Novel Rapid POC Diagnostics for COVID-19

NCT ID: NCT05438589

Last Updated: 2023-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1283 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-25

Study Completion Date

2023-02-28

Brief Summary

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This is a prospective, multicentre study in which the diagnostic accuracy of multiple Covid-19 Antigen rapid diagnostic tests will be assessed for COVID-19 case detection using prospectively collected nasal swabs and saliva samples from participants suspected to have Covid-19 infection (with or without symptoms). The study will last approximately 9 months.

Detailed Description

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Adult individuals with presumptive Covid-19, either symptomatic or asymptomatic, will be screened for inclusion at 4 different study sites located in Georgia and South Africa.

Enrolled participants will be asked to provide 2 samples: one nasopharyngeal swab that will be utilized for Covid-19 diagnosis by standard PCR and one sample (either nasal swab or saliva) to be used for the new antigen rapid diagnostic test under evaluation. At least 2 different antigen tests will be evaluated to determine sensitivity and specificity: Novel Corona Virus (SARS-CoV-2) Ag Rapid Test Kit (Jiangsu Bioperfectus Technologies) and GeneFinder COVID-19 Ag Rapid test (Osang Healthcare).

The data gathered from this study, could be used as part of the dossier to be submitted to WHO (world health organization) for review.

Conditions

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COVID-19 Respiratory Infection

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* ≥18 years of age
* Presenting to testing locations linked to the clinical sites
* Suspected to have COVID-19 (as per WHO or national guidelines). These include the following groups:

* Individuals with acute onset of any of the following signs or symptoms: fever, cough, general weakness/fatigue, headache, myalgia, sore throat, coryza, dyspnoea, anorexia/nausea/vomiting, diarrhoea, altered mental status (for SYMPTOMATIC group);
* Contacts of confirmed cases of COVID-19
* Individuals residing or working in an area with high risk of transmission of virus
* Individuals residing or travelling to an area with community transmission
* Individuals working in any health care setting, including within health facilities or within the community
* Provided voluntary written consent to participate in this study
* Provided a specimen suitable for testing

Exclusion Criteria

* Individuals unable to cooperate with respiratory sample collection
* Individuals on oxygen therapy
* Recent history of excessive nose bleeds
* Individuals unable to give informed consent
* Hemodynamic instability as determined by the treating physician
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Foundation for Innovative New Diagnostics, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elena Ivanova Reipold, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

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Locations

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National Center for Disease Control

Tbilisi, , Georgia

Site Status

Ezintsha

Johannesburg, , South Africa

Site Status

Countries

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Georgia South Africa

Other Identifiers

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CV008

Identifier Type: -

Identifier Source: org_study_id