Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

NCT ID: NCT05429502

Last Updated: 2025-10-10

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE1
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-27
• Study Completion Date: 2025-02-26

Brief Summary

This is a Phase I/II study to assess the efficacy and safety of ribociclib in combination with topotecan and temozolomide (TOTEM) in pediatric patients with relapsed or refractory (r/r) neuroblastoma (NB), and other solid tumors, including medulloblastoma (MB), high-grade glioma (HGG), malignant rhabdoid tumors (MRT), and rhabdomyosarcoma (RMS).

Detailed Description

The study is structured into two parts: Phase I - Part A (dose finding) and Phase I - Part B (multiple expansion cohorts). Phase II may commence following the evaluation of Phase I data, which includes safety, tolerability, efficacy, pharmacokinetics, and biomarker data. Additionally, other emerging data that could influence the treatment landscape will be considered before initiating Phase II in patients with relapsed or refractory neuroblastoma (NB) and/or other tumors studied in Phase I.

• Phase I - Part A (dose finding): This phase aims to determine the maximum tolerated dose (MTD) and/or the recommended Phase II dose (RP2D) of ribociclib in combination with TOTEM.

Due to the early termination of the trial, Phase I - Part B (multiple expansion cohorts) and Phase II (double-blind, randomized, placebo-controlled in relapsed or refractory NB) were not initiated.

Conditions

Neuroblastoma

Study Design

• Allocation Method: NA
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Phase I-part A: Ribociclib + Topotecan and Temozolomide

Participants with r/r NB, MB, HGG, MRT or RMS will be treated with ribociclib in combination with topotecan and temozolomide to determine MTD and/or RP2D. Ribociclib dose will be escalated with topotecan and temozolomide.

Group Type: EXPERIMENTAL

Topotecan

Intervention Type: DRUG

Starting out dose of topotecan administered at standard dose given to neuroblastoma patients (0.75 mg/m2/day).

Temozolomide

Intervention Type: DRUG

Starting out dose of temozolomide for cohort A1 and A2 for Phase 1-Part A: 150mg/m2/day. Starting out dose for subsequent cohorts, Cohort A3 and onwards, in Phase 1-Part A will initiate at 100mg/m2/day.

Ribociclib

Intervention Type: DRUG

Starting out dose of ribociclib for cohort A1 Phase 1-Part A: 200mg/m2/day. Starting out dose for Cohort A2 and A3 was 100mg/m2/day.

Interventions

Topotecan

Starting out dose of topotecan administered at standard dose given to neuroblastoma patients (0.75 mg/m2/day).

Intervention Type: DRUG

Temozolomide

Starting out dose of temozolomide for cohort A1 and A2 for Phase 1-Part A: 150mg/m2/day. Starting out dose for subsequent cohorts, Cohort A3 and onwards, in Phase 1-Part A will initiate at 100mg/m2/day.

Intervention Type: DRUG

Ribociclib

Starting out dose of ribociclib for cohort A1 Phase 1-Part A: 200mg/m2/day. Starting out dose for Cohort A2 and A3 was 100mg/m2/day.

Intervention Type: DRUG

Other Intervention Names

Hycamtin; Temodar; Kisqali; LEE011

Eligibility Criteria

Inclusion Criteria

1. Participants and/or guardian have the ability to understand and the willingness to sign a written informed consent document.

2. Age ≥ 12 months and ≤ 21 years at the time of signing consent form Note: The first dose level of Phase I - part A (dose finding) will enroll participants ≥ 12 years - 21 years old, and may expand to younger participants (≥ 12 months to < 12 years) as determined by the data.

3. Histologically or cytologically confirmed solid tumors listed below that have progressed despite standard therapy or for which no effective standard therapy exists.

1. Neuroblastoma (for Phase I and Phase II): Histologically proven neuroblastoma as per International Neuroblastoma Staging System (INSS); Relapsed or refractory disease; Measurable disease per International Neuroblastoma Response criteria (INRC); Bone marrow only disease not eligible; Available MYCN status before screening

2. Medulloblastoma (for Phase I) regardless of genetic status (i.e. Groups 3 or 4 WNT-activated or non-WNT, SHH-activated or non-SHH)

3. High-grade glioma (for Phase I): including HGG NOS, WHO Grade III or Grade IV; Glioblastoma, IDH-wildtype or IDH-mutant; Anaplastic astrocytoma, IDH-mutant; Anaplastic oligodendroglioma, IDH-mutant; Anaplastic pleomorphic xanthoastrocytoma; Diffuse midline gliomas, H3 K27-altered; Diffuse hemispheric glioma, H3 G34-mutant; Diffuse pediatric-type HGG, H3-wildtype and IDH-wildtype.

