Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment

NCT ID: NCT05460507

Last Updated: 2025-03-30

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-12-12
• Study Completion Date: 2028-03-01

Brief Summary

This is an open-label, multicenter, Phase 1 study to establish the safety and efficacy/tolerability of a single dose of 186RNL by the intraventricular route (via intraventricular catheter) for recurrence glioma in patients who received a prior treatment of 186RNL.

Detailed Description

This Phase I clinical study evaluates a single dose of 186RNL (radionuclide clinical study drug) administered through a convection enhanced delivery catheter (CED catheter) in participants who have already received a prior treatment of 186RNL.

The clinical study treatment consists of a single administered dose of 186RNL per participant. The proposed dose is up to 8.8 mL as a single administration with an administered dose of 22.3 mCi.

An estimated number of participants to be enrolled in the study is approximately 40.

The clinical study treatment will be administered, following CED placement, by the clinical study physician.

Post-treatment evaluations will be done at Days 3, 7, 14, 28, and every subsequent 28-day interval thereafter until disease progression is confirmed and all treatment related toxicities are resolved. The minimum assessment period for toxicities is 12 weeks.

The U.S. Food and Drug Administration (FDA) has not approved 186RNL for this specific disease.

Conditions

Glioma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Retreatment with Rhenium Liposome

Each participant will receive a single administration of 186RNL. The proposed dose is up to 8.8 mL as a single administration with an administered dose of 22.3 mCi.

Group Type: EXPERIMENTAL

Retreatment Rhenium Liposome

Intervention Type: DRUG

At the time of stereotactic biopsy a catheter will be placed within the tumor using stereotactic guidance. Once the patient has adequately recovered from the procedure as determined by the neurosurgeon, 186RNL will be infused through the CED catheter at the predetermined dose. Spectroscopic imaging will then be obtained at predefined time points to visualize the distribution of the 186RNL as well as calculated the actual dose retained within the tumor. Patients will be monitored longitudinally for evidence of toxicity and response by MRI.

Interventions

Retreatment Rhenium Liposome

At the time of stereotactic biopsy a catheter will be placed within the tumor using stereotactic guidance. Once the patient has adequately recovered from the procedure as determined by the neurosurgeon, 186RNL will be infused through the CED catheter at the predetermined dose. Spectroscopic imaging will then be obtained at predefined time points to visualize the distribution of the 186RNL as well as calculated the actual dose retained within the tumor. Patients will be monitored longitudinally for evidence of toxicity and response by MRI.

Intervention Type: DRUG

Other Intervention Names

Rhenium-186 NanoLiposome

Eligibility Criteria

Inclusion Criteria

1. At least 18 years of age at time of screening.

2. Ability to understand the purposes and risks of the study and has signed a written informed consent document approved by the site-specific IRB.

3. Patient must present with biopsy and histology proven glioma following initial treatment with 186RNL. The type and grade of glioma to follow the 2021 WHO Classification of Tumors of the Central Nervous System, allowing Grade III and IV gliomas.

4. At least 90 days from prior dose of 186RNL at time of screening.

5. Patients who receive treatment with antiepileptic medications must have a two-week history of stable dose of antiepileptic without seizures prior to dosing.

6. Patients with corticosteroid requirements to control cerebral edema must be maintained at a stable or decreasing dose for a minimum of two weeks without progression of clinical symptoms.

7. A volume of enhancing tumor which falls within the treatment field volume being evaluated in the respective cohort (see 4.1 Design).

8. ECOG performance status of 0 to 2; ECOG 3 acceptable if Principal Investigator and treating physician confirm in patient's interest in study/re-treatment.

9. Life expectancy of at least 2 months

10. Acceptable liver function: Bilirubin ≤ 1.5 times upper limit of normal and AST (SGOT) and ALT (SGPT) ≤ 3.0 times upper limit of normal (ULN)

11. Acceptable renal function: Serum creatinine ≤1.5xULN

12. Acceptable hematologic status (without hematologic support): ANC ≥1000 cells/uL, Platelet count ≥100,000/uL if no bleeding, Hemoglobin ≥7.0 g/dL. Given the absence of hematological toxicity in the ongoing recurrent glioblastoma trial (#12-02) and the need for CED catheter placement, the Investigator and Sub-investigator (neurosurgeon) placing the CED catheter may determine that it is in the patient's best interest and acceptably safe to proceed with this criteria with hematological support or, if no bleeding, Platelet count ≥75,000/uL without support, ANC 1000 cells/uL and Hemoglobin ≥7.0 g/dL

13. All women of childbearing potential must have a negative serum pregnancy test at screening. Male and female subjects must agree to use effective means of contraception (for example, surgical sterilization or the use of barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel or an IUD) with their partner from entry into the study through 6 months after the last dose.

