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CLIC1 in Patients Presenting PD

NCT ID: NCT05446181

Last Updated: 2024-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-27

Study Completion Date

2024-10-30

Brief Summary

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In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Detailed Description

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Conditions

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Hip Fractures Hip Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Old with perioperative delirium

Perioperative delirium

Intervention Type BEHAVIORAL

Perioperative delirium

Hip surgery

Intervention Type PROCEDURE

Orthopedic hip joint surgery under spinal anesthesia

Old without perioperative delirium

Hip surgery

Intervention Type PROCEDURE

Orthopedic hip joint surgery under spinal anesthesia

Interventions

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Perioperative delirium

Perioperative delirium

Intervention Type BEHAVIORAL

Hip surgery

Orthopedic hip joint surgery under spinal anesthesia

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia

Exclusion Criteria

* Patients who are unconscious
* Patients who are unable to communicate
* Alzheimer
* Parkinson Disease
* Conversion to general anesthesia
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hyo-Seok Na

principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Seoul National Univ. Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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B-2109-706-302

Identifier Type: -

Identifier Source: org_study_id