Impact of Olfactory Odour StimulatioN on Energy EXpenditure
NCT ID: NCT05472168
Last Updated: 2023-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
58 participants
INTERVENTIONAL
2022-01-18
2024-10-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
SINGLE
Study Groups
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Obese
Age 18-55 years Obesity (BMI ≥30 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test)
Olfactory Stimulation
Participants are exposed to different odours and energy expenditure is assessed via indirect calorimetry.
Lean
Age 18-55 years Lean (BMI 18-25 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test)
Olfactory Stimulation
Participants are exposed to different odours and energy expenditure is assessed via indirect calorimetry.
Interventions
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Olfactory Stimulation
Participants are exposed to different odours and energy expenditure is assessed via indirect calorimetry.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Obesity (BMI ≥30 kg/m2) and Lean (BMI 18-25 kg/m2)
* Written informed consent
* Normosmia (defined by sniffing Sticks test)
Exclusion Criteria
* Surgical intervention of the nasal cavity or the paranasal sinus
* Known allergy to odors used in the study
* Smokers
* Current illicit drug abuse including daily marijuana and cannabidiol (CBD) consumption (alcohol ≤2 drinks per day allowed)
* Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease)
* Diabetes mellitus
* Treatment with insulin sensitizing drugs including Glucagon-like Peptide (GLP)-1 analogues within the last 3 months
* History of neurodegenerative diseases, severe head trauma
* Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2)
* Known liver cirrhosis or other severe liver impairment
* Use of any kind of decongestant more than twice a week
* Use of cortisone-containing nasal spray within the last 3 months
* Acute upper respiratory tract infection
* Uncontrolled dysthyroidism
* Uncontrolled hypertension
* Regular use of psychopharmaceutic drugs
* Study participants aims to start a new diet or exercise program during the study
* Bariatric surgery
* Pregnancy/Lactation
* Onset of climacteric symptoms within one year (e.g. hot flashes and/or diaphoresis) OR initiation of hormonal replacement therapy in the last three months
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
* Participation in an interventional study within the last 3 months
18 Years
55 Years
ALL
Yes
Sponsors
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University Hospital, Basel, Switzerland
OTHER
Responsible Party
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Katharina Timper
Principal Investigator, Prof. Dr. med.
Locations
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University Hospital Basel
Basel, , Switzerland
Countries
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Facility Contacts
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Katharina Timper, Prof.Dr.med.
Role: primary
Anouk Hoogkamer
Role: backup
Other Identifiers
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Timper_Olfactory_2022
Identifier Type: -
Identifier Source: org_study_id