli M, Tassinari T, Saia V, Cenciarelli S, Bedetti C, Padiglioni C, Censori B, Puglisi V, Vinciguerra L, Guarino M, Barone V, Zedde M, Grisendi I, Diomedi M, Bagnato MR, Petruzzellis M, Mezzapesa DM, Di Viesti P, Inchingolo V, Cappellari M, Zivelonghi C, Candelaresi P, Andreone V, Rinaldi G, Bavaro A, Cavallini A, Moraru S, Querzani P, Terruso V, Mannino M, Pezzini A, Frisullo G, Muscia F, Paciaroni M, Mosconi MG, Zini A, Leone R, Palmieri C, Cupini LM, Marcon M, Tassi R, Sanzaro E, Paci C, Viticchi G, Orsucci D, Falcou A, Beretta S, Tarletti R, Nencini P, Rota E, Sepe FN, Ferrandi D, Caputi L, Volpi G, La Spada S, Beccia M, Rinaldi C, Mastrangelo V, Di Blasio F, Invernizzi P, Pelliccioni G, De Angelis MV, Bonanni L, Ruzza G, Caggia EA, Russo M, Tonon A, Acciarri MC, Anticoli S, Roberti C, Manobianca G, Scaglione G, Pistoia F, Fortini A, De Boni A, Sanna A, Chiti A, Barbarini L, Caggiula M, Masato M, Del Sette M, Passarelli F, Bongioanni MR, Toni D, Ricci S, De Matteis E, Sacco S; READAPT Study Group. Combining Intravenous Thrombolysis and Dual Antiplatelet Treatment in Patients With Minor Ischemic Stroke: A Propensity Matched Analysis of the READAPT Study Cohort. J Am Heart Assoc. 2024 Aug 20;13(16):e036275. doi: 10.1161/JAHA.124.036275. Epub 2024 Aug 9.
De Matteis E, De Santis F, Ornello R, Censori B, Puglisi V, Vinciguerra L, Giossi A, Di Viesti P, Inchingolo V, Fratta GM, Diomedi M, Bagnato MR, Cenciarelli S, Bedetti C, Padiglioni C, Tassinari T, Saia V, Russo A, Petruzzellis M, Mezzapesa DM, Caccamo M, Rinaldi G, Bavaro A, Paciaroni M, Mosconi MG, Foschi M, Querzani P, Muscia F, Gallo Cassarino S, Candelaresi P, De Mase A, Guarino M, Cupini LM, Sanzaro E, Zini A, La Spada S, Palmieri C, Sepe FN, Beretta S, Paci C, Caggia EA, De Angelis MV, Bonanni L, Volpi G, Tassi R, Pistoia F, Scoditti U, Tonon A, Viticchi G, Ruzza G, Nencini P, Cavallini A, Toni D, Ricci S, Sacco S; READAPT Study Group. Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke. Stroke. 2023 May;54(5):1172-1181. doi: 10.1161/STROKEAHA.122.041660. Epub 2023 Mar 23.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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03/2021
Identifier Type: -
Identifier Source: org_study_id