14. Patients must have malignant glioma that has progressed on or after standard treatment (surgery, radiotherapy, and/or chemotherapy) and are planned to undergo stereotactic biopsy as per standard of care.

Exclusion Criteria

1. The subject has evidence of acute intracranial or intratumoral hemorrhage either by MRI or computerized tomography (CT) scan. Subjects with resolving hemorrhage changes, punctate hemorrhage, or hemosiderin are eligible.

2. The subject has contraindications to CNS Magnetic Resonance Imaging (MRI).

3. The subject has not recovered to National Cancer Institute (NCI) Common Terminology Criteria for any prior Adverse Events (CTCAE) v4.0 Grade ≤ 1 from AEs (except alopecia, anemia and lymphopenia) due to antineoplastic agents, investigational drugs, or other medications that were administered prior to study.

4. The subject is pregnant or breast-feeding.

5. The subject has serious intercurrent illness, as determined by the treating physician, which would compromise either patient safety include:

1. Uncontrolled hypertension (two or more blood pressure readings performed at screening of > 150 mmHg systolic or > 100 mmHg diastolic) despite optimal treatment

2. non-healing wound, ulcer, or bone fracture

3. clinically significant cardiac arrhythmias affecting cardiac function

4. untreated hypothyroidism

5. uncontrolled systemic infection

6. symptomatic congestive heart failure or unstable, untreated angina pectoris within 3 months prior study drug

7. myocardial infarction, stroke, transient ischemic attack within 6 months

8. known active malignancy (other than glioma) except non-melanoma skin cancer or carcinoma in-situ in the cervix

6. The subject has an inherited bleeding diathesis or coagulopathy with the risk of bleeding.

7. The subject has received any of the following prior anticancer therapy:

1. Non-standard radiation therapy such as brachytherapy, systemic radioisotope therapy, or intra-operative radiotherapy (IORT) to the target site.

2. Other CNS radiation therapy within 12 weeks of screening.

3. Systemic therapy (including investigational agents and small-molecule kinase inhibitors) or non-cytotoxic hormonal therapy (e.g., tamoxifen) within 14 days or 5 half-lives, whichever is shorter, prior first dose of study drug

4. Biologic agents (antibodies, immune modulators, vaccines, cytokines) within 21 days prior to first dose of study drug

5. Nitrosoureas or mitomycin C within 42 days, or metronomic/protracted low-dose chemotherapy within 14 days, or other cytotoxic chemotherapy within 28 days, prior to first dose of study drug

6. Prior CNS treatment with carmustine wafers

7. Patients who are currently receiving any other investigational agents and/or who have received an investigational agent in the prior 28 days from screening.

8. Patient actively enrolled in an ongoing investigational drug or device trial excluding follow-up only in a previously trial.

8. Multifocal progression or involvement of the leptomeninges.

9. Psychiatric illness/social situations that would limit compliance with the study requirements.

10. Infratentorial disease unless Investigator and neurosurgeon agree it is treated disease.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Plus Therapeutics

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Andrew J Brenner, PhD

Role: PRINCIPAL_INVESTIGATOR

The Cancer Therapy and Research Center at UTHSCSA

Locations

The Cancer Therapy and Research Center at UTHSCSA

San Antonio, Texas, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Rachael Hershey

Role: CONTACT

patients@respect-trials.com

1(210) 791-8723

Andrew Brenner, PhD

Role: CONTACT

patients@respect-trials.com

1(210) 791-8723

Facility Contacts

Leticia Velten, RN

Role: primary

velten@uthscsa.edu

210-450-1921

Other Identifiers

2021-GB-001

Identifier Type: -

Identifier Source: org_study_id