Minocycline for Chronic Autoimmune Uveitis

NCT ID: NCT05474729

Last Updated: 2023-04-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE1/PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-01

Study Completion Date

2026-12-31

Brief Summary

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Autoimmune uveitis is one kind of non-infectious, sight-threatening, relapsing and severe ocular disease. Approximately 20%-25% autoimmune uveitis patients suffer from the dilemma of blindness for the chronic and persistent inflammatory state in the eyes, which results in continuous destroy in the structure of the eyes and gradually leads to irreversible damage on visual function. However, it shows limiting efficacy of current treatment including glucocorticoids, immunosuppressant and biologics for chronic autoimmune uveitis. Minocycline has been regarded to have anti-apoptosis and immunemodulatory function for decades and it has been illustrated to be beneficial in several neuro-degenerative and neuro-inflammatory diseases. This trial aims to investigate the efficacy and safety of minocycline for chronic autoimmune uveitis with retinal degenerative changes.

Detailed Description

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Conditions

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Minocycline Uveitis Retinal Degeneration

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

minocycline capsule
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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minocycline

minocycline capsule 100mg per day orally

Group Type EXPERIMENTAL

minocycline

Intervention Type DRUG

minocycline capsule 100mg per day orally

Interventions

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minocycline

minocycline capsule 100mg per day orally

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Participant diagnosed of autoimmune diseases with visual function damage (decrease of BCVA, loss of retinal structure)
* Participant aged from 18-60 years old.
* Participant that signed the informed consent document and is able to complete the following visits.

Exclusion Criteria

* Participant is allergy to minocycline or tetracyclines.
* Participant has no contraindications of minocycline or tetracyclines.
* Participant has an abnormal function of liver, heart, kidney and thyroid.
* Participant is using glucocorticoids, immunosuppressants or biologics.
* Female that is pregnant, breast-feeding or planning to become pregnant.
* Participant that is currently using other medications for other diseases.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Dan Liang

Dan Liang, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dan Liang

Role: PRINCIPAL_INVESTIGATOR

Zhongshan Ophthalmic Center, Sun Yat-sen University

Locations

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Zhongshan Ophthalmic Center

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Dan Liang

Role: CONTACT

(86)-87330402

Yuxi Chen

Role: CONTACT

(86)-87330402

Facility Contacts

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Dan Liang

Role: primary

(86)-87330402

Other Identifiers

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MINOCU

Identifier Type: -

Identifier Source: org_study_id

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