Neoadjuvant Anti-PD1 in HCC

NCT ID: NCT05471674

Last Updated: 2023-02-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-07-03
• Study Completion Date: 2022-12-31

Brief Summary

This is a phase 2, single-arm trial designed to assess the clinical benefit of treatment with nivolumab administered in patients with untreated, borderline resectable HCC.

Conditions

Hepatocellular Carcinoma; HCC; Liver Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment

Group Type: EXPERIMENTAL

Nivolumab

Intervention Type: DRUG

3 mg/kg on Day 1 of each 2-weekly cycle for 3 doses

Hepatectomy

Intervention Type: PROCEDURE

Hepatectomy will be performed approximately 2 weeks after the 3rd dose of nivolumab

Interventions

Nivolumab

3 mg/kg on Day 1 of each 2-weekly cycle for 3 doses

Intervention Type: DRUG

Hepatectomy

Hepatectomy will be performed approximately 2 weeks after the 3rd dose of nivolumab

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Signed written informed consent form prior to the screening procedures.

2. Age ≥ 18 years.

3. Histological proof of HCC.

4. Willingness to undergo a pre-dosing fresh tumour biopsy. Patients for whom fresh biopsy may not be feasible will be ineligible for enrollment.

5. Intermediate or locally-advanced HCC (according to HKLC tumour status categorization) with the option of resection for potential cure as assessed by surgeon.

6. Child-Pugh score ≤ 7 with no symptomatic ascites or ascites requiring therapeutic paracentesis.

7. ECOG performance status ≤ 1.

8. Life expectancy of ≥ 12 weeks.

9. Adequate organ function (blood transfusion or use of biologic response modifiers is not permitted).

10. Measurable disease according to RECIST v1.1.

11. Women of childbearing potential (WOCBP) must agree to follow instructions for method(s) of contraception.

12. Males who are sexually active with WOCBP must agree to follow instructions for method(s) of contraception.

13. Able and willing to meet all protocol-required treatments, investigations and visits.

Exclusion Criteria

1. Patients who have history of organ transplantation.

2. History of allergy or hypersensitivity to study drug components.

3. Patients who have active, known or suspected autoimmune disease. Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition adequately treated with hormonal replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger or deemed by the investigator not to affect safety assessment.

4. Patients with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days prior to start of study treatment. Inhaled or topical steroids, and adrenal replacement steroid doses > 10 mg daily prednisone equivalent, are permitted in the absence of active autoimmune disease.

5. Patients who have received prior therapy with an anti-PD-1, anti-PD-L1, anti-PDL-2, or anti-CTLA-4 antibody (or any other antibody targeting T cell co-regulatory pathways).

6. Receipt of any cancer therapy in the pre-operative period.

7. Treatment with botanical preparations (e.g., herbal supplements or traditional Chinese medicine) intended for general health support or to treat the disease under study within 2 weeks prior to treatment.

8. Active, acute, or chronic clinically significant infections requiring therapy with the exception of hepatitis B or C virus infection. Patients with chronic HBV infection must be on antiviral therapy and have HBV DNA < 500 IU/ml. Active or chronic co-infection with hepatitis B and C, or hepatitis B and D is not allowed.

9. Known history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).

10. Symptomatic congestive heart failure, defined as ≥ Class II of the New York Heart Association functional classification system or known LVEF < 50% at baseline.

11. Active angina pectoris or recent myocardial infarction (within 6 months).

12. Chronic atrial fibrillation or QTcF > 470 msec.

13. History of other previous cancer that would interfere with the determination of safety or efficacy of nivolumab with respect to HCC.

14. Women who are pregnant or breast-feeding.

15. Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of study results.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Dr Tan-to CHEUNG

OTHER

Sponsor Role: lead

Responsible Party

Dr Tan-to CHEUNG

Clinical Associate Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Tan-to Cheung, MD

Role: PRINCIPAL_INVESTIGATOR

The University of Hong Kong

Locations

Queen Mary Hospital

Hong Kong, , Hong Kong

Countries

Hong Kong

Related Links

http://www.hkuctr.com/Study/Show/1aa3c360332c4a72abe5db565b152349

HKU Clinical Trials Registry record

Other Identifiers

CA209-7KU

Identifier Type: -

Identifier Source: org_study_id