MultiMorbidity Life-Course Approach To Myocardial Health -A Cardiac Sub-Study of the MRC National Survey of Health and Development (NSHD)
NCT ID: NCT05455125
Last Updated: 2022-07-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
550 participants
OBSERVATIONAL
2020-07-01
2024-06-30
Brief Summary
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Methods and expected results The investigators aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR). Through comprehensive myocardial tissue characterization and 4-dimensional flow the investigators hope to better understand the burden of clinical and subclinical cardiovascular disease. Supercomputers will be used to combine the multi-scale ECGI and CMR datasets per participant. Rarely available, prospectively collected whole-of-life data on exposures, traditional risk factors and multimorbidity will be studied to identify risk trajectories, critical change periods, mediators and cumulative impacts on the myocardium.
Conclusion By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR-ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to transform our understanding of how early, mid and later-life risk factor trajectories interact to determine the state of cardiovascular health in older age.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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CMR CGI
High resolution ECGI plus advanced CMR
Eligibility Criteria
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Inclusion Criteria
* Who is still alive and agreed to take part in the study.
Exclusion Criteria
* Implantable cardio defibrillator.
* Atrial fibrillation.
* Complete heart block.
* Severe asthma.
ALL
No
Sponsors
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University College, London
OTHER
Responsible Party
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Locations
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UCL Bloomsbury Centre for Clinical Phenotyping
London, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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References
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Webber M, Joy G, Bennett J, Chan F, Falconer D, Shiwani H, Davies RH, Krausz G, Tanackovic S, Guger C, Gonzalez P, Martin E, Wong A, Rapala A, Direk K, Kellman P, Pierce I, Rudy Y, Vijayakumar R, Chaturvedi N, Hughes AD, Moon JC, Lambiase PD, Tao X, Koncar V, Orini M, Captur G. Technical development and feasibility of a reusable vest to integrate cardiovascular magnetic resonance with electrocardiographic imaging. J Cardiovasc Magn Reson. 2023 Dec 4;25(1):73. doi: 10.1186/s12968-023-00980-7.
Other Identifiers
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123172
Identifier Type: -
Identifier Source: org_study_id
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