Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals

NCT ID: NCT05428137

Last Updated: 2024-03-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-01

Study Completion Date

2024-12-31

Brief Summary

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Investigate the effect of a probiotic (live bacteria) and postbiotic (heat-treated bacteria) strains in overweight individuals.

Detailed Description

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This study aims to investigate the safety and efficacy of live and heat treated bacteria on body composition of overweight individuals. The trial will be run in a single research centre and will recruit adult men and women, with BMI of 25-33kg/m2 with abdominal obesity.

Conditions

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Obesity Abdominal Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

3 arm parallel design
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Probiotic

Live bacteria strain in a form of a capsule daily for 16 weeks

Group Type ACTIVE_COMPARATOR

Probiotic

Intervention Type DIETARY_SUPPLEMENT

Live bacteria strain in a form of a capsule daily for 16 weeks

Postbiotic

Heat treated bacteria strain in a form of a capsule daily for 16 weeks

Group Type ACTIVE_COMPARATOR

Postbiotic

Intervention Type DIETARY_SUPPLEMENT

Heat treated bacteria strain in a form of a capsule daily for 16 weeks

Placebo

Placebo in a form of a capsule administered for 16 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Placebo in a form of a capsule given for 16 weeks

Interventions

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Probiotic

Live bacteria strain in a form of a capsule daily for 16 weeks

Intervention Type DIETARY_SUPPLEMENT

Postbiotic

Heat treated bacteria strain in a form of a capsule daily for 16 weeks

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo in a form of a capsule given for 16 weeks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Body mass index 25-33kg/m2
* Abdominal obesity (female waist circumference\>85cm; male waist circumference\>90cm)
* written informed consent

Exclusion Criteria

* Taking the following medication within 1 month before starting the study: appetite stimulants/suppressants, lipid lowering drug, contraceptive
* taking antibiotics within 2 months before starting the study
* secondary obesity or secondary hypertension, diabetes type 1, GI disease, dyslipidaemia, type 2diabetes, hypertension
* consumption of pre- and probiotic-enriched products or dietary supplement for at least 4 weeks prior to the first screening visit
* nicotine, drug or alcohol abuse,
* other condition that, in the opinion of the investigators, would make participation not in the best interest of the patient or could prevent, limit or confound the Study's results
Minimum Eligible Age

19 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Archer-Daniels-Midland Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Daniel Ramon Vidal

Role: STUDY_CHAIR

ADM Biopolis

Locations

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The Catholic University of Korea St. Vincent's Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Vineetha Vijayakumar, PhD

Role: CONTACT

07885966211

Facility Contacts

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MI KYUNG KIM, Dr

Role: primary

Other Identifiers

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PCTB202014

Identifier Type: -

Identifier Source: org_study_id

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