4. Malignant rhabdoid tumor (for Phase I) includes diagnoses of atypical teratoid/rhabdoid tumor (AT/RT), and rhabdoid tumor of the kidney (RTK), and other soft tissues as defined by 2 of the 3 following criteria; either (1)+(2) or (1)+(3): (1) Morphology and immunophenotypic panel consistent with rhabdoid tumor; (2) Loss of SMARCB1 confirmed by immunohistochemistry; (3) Molecular confirmation of tumor-specific bi-allelic SMARCB1 loss/mutation is encouraged in cases where SMARCB1 immunohistochemistry is equivocal, and required if SMARCB1 immunohistochemistry is not available

5. Rhabdomyosarcoma (for Phase I) independent of fusion status and subtype

4. Participants with CNS disease who are on corticosteroids should take stable doses for at least 7 days prior to first dose of ribociclib with no plans for escalation.

5. Performance status:

1. ≤ 16 years: Lansky Play score ≥ 50%

2. >16 years: Karnofsky performance status ≥ 50% or ECOG < 3

6. Life expectancy of ≥ 12 weeks at the time of enrollment

7. Adequate bone marrow function (bone marrow may be involved with tumor) and organ function

8. Adequate hepatic, renal, cardiac function

9. Females who are sexually active must agree to use highly effective contraception during and for 6 months after treatment. Additionally, females of childbearing potential must have a negative serum pregnancy test within 7 days prior to the first dose of study medication. Pregnant or lactating females are not eligible for the study.

10. Sexually active males (including those that have had a vasectomy), who do not agree to abstinence, must be willing to use a condom during intercourse while on study treatment and for 6 months after stopping treatment.

Exclusion Criteria

1. Known hypersensitivity to any of the excipients of ribociclib or topotecan or temozolomide.

2. Not recovered from clinical and laboratory acute toxicities related to prior anti-cancer therapies

3. Concurrent severe and/or uncontrolled concurrent medical conditions (serious infections or significant cardiac, pulmonary, hepatic, psychiatric, GI disease, or other organ dysfunction) that in the investigator's judgement could compromise their ability to tolerate or absorb protocol therapy or would interfere with the study procedures or results

4. Clinically significant, uncontrolled heart disease and/or cardiac repolarization abnormality

5. History of QTc prolongation; taking medications with a known risk to prolong the QT interval hat cannot be discontinued or replaced by safe alternative medication

6. Currently taking medications that are mainly metabolized by CYP3A4/5 with a narrow therapeutic index, strong inducers or inhibitors of CYP3A4/5, herbal preparations/medications and dietary supplements

7. Vaccinated with live, attenuated vaccines within 4 weeks

8. Participated in a prior investigational study within 30 days

9. Received prior treatment with a CDK4/6 inhibitor

10. Received last dose of anticancer therapy (including experimental) within 4 weeks

11. Previous myeloablative therapy with autologous hematopoietic stem cell rescue within 8 weeks

12. Allogeneic stem cell transplant within 3 months

13. Has last fraction of radiation within 4 weeks

14. Major surgery within 2 weeks

15. Pregnant or nursing (breast feeding) female participant or female participant who plans to become pregnant or breast-feed during the trial.

• Minimum Eligible Age: 12 Months
• Maximum Eligible Age: 21 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Innovative Therapies For Children with Cancer Consortium

OTHER

Sponsor Role: collaborator

Novartis Pharmaceuticals

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

Dana Farber Cancer Institute

Boston, Massachusetts, United States

Cohen Children's Medical Center of New York

New Hyde Park, New York, United States

St Jude s Childrens Research Hospital

Memphis, Tennessee, United States

Novartis Investigative Site

Cologne, , Germany

Novartis Investigative Site

Milan, MI, Italy

Novartis Investigative Site

Sutton, Surrey, United Kingdom

Countries

United States; Germany; Italy; United Kingdom

Related Links

https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=18345

Link to study results

https://www.novctrd.com/ctrdweb/patientsummary/patientsummaries?patientSummaryId=2787

A Plain Language Trial Summary is available on www.novctrd.com

Other Identifiers

2024-512095-35-00

Identifier Type: REGISTRY

Identifier Source: secondary_id

CLEE011Q12101

Identifier Type: -

Identifier Source: org_study